Hotels near U.S. Route 66, Misuri in MO – Choice Hotels

Sleep Inn South Joplin
4100 Missouri 43,
Joplin, MO, 64804, US
5.4 mi from U.S. Rte 66, Joplin, MO, USA
4.33 stars rating. Excellent. 986 reviews4.33 stars rating. Excellent. 986 reviews
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Strikethrough Rate:~~$114~~Discounted rate:$102USD/night
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AWARD WINNER
Quality Inn Joplin I-44
3325 Arizona Avenue,
Joplin, MO, 64804, US
4.24 mi from U.S. Rte 66, Joplin, MO, USA
4.05 stars rating. Very Good. 1170 reviews4.05 stars rating. Very Good. 1170 reviews
$105USD/night
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Econo Lodge Inn & Suites Joplin
3510 South Range Line Rd,
Joplin, MO, 64804, US
4.41 mi from U.S. Rte 66, Joplin, MO, USA
3.23 stars rating. Good. 1027 reviews3.23 stars rating. Good. 1027 reviews
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Strikethrough Rate:~~$84~~Discounted rate:$76USD/night
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AWARD WINNER
Sleep Inn & Suites Webb City
221 S East Street,
Webb City, MO, 64870, US
6.37 mi from U.S. Rte 66, Joplin, MO, USA
4.74 stars rating. Exceptional. 648 reviews4.74 stars rating. Exceptional. 648 reviews
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Strikethrough Rate:~~$159~~Discounted rate:$143USD/night
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Quality Inn & Suites Carthage near Precious Moments Chapel
2701 Hazel St.,
Carthage, MO, 64836, US
13.08 mi from U.S. Rte 66, Joplin, MO, USA
3.31 stars rating. Good. 1098 reviews3.31 stars rating. Good. 1098 reviews
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Strikethrough Rate:~~$94~~Discounted rate:$79USD/night
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Comfort Inn & Suites Pittsburg KS
4009 Parkview Dr.,
Pittsburg, KS, 66762-2305, US
26.23 mi from U.S. Rte 66, Joplin, MO, USA
4.13 stars rating. Very Good. 1226 reviews4.13 stars rating. Very Good. 1226 reviews
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Strikethrough Rate:~~$149~~Discounted rate:$134USD/night
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Quality Inn Neosho
3085 Gardner-Edgewood Dr,
Neosho, MO, 64850, US
19.09 mi from U.S. Rte 66, Joplin, MO, USA
No Reviews YetNo Reviews Yet
Coming soonStart booking 01 feb 2026
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Number of hotels

7 hotels in Joplin

Highest Price

$143

Lowest Price

$76

Avg. rating

3.4 (6155 reviews)