Book Mainstay Hotels in Odessa, TX - Choice Hotels

MainStay Suites Odessa I-20
1801 S. Highway 385,
Odessa, TX, 79766, US
2.49 km from Odessa, TX, USA
4.43 stars rating. Excellent. 213 reviews4.43 stars rating. Excellent. 213 reviews
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Strikethrough Rate:~~$109~~Discounted rate:$106USD/night
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MainStay Suites Midland
2500 South Lamesa Road,
Midland, TX, 79701, US
32.66 km from Odessa, TX, USA
3.71 stars rating. Good. 188 reviews3.71 stars rating. Good. 188 reviews
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Strikethrough Rate:~~$109~~Discounted rate:$101USD/night
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Below are additional hotels in the area that do not match your exact search criteria.

Comfort Inn & Suites, Odessa I-20
801 South JBS Parkway,
Odessa, TX, 79761, US
4.9 km from Odessa, TX, USA
3.79 stars rating. Good. 661 reviews3.79 stars rating. Good. 661 reviews
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Strikethrough Rate:~~$112~~Discounted rate:$101USD/night
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Comfort Suites Odessa near University
4801 East 50th Street,
Odessa, TX, 79762, US
6.7 km from Odessa, TX, USA
3.88 stars rating. Good. 676 reviews3.88 stars rating. Good. 676 reviews
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Strikethrough Rate:~~$135~~Discounted rate:$115USD/night
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Sleep Inn & Suites Odessa near University
3101 East Business 20,
Odessa, TX, 79761, US
5.6 km from Odessa, TX, USA
3.96 stars rating. Good. 364 reviews3.96 stars rating. Good. 364 reviews
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Strikethrough Rate:~~$115~~Discounted rate:$104USD/night
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Quality Inn Midland South
902 Interstate 20 West,
Midland, TX, 79701, US
30.91 km from Odessa, TX, USA
3.89 stars rating. Good. 598 reviews3.89 stars rating. Good. 598 reviews
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Strikethrough Rate:~~$65~~Discounted rate:$60USD/night
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AWARD WINNER
Suburban Studios Midland I-20
3001 Antelope Trail,
Midland, TX, 79706, US
24.17 km from Odessa, TX, USA
4.42 stars rating. Excellent. 192 reviews4.42 stars rating. Excellent. 192 reviews
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Strikethrough Rate:~~$122~~Discounted rate:$116USD/night
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Comfort Suites Midland West
5606 Westridge Blvd,
Midland, TX, 79706, US
25.96 km from Odessa, TX, USA
4.25 stars rating. Excellent. 397 reviews4.25 stars rating. Excellent. 397 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$116USD/night
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Comfort Inn Midland South I-20
910 West I-20,
Midland, TX, 79701, US
30.74 km from Odessa, TX, USA
3.69 stars rating. Good. 594 reviews3.69 stars rating. Good. 594 reviews
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Strikethrough Rate:~~$109~~Discounted rate:$98USD/night
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AWARD WINNER
Sleep Inn & Suites Midland West
5612 Deauville Blvd,
Midland, TX, 79706, US
25.72 km from Odessa, TX, USA
4.41 stars rating. Excellent. 703 reviews4.41 stars rating. Excellent. 703 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$116USD/night
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Quality Suites Midland North Loop 250
4706 North Garfield Street,
Midland, TX, 79705, US
32.34 km from Odessa, TX, USA
4 stars rating. Very Good. 642 reviews4 stars rating. Very Good. 642 reviews
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Strikethrough Rate:~~$109~~Discounted rate:$98USD/night
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Rodeway Inn Midland South
1000 S Midkiff Rd,
Midland, TX, 79701-7132, US
28.27 km from Odessa, TX, USA
1.35 stars rating. Fair. 17 reviews1.35 stars rating. Fair. 17 reviews
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Strikethrough Rate:~~$65~~Discounted rate:$57USD/night
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NEW TO CHOICE
Quality Inn
3071 E Business 20,
Odessa, TX, 79761, US
5.42 km from Odessa, TX, USA
No Reviews YetNo Reviews Yet
Coming soonStart booking 02 Feb 2026
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Good to know

Number of hotels

2 of 13 hotels in Odessa

Highest Price

$116

Lowest Price

$57

Avg. rating

3.5 (5245 reviews)