Book Boutique Hotels in La Mesa, CA

Rodeway Inn San Diego Near SDSU
5399 Adobe Falls Road,
San Diego, CA, 92120, US
3.61 mi from La Mesa, CA, USA
3.45 stars rating. Good. 1115 reviews3.45 stars rating. Good. 1115 reviews
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Strikethrough Rate:~~$79~~Discounted rate:$75USD/night
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Rodeway Inn Santee San Diego East
10135 Mission Gorge Road,
Santee, CA, 92071-3813, US
5.57 mi from La Mesa, CA, USA
3.62 stars rating. Good. 525 reviews3.62 stars rating. Good. 525 reviews
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Strikethrough Rate:~~$89~~Discounted rate:$84USD/night
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Rodeway Inn Lemon Grove San Diego East
7458 Broadway,
Lemon Grove, CA, 91945, US
1.91 mi from La Mesa, CA, USA
2.6 stars rating. Fair. 81 reviews2.6 stars rating. Fair. 81 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$102USD/night
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Quality Inn & Suites El Cajon San Diego East
650 N Mollison Ave, Building A,
El Cajon, CA, 92021, US
4.85 mi from La Mesa, CA, USA
2.16 stars rating. Fair. 251 reviews2.16 stars rating. Fair. 251 reviews
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Strikethrough Rate:~~$91~~Discounted rate:$86USD/night
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NEW HOTEL
WoodSpring Suites Santee - San Diego Northeast
8801 Mission Gorge Road,
Santee, CA, 92071, US
4.78 mi from La Mesa, CA, USA
No Reviews YetNo Reviews Yet
$84USD/night
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Clarion Pointe El Cajon San Diego East
855 Sandalwood Dr,
El Cajon, CA, 92021, US
4.84 mi from La Mesa, CA, USA
2.5 stars rating. Fair. 117 reviews2.5 stars rating. Fair. 117 reviews
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Strikethrough Rate:~~$104~~Discounted rate:$99USD/night
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Quality Inn San Diego I-5 Naval Base
3878 Dalbergia Court,
San Diego, CA, 92113, US
7.76 mi from La Mesa, CA, USA
3.81 stars rating. Good. 718 reviews3.81 stars rating. Good. 718 reviews
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Strikethrough Rate:~~$124~~Discounted rate:$100USD/night
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Rodeway Inn El Cajon - San Diego East
1368 East Main Street,
El Cajon, CA, 92021, US
5.7 mi from La Mesa, CA, USA
2.89 stars rating. Fair. 18 reviews2.89 stars rating. Fair. 18 reviews
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Strikethrough Rate:~~$91~~Discounted rate:$78USD/night
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Comfort Inn Chula Vista San Diego South
91 E. Bonita Road,
Chula Vista, CA, 91910, US
8.58 mi from La Mesa, CA, USA
3.86 stars rating. Good. 1843 reviews3.86 stars rating. Good. 1843 reviews
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Strikethrough Rate:~~$164~~Discounted rate:$148USD/night
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Rodeway Inn National City San Diego South
607 Roosevelt Ave,
National City, CA, 91950, US
7.99 mi from La Mesa, CA, USA
3.09 stars rating. Fair. 54 reviews3.09 stars rating. Fair. 54 reviews
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Strikethrough Rate:~~$89~~Discounted rate:$80USD/night
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Comfort Inn San Diego Miramar
9350 Kearny Mesa Road,
San Diego, CA, 92126, US
10.28 mi from La Mesa, CA, USA
3.36 stars rating. Good. 1001 reviews3.36 stars rating. Good. 1001 reviews
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Strikethrough Rate:~~$104~~Discounted rate:$99USD/night
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Quality Inn San Diego South - Chula Vista
778 Broadway,
Chula Vista, CA, 91910-5329, US
10.77 mi from La Mesa, CA, USA
3.96 stars rating. Good. 84 reviews3.96 stars rating. Good. 84 reviews
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Strikethrough Rate:~~$189~~Discounted rate:$170USD/night
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Carlton Oaks Lodge, an Ascend Collection Hotel
9200 Inwood Drive,
Santee, CA, 92071, US
5.27 mi from La Mesa, CA, USA
3.25 stars rating. Good. 401 reviews3.25 stars rating. Good. 401 reviews
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Strikethrough Rate:~~$169~~Discounted rate:$146USD/night
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Comfort Inn Gaslamp Convention Center
660 G Street,
San Diego, CA, 92101, US
8.75 mi from La Mesa, CA, USA
3.91 stars rating. Good. 2271 reviews3.91 stars rating. Good. 2271 reviews
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Strikethrough Rate:~~$164~~Discounted rate:$156USD/night
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Comfort Inn San Diego Airport At the Harbor
5102 N. Harbor Drive,
San Diego, CA, 92106, US
12.23 mi from La Mesa, CA, USA
3.93 stars rating. Good. 2112 reviews3.93 stars rating. Good. 2112 reviews
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Strikethrough Rate:~~$155~~Discounted rate:$147USD/night
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Quality Suites San Diego Otay Mesa
2351 Otay Center Drive,
San Diego, CA, 92154-7614, US
15.35 mi from La Mesa, CA, USA
3.46 stars rating. Good. 497 reviews3.46 stars rating. Good. 497 reviews
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Strikethrough Rate:~~$99~~Discounted rate:$94USD/night
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Comfort Inn San Diego Old Town
2380 Moore Street,
San Diego, CA, 92110, US
10.04 mi from La Mesa, CA, USA
3.62 stars rating. Good. 680 reviews3.62 stars rating. Good. 680 reviews
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Strikethrough Rate:~~$180~~Discounted rate:$162USD/night
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Country Inn & Suites by Radisson, San Diego North, CA
5975 Lusk Boulevard,
San Diego, CA, 92121, US
13.35 mi from La Mesa, CA, USA
4.28 stars rating. Excellent. 383 reviews4.28 stars rating. Excellent. 383 reviews
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Strikethrough Rate:~~$159~~Discounted rate:$143USD/night
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AWARD WINNER
Rodeway Inn Encinitas North
1444 N. Coast Hwy 101,
Encinitas, CA, 92024, US
26.7 mi from La Mesa, CA, USA
3.86 stars rating. Good. 895 reviews3.86 stars rating. Good. 895 reviews
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Strikethrough Rate:~~$90~~Discounted rate:$86USD/night
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Econo Lodge Inn & Suites Escondido Downtown
515 W Washington Avenue,
Escondido, CA, 92025, US
24.91 mi from La Mesa, CA, USA
3.62 stars rating. Good. 615 reviews3.62 stars rating. Good. 615 reviews
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Strikethrough Rate:~~$79~~Discounted rate:$75USD/night
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Comfort Inn Encinitas Near Legoland
607 Leucadia Blvd,
Encinitas, CA, 92024, US
25.75 mi from La Mesa, CA, USA
3.2 stars rating. Good. 1223 reviews3.2 stars rating. Good. 1223 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$110USD/night
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Comfort Inn Escondido San Diego North County
1290 West Valley Parkway,
Escondido, CA, 92029, US
24.4 mi from La Mesa, CA, USA
4.05 stars rating. Very Good. 1486 reviews4.05 stars rating. Very Good. 1486 reviews
$136USD/night
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Quality Inn Escondido San Diego North County
501 W Mission Ave,
Escondido, CA, 92025, US
25.17 mi from La Mesa, CA, USA
3.35 stars rating. Good. 284 reviews3.35 stars rating. Good. 284 reviews
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Strikethrough Rate:~~$109~~Discounted rate:$104USD/night
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Rodeway Inn Escondido Downtown
250 W. El Norte Pkwy,
Escondido, CA, 92026, US
26.01 mi from La Mesa, CA, USA
3.21 stars rating. Good. 256 reviews3.21 stars rating. Good. 256 reviews
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Strikethrough Rate:~~$97~~Discounted rate:$92USD/night
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Sleep Inn Tijuana
Blvd. M. Clouthier No. 16651, Rio Tijuana,
Tijuana, BCN, 22226, MX
19.72 mi from La Mesa, CA, USA
3.82 stars rating. Good. 633 reviews3.82 stars rating. Good. 633 reviews
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Strikethrough Rate:~~$1,495~~Discounted rate:$1,346MXN/night
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Comfort Inn Sea World Area
3880 Greenwood St.,
San Diego, CA, 92110, US
10.65 mi from La Mesa, CA, USA
4.01 stars rating. Very Good. 534 reviews4.01 stars rating. Very Good. 534 reviews
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NEW TO CHOICE
Comfort Suites Tijuana
Av. C Niños Héroes 1584, Zona Centro,
Tijuana, BCN, 22000, MX
16.55 mi from La Mesa, CA, USA
No Reviews YetNo Reviews Yet
Coming soonStart booking Feb 24, 2026
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Good to know

Boutique hotels

27 hotels in La Mesa

Highest Price

$1,346

Lowest Price

$75

Avg. rating

25 Boutique hotels near La Mesa, CA, USA

Rodeway Inn San Diego Near SDSU

Rodeway Inn Santee San Diego East

Rodeway Inn Lemon Grove San Diego East

Quality Inn & Suites El Cajon San Diego East

WoodSpring Suites Santee - San Diego Northeast

Clarion Pointe El Cajon San Diego East

Quality Inn San Diego I-5 Naval Base

Rodeway Inn El Cajon - San Diego East

Comfort Inn Chula Vista San Diego South

Rodeway Inn National City San Diego South

Comfort Inn San Diego Miramar

Quality Inn San Diego South - Chula Vista

Carlton Oaks Lodge, an Ascend Collection Hotel

Comfort Inn Gaslamp Convention Center

Comfort Inn San Diego Airport At the Harbor

Quality Suites San Diego Otay Mesa

Comfort Inn San Diego Old Town

Country Inn & Suites by Radisson, San Diego North, CA

Rodeway Inn Encinitas North

Econo Lodge Inn & Suites Escondido Downtown

Comfort Inn Encinitas Near Legoland

Comfort Inn Escondido San Diego North County

Quality Inn Escondido San Diego North County

Rodeway Inn Escondido Downtown

Sleep Inn Tijuana

Change your dates to book properties below.

Comfort Inn Sea World Area

Comfort Suites Tijuana

Other La Mesa searches

Good to know

27 hotels in La Mesa

$1,346

$75

3.2 (18077 reviews)