Hotels in St. Charles MO

St. Charles MO hotels

Book with Choice Hotels in St. Charles, MO and enjoy this fun-filled historical city

St. Charles was the last town stop for the Lewis and Clark Expedition before the group headed into the wild. Because of this, the city is now an important historical area with much to offer visitors wishing to learn more about the famous expedition.

Book with one of these St. Charles, MO hotels, and you will have direct access to some of the most popular city attractions, including:

  • St. Charles Historic District
  • Ameristar Casino St. Charles
  • First Missouri State Capitol Historic Site
  • Fast Lane Classic Cars
  • Lewis & Clark Center
  • The Family Arena
14 Hotels Found
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1
Hotel in Saint Charles MO - Comfort Suites

Comfort Suites

1400 S. Fifth Street

Saint Charles, MO, US, 63301

Excellent!
4.5
(262 reviews)
1.1mi1.7km SW
  • Free Breakfast
  • Fitness Center
  • Free Internet
  • Laundry, Guest
  • Pet Friendly
  • Smoke Free
Starting at:
$10400
2
Hotel in Saint Charles MO - Sleep Inn

Sleep Inn

150 Fountain Lakes Blvd.

Saint Charles, MO, US, 63301

Very Good!
3.9
(93 reviews)
3.6mi5.9km NW
  • Free Breakfast
  • Fitness Center
  • Free Internet
  • Laundry, Guest
  • Pet Friendly
Starting at:
$9900
3
Hotel in Saint Charles MO - Rodeway Inn

Rodeway Inn

3800 Harry S. Truman Boulevard

Saint Charles, MO, US, 63301

4.4mi7.1km W
  • Free Internet
  • Laundry, Guest
  • Pet Friendly
Starting at:
$5499
4
Hotel in St. Louis MO - Comfort Inn Westport

Comfort Inn Westport

12031 Lackland Rd.

St. Louis, MO, US, 63146

Very Good!
4.0
(389 reviews)
6.2mi9.9km S
  • Free Airport Shuttle
  • Free Breakfast
  • Fitness Center
  • Free Internet
  • Laundry, Guest
  • Pet Friendly
  • Restaurant
  • Smoke Free
Starting at:
$7999
5
Hotel in Hazelwood MO - Comfort Inn & Suites

Comfort Inn & Suites

7133 Douglas Palmer Place

Hazelwood, MO, US, 63042

Excellent!
4.4
(174 reviews)
6.8mi10.9km E
  • Free Breakfast
  • Fitness Center
  • Free Internet
  • Laundry, Guest
Starting at:
$7900
6
Hotel in Saint Louis MO - Quality Inn Airport

Quality Inn Airport

10232 Natural Bridge Rd.

Saint Louis, MO, US, 63134

Very Good!
3.7
(409 reviews)
7.4mi12.0km SE
  • Free Airport Shuttle
  • Free Breakfast
  • Fitness Center
  • Free Internet
  • Laundry, Guest
  • Meeting Space
  • Pet Friendly
  • Restaurant
Starting at:
$5999
7
Hotel in Saint Louis MO - Econo Lodge

Econo Lodge

4576 Woodson Rd.

Saint Louis, MO, US, 63134

7.5mi12.1km SE
  • Free Breakfast
  • Free Internet
Starting at:
$4699
8
Hotel in Florissant MO - Quality Inn

Quality Inn

55 Dunn Road

Florissant, MO, US, 63031

Very Good!
3.7
(6 reviews)
7.9mi12.6km E
  • Free Breakfast
  • Fitness Center
  • Free Internet
  • Meeting Space
Starting at:
$6999
9
Hotel in O Fallon MO - Comfort Inn & Suites

Comfort Inn & Suites

100 Comfort Inn Court

O Fallon, MO, US, 63366

Good!
3.5
(91 reviews)
10.7mi17.1km W
  • Free Breakfast
  • Fitness Center
  • Free Internet
  • Laundry, Guest
  • Pet Friendly
Starting at:
$8999
10
Hotel in Chesterfield MO - Comfort Inn & Suites

Comfort Inn & Suites

18375 Chesterfield Arpt. Rd.

Chesterfield, MO, US, 63005

Excellent!
4.2
(284 reviews)
11.9mi19.1km SW
  • Free Breakfast
  • Fitness Center
  • Free Internet
  • Laundry, Guest
Starting at:
$8400
11
Hotel in Saint Louis MO - Econo Lodge Southwest

Econo Lodge Southwest

3730 S. Lindbergh Blvd.

Saint Louis, MO, US, 63127-1397

16.5mi26.6km S
  • Free Breakfast
  • Fitness Center
  • Free Internet
  • Laundry, Guest
  • Pet Friendly
Starting at:
$5499
12
Hotel in Granite City IL - Econo Lodge  Inn & Suites

Econo Lodge Inn & Suites

3236 W. Chain of Rocks Road

Granite City, IL, US, 62040

19.5mi31.3km E
  • Free Breakfast
  • Free Internet
  • Pet Friendly
Starting at:
$6000
13
Hotel in Alton IL - Comfort Inn

Comfort Inn

11 Crossroads Ct.

Alton, IL, US, 62002

Excellent!
4.2
(111 reviews)
20.6mi33.1km NE
  • Free Breakfast
  • Laundry, Guest
  • Pet Friendly
Starting at:
$8900
14
Hotel in Cahokia IL - Comfort Inn & Suites

Comfort Inn & Suites

1607 Pontiac Drive

Cahokia, IL, US, 62206

Very Good!
3.9
(186 reviews)
23.2mi37.4km SE
  • Free Breakfast
  • Fitness Center
  • Free Internet
  • Pet Friendly
  • Smoke Free
Starting at:
$7400
$6660