Book Comfort Suites Hotels in La Mesa, CA

Comfort Inn Chula Vista San Diego South
91 E. Bonita Road,
Chula Vista, CA, 91910, US
13.81 km from La Mesa, CA, USA
3.86 stars rating. Good. 1850 reviews3.86 stars rating. Good. 1850 reviews
Book Now & Save 10%
Strikethrough Rate:~~$129~~Discounted rate:$116USD/night
Member Rate
See Availability
Comfort Inn San Diego Airport At the Harbor
5102 N. Harbor Drive,
San Diego, CA, 92106, US
19.68 km from La Mesa, CA, USA
3.93 stars rating. Good. 2123 reviews3.93 stars rating. Good. 2123 reviews
Book Now & Save 7%
Strikethrough Rate:~~$133~~Discounted rate:$124USD/night
Member Rate
See Availability
Comfort Inn San Diego Miramar
9350 Kearny Mesa Road,
San Diego, CA, 92126, US
16.55 km from La Mesa, CA, USA
3.37 stars rating. Good. 1004 reviews3.37 stars rating. Good. 1004 reviews
Book Now & Save 7%
Strikethrough Rate:~~$92~~Discounted rate:$86USD/night
Member Rate
See Availability
Comfort Inn Sea World Area
3880 Greenwood St.,
San Diego, CA, 92110, US
17.14 km from La Mesa, CA, USA
4.01 stars rating. Very Good. 540 reviews4.01 stars rating. Very Good. 540 reviews
Book Now & Save 7%
Strikethrough Rate:~~$110~~Discounted rate:$102USD/night
Member Rate
See Availability
Comfort Inn San Diego Old Town
2380 Moore Street,
San Diego, CA, 92110, US
16.17 km from La Mesa, CA, USA
3.62 stars rating. Good. 680 reviews3.62 stars rating. Good. 680 reviews
Book Now & Save 10%
Strikethrough Rate:~~$154~~Discounted rate:$139USD/night
Member Rate
See Availability
Comfort Inn Escondido San Diego North County
1290 West Valley Parkway,
Escondido, CA, 92029, US
39.28 km from La Mesa, CA, USA
4.05 stars rating. Very Good. 1486 reviews4.05 stars rating. Very Good. 1486 reviews
$136USD/night
See Availability
Comfort Inn Encinitas Near Legoland
607 Leucadia Blvd,
Encinitas, CA, 92024, US
41.44 km from La Mesa, CA, USA
3.2 stars rating. Good. 1225 reviews3.2 stars rating. Good. 1225 reviews
Book Now & Save 16%
Strikethrough Rate:~~$99~~Discounted rate:$83USD/night
Member Rate
See Availability

Below are additional hotels in the area that do not match your exact search criteria.

Rodeway Inn San Diego Near SDSU
5399 Adobe Falls Road,
San Diego, CA, 92120, US
5.81 km from La Mesa, CA, USA
3.45 stars rating. Good. 1115 reviews3.45 stars rating. Good. 1115 reviews
Book Now & Save 7%
Strikethrough Rate:~~$94~~Discounted rate:$87USD/night
Member Rate
See Availability
Rodeway Inn Lemon Grove San Diego East
7458 Broadway,
Lemon Grove, CA, 91945, US
3.08 km from La Mesa, CA, USA
2.6 stars rating. Fair. 81 reviews2.6 stars rating. Fair. 81 reviews
Book Now & Save 16%
Strikethrough Rate:~~$89~~Discounted rate:$74USD/night
Member Rate
See Availability
Quality Inn San Diego I-5 Naval Base
3878 Dalbergia Court,
San Diego, CA, 92113, US
12.49 km from La Mesa, CA, USA
3.81 stars rating. Good. 718 reviews3.81 stars rating. Good. 718 reviews
Book Now & Save 19%
Strikethrough Rate:~~$114~~Discounted rate:$92USD/night
Member Rate
See Availability
Rodeway Inn Santee San Diego East
10135 Mission Gorge Road,
Santee, CA, 92071-3813, US
8.97 km from La Mesa, CA, USA
3.63 stars rating. Good. 528 reviews3.63 stars rating. Good. 528 reviews
Book Now & Save 10%
Strikethrough Rate:~~$89~~Discounted rate:$80USD/night
Member Rate
Fees included
See Availability
Clarion Pointe El Cajon San Diego East
855 Sandalwood Dr,
El Cajon, CA, 92021, US
7.79 km from La Mesa, CA, USA
2.5 stars rating. Fair. 117 reviews2.5 stars rating. Fair. 117 reviews
Book Now & Save 5%
Strikethrough Rate:~~$90~~Discounted rate:$86USD/night
Member Rate
See Availability
Carlton Oaks Lodge, an Ascend Collection Hotel
9200 Inwood Drive,
Santee, CA, 92071, US
8.49 km from La Mesa, CA, USA
3.25 stars rating. Good. 403 reviews3.25 stars rating. Good. 403 reviews
Book Now & Save 14%
Strikethrough Rate:~~$154~~Discounted rate:$133USD/night
Special Rate
Fees included
See Availability
Quality Inn San Diego South - Chula Vista
778 Broadway,
Chula Vista, CA, 91910-5329, US
17.33 km from La Mesa, CA, USA
3.94 stars rating. Good. 86 reviews3.94 stars rating. Good. 86 reviews
Book Now & Save 10%
Strikethrough Rate:~~$84~~Discounted rate:$76USD/night
Member Rate
See Availability
Quality Inn & Suites El Cajon San Diego East
650 N Mollison Ave, Building A,
El Cajon, CA, 92021, US
7.81 km from La Mesa, CA, USA
2.16 stars rating. Fair. 251 reviews2.16 stars rating. Fair. 251 reviews
Book Now & Save 7%
Strikethrough Rate:~~$92~~Discounted rate:$86USD/night
Member Rate
See Availability
Rodeway Inn El Cajon - San Diego East
1368 East Main Street,
El Cajon, CA, 92021, US
9.18 km from La Mesa, CA, USA
3 stars rating. Fair. 19 reviews3 stars rating. Fair. 19 reviews
Book Now & Save 16%
Strikethrough Rate:~~$78~~Discounted rate:$65USD/night
Member Rate
See Availability
Rodeway Inn National City San Diego South
607 Roosevelt Ave,
National City, CA, 91950, US
12.86 km from La Mesa, CA, USA
3.15 stars rating. Good. 60 reviews3.15 stars rating. Good. 60 reviews
Book Now & Save 19%
Strikethrough Rate:~~$79~~Discounted rate:$64USD/night
Member Rate
See Availability
Country Inn & Suites by Radisson, San Diego North, CA
5975 Lusk Boulevard,
San Diego, CA, 92121, US
21.48 km from La Mesa, CA, USA
4.28 stars rating. Excellent. 383 reviews4.28 stars rating. Excellent. 383 reviews
Book Now & Save 10%
Strikethrough Rate:~~$221~~Discounted rate:$199USD/night
Member Rate
See Availability
Quality Suites San Diego Otay Mesa
2351 Otay Center Drive,
San Diego, CA, 92154-7614, US
24.71 km from La Mesa, CA, USA
3.47 stars rating. Good. 505 reviews3.47 stars rating. Good. 505 reviews
Book Now & Save 7%
Strikethrough Rate:~~$99~~Discounted rate:$92USD/night
Member Rate
See Availability
AWARD WINNER
Rodeway Inn Encinitas North
1444 N. Coast Hwy 101,
Encinitas, CA, 92024, US
42.97 km from La Mesa, CA, USA
3.86 stars rating. Good. 900 reviews3.86 stars rating. Good. 900 reviews
Book Now & Save 5%
Strikethrough Rate:~~$70~~Discounted rate:$67USD/night
Member Rate
Fees included
See Availability
Quality Inn Escondido San Diego North County
501 W Mission Ave,
Escondido, CA, 92025, US
40.51 km from La Mesa, CA, USA
3.35 stars rating. Good. 284 reviews3.35 stars rating. Good. 284 reviews
Book Now & Save 7%
Strikethrough Rate:~~$90~~Discounted rate:$84USD/night
Member Rate
See Availability
Econo Lodge Inn & Suites Escondido Downtown
515 W Washington Avenue,
Escondido, CA, 92025, US
40.09 km from La Mesa, CA, USA
3.62 stars rating. Good. 617 reviews3.62 stars rating. Good. 617 reviews
Book Now & Save 7%
Strikethrough Rate:~~$74~~Discounted rate:$69USD/night
Member Rate
See Availability
Rodeway Inn Escondido Downtown
250 W. El Norte Pkwy,
Escondido, CA, 92026, US
41.86 km from La Mesa, CA, USA
3.21 stars rating. Good. 256 reviews3.21 stars rating. Good. 256 reviews
Book Now & Save 7%
Strikethrough Rate:~~$79~~Discounted rate:$73USD/night
Member Rate
See Availability
Sleep Inn Tijuana
Blvd. M. Clouthier No. 16651, Rio Tijuana,
Tijuana, BCN, 22226, MX
31.74 km from La Mesa, CA, USA
3.82 stars rating. Good. 637 reviews3.82 stars rating. Good. 637 reviews
Book Now & Save 10%
Strikethrough Rate:~~$1,845~~Discounted rate:$1,661MXN/night
Member Rate
See Availability

Change your dates to book properties below.

Comfort Inn Gaslamp Convention Center
660 G Street,
San Diego, CA, 92101, US
14.08 km from La Mesa, CA, USA
3.91 stars rating. Good. 2272 reviews3.91 stars rating. Good. 2272 reviews
Sold outfor your selected dates
See Availability
NEW TO CHOICE
Comfort Suites Tijuana
Av. C Niños Héroes 1584, Zona Centro,
Tijuana, BCN, 22000, MX
26.64 km from La Mesa, CA, USA
No Reviews YetNo Reviews Yet
Coming soonStart booking Feb 24, 2026
See Availability

Good to know

Number of hotels

7 of 26 hotels in La Mesa

Highest Price

$1,661

Lowest Price

$64

Avg. rating

7 hotels near La Mesa, CA, USA match your filters

Comfort Inn Chula Vista San Diego South

Comfort Inn San Diego Airport At the Harbor

Comfort Inn San Diego Miramar

Comfort Inn Sea World Area

Comfort Inn San Diego Old Town

Comfort Inn Escondido San Diego North County

Comfort Inn Encinitas Near Legoland

Below are additional hotels in the area that do not match your exact search criteria.

Rodeway Inn San Diego Near SDSU

Rodeway Inn Lemon Grove San Diego East

Quality Inn San Diego I-5 Naval Base

Rodeway Inn Santee San Diego East

Clarion Pointe El Cajon San Diego East

Carlton Oaks Lodge, an Ascend Collection Hotel

Quality Inn San Diego South - Chula Vista

Quality Inn & Suites El Cajon San Diego East

Rodeway Inn El Cajon - San Diego East

Rodeway Inn National City San Diego South

Country Inn & Suites by Radisson, San Diego North, CA

Quality Suites San Diego Otay Mesa

Rodeway Inn Encinitas North

Quality Inn Escondido San Diego North County

Econo Lodge Inn & Suites Escondido Downtown

Rodeway Inn Escondido Downtown

Sleep Inn Tijuana

Change your dates to book properties below.

Comfort Inn Gaslamp Convention Center

Comfort Suites Tijuana

Other La Mesa searches

Good to know

7 of 26 hotels in La Mesa

$1,661

$64

3.3 (18140 reviews)