Hotels in Knox City, MO – Choice Hotels

Below are additional hotels in the area that do not match your exact search criteria.

Quality Inn Kirksville
2209 N. Baltimore Street,
Kirksville, MO, 63501, US
49.42 km from Knox City, MO, US
3.76 stars rating. Good. 674 reviews
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Strikethrough Rate:~~$65~~Discounted rate:$56USD/night
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AWARD WINNER
Quality Inn & Suites Keokuk North
3404 Main Street,
Keokuk, IA, 52632, US
59.52 km from Knox City, MO, US
4.27 stars rating. Excellent. 770 reviews
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Strikethrough Rate:~~$117~~Discounted rate:$105USD/night
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AWARD WINNER
Quality Inn & Suites Quincy - Downtown
225 S 4th Street,
Quincy, IL, 62301, US
56.22 km from Knox City, MO, US
4.31 stars rating. Excellent. 373 reviews
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Strikethrough Rate:~~$125~~Discounted rate:$113USD/night
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AWARD WINNER
Comfort Inn & Suites Macon
1821 N. Missouri St,
Macon, MO, 63552-1973, US
58.02 km from Knox City, MO, US
4.63 stars rating. Exceptional. 1733 reviews
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Strikethrough Rate:~~$162~~Discounted rate:$154USD/night
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Quality Inn & Suites Hannibal West
120 Lindsey Drive, Hwy 36,
Hannibal, MO, 63401, US
68.46 km from Knox City, MO, US
3.96 stars rating. Good. 2604 reviews
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Strikethrough Rate:~~$95~~Discounted rate:$86USD/night
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Quality Inn & Suites Fort Madison near Hwy 61
6169 Reve Court,
Fort Madison, IA, 52627, US
74.73 km from Knox City, MO, US
4.25 stars rating. Excellent. 936 reviews
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Strikethrough Rate:~~$117~~Discounted rate:$106USD/night
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AWARD WINNER
Sleep Inn & Suites Hannibal West
105 Lakeside Drive,
Hannibal, MO, 63401, US
68.44 km from Knox City, MO, US
4.78 stars rating. Exceptional. 1809 reviews
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Strikethrough Rate:~~$149~~Discounted rate:$134USD/night
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Comfort Inn & Suites Moberly
1801 W Outer Road,
Moberly, MO, 65270, US
85.78 km from Knox City, MO, US
4.21 stars rating. Excellent. 1056 reviews
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Strikethrough Rate:~~$144~~Discounted rate:$128USD/night
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Comfort Inn & Suites - Hannibal
4000 Market Street,
Hannibal, MO, 63401, US
72.5 km from Knox City, MO, US
3.6 stars rating. Good. 1153 reviews
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Strikethrough Rate:~~$99~~Discounted rate:$80USD/night
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NEW TO CHOICE
Econo Lodge Quincy
224 North 36th Street,
Quincy, IL, 62301, US
60.09 km from Knox City, MO, US
1 star rating. Fair. 1 review
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Strikethrough Rate:~~$70~~Discounted rate:$63USD/night
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NEW TO CHOICE
Quality Inn Fairfield
3001 W. Burlington Ave.,
Fairfield, IA, 52556, US
95.96 km from Knox City, MO, US
No Reviews Yet
Coming soonStart booking Mar 17, 2026
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Good to know

Number of hotels

11 hotels in Knox City

Highest Price

$154

Lowest Price

$56

Avg. rating

10 hotels near Knox City, MO, US

Below are additional hotels in the area that do not match your exact search criteria.

Quality Inn Kirksville

Quality Inn & Suites Keokuk North

Quality Inn & Suites Quincy - Downtown

Comfort Inn & Suites Macon

Quality Inn & Suites Hannibal West

Quality Inn & Suites Fort Madison near Hwy 61

Sleep Inn & Suites Hannibal West

Comfort Inn & Suites Moberly

Comfort Inn & Suites - Hannibal

Econo Lodge Quincy

Change your dates to book properties below.

Quality Inn Fairfield

Other Knox City searches

Good to know

11 hotels in Knox City

$154

$56

3.5 (11109 reviews)