Hotels in Depew, NY – Choice Hotels

Comfort Inn & Suites Buffalo Airport
4345 Genesee Street,
Buffalo, NY, 14225, US
4.16 km from Depew, NY, US
3.99 stars rating. Good. 576 reviews
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Strikethrough Rate:~~$178~~Discounted rate:$160USD/night
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Sleep Inn & Suites Buffalo Airport
100 Holtz Dr.,
Cheektowaga, NY, 14225, US
4.25 km from Depew, NY, US
4.2 stars rating. Excellent. 2638 reviews
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Strikethrough Rate:~~$149~~Discounted rate:$142USD/night
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Comfort Inn University
1 Flint Road,
Amherst, NY, 14226, US
12.61 km from Depew, NY, US
3.88 stars rating. Good. 1810 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$110USD/night
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Quality Inn Near Walden Galleria Mall
475 DINGENS ST,
Cheektowaga, NY, 14206, US
9.14 km from Depew, NY, US
4.13 stars rating. Very Good. 1344 reviews
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Strikethrough Rate:~~$159~~Discounted rate:$143USD/night
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Sleep Inn Amherst - Buffalo North near University
75 Inn Keepers Lane,
Amherst, NY, 14228, US
15.37 km from Depew, NY, US
4.37 stars rating. Excellent. 1736 reviews
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Strikethrough Rate:~~$136~~Discounted rate:$122USD/night
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Comfort Inn & Suites Hamburg - Buffalo South
3615 Commerce Place,
Hamburg, NY, 14075-3638, US
22.29 km from Depew, NY, US
3.48 stars rating. Good. 1379 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$110USD/night
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Econo Lodge Buffalo South
4344 Milestrip Rd.,
Buffalo, NY, 14219, US
16.29 km from Depew, NY, US
3.66 stars rating. Good. 1028 reviews
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Strikethrough Rate:~~$99~~Discounted rate:$95USD/night
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Cambria Hotel Niagara Falls
311 Rainbow Blvd,
Niagara Falls, NY, 14303, US
35.89 km from Depew, NY, US
4.3 stars rating. Excellent. 687 reviews
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Strikethrough Rate:~~$116~~Discounted rate:$111USD/night
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Curtiss Hotel, an Ascend Collection Hotel
210 Franklin Street,
Buffalo, NY, 14202, US
15.03 km from Depew, NY, US
4.32 stars rating. Excellent. 1533 reviews
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Strikethrough Rate:~~$399~~Discounted rate:$379USD/night
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Comfort Inn & Suites Niagara Falls Blvd USA
6115 Niagara Falls Blvd,
Niagara Falls, NY, 14304, US
32.11 km from Depew, NY, US
4.36 stars rating. Excellent. 1409 reviews
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Strikethrough Rate:~~$110~~Discounted rate:$107USD/night
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Quality Inn Lockport - Niagara Falls Area
551 South Transit Street,
Lockport, NY, 14094, US
27.59 km from Depew, NY, US
3.61 stars rating. Good. 665 reviews
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Strikethrough Rate:~~$100~~Discounted rate:$95USD/night
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Econo Lodge Darien Lakes
8493 Alleghany Road,
Corfu, NY, 14036, US
25.72 km from Depew, NY, US
3.71 stars rating. Good. 795 reviews
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Strikethrough Rate:~~$85~~Discounted rate:$82USD/night
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Comfort Inn The Pointe
1 Prospect Pointe,
Niagara Falls, NY, 14303, US
36.35 km from Depew, NY, US
4.31 stars rating. Excellent. 4259 reviews
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Strikethrough Rate:~~$111~~Discounted rate:$107USD/night
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Econo Lodge at the Falls North
5919 Niagara Falls Blvd.,
Niagara Falls, NY, 14304, US
32.31 km from Depew, NY, US
3.77 stars rating. Good. 1634 reviews
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Strikethrough Rate:~~$76~~Discounted rate:$68USD/night
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Quality Inn - Niagara Falls Blvd
7708 Niagara Falls Blvd.,
Niagara Falls, NY, 14304, US
30.92 km from Depew, NY, US
2.81 stars rating. Fair. 1862 reviews
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Strikethrough Rate:~~$91~~Discounted rate:$87USD/night
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Quality Inn & Suites Palm Island Indoor Waterpark
8250 Park Road,
Batavia, NY, 14020, US
42.08 km from Depew, NY, US
2.53 stars rating. Fair. 2279 reviews
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Strikethrough Rate:~~$77~~Discounted rate:$73USD/night
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The Giacomo, an Ascend Collection Hotel
222 1st Street,
Niagara Falls, NY, 14303, US
36.22 km from Depew, NY, US
4.36 stars rating. Excellent. 2169 reviews
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Strikethrough Rate:~~$441~~Discounted rate:$397USD/night
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Comfort Inn & Suites Medina NY near Erie Canal
11591 Maple Ridge Road,
Medina, NY, 14103, US
42.58 km from Depew, NY, US
3.94 stars rating. Good. 168 reviews
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Strikethrough Rate:~~$260~~Discounted rate:$252USD/night
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Quality Hotel & Suites At The Falls
240 First Street,
Niagara Falls, NY, 14303, US
36.25 km from Depew, NY, US
3.15 stars rating. Good. 3392 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$114USD/night
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Comfort Inn
1 Hospitality Drive,
Fort Erie, ON, L2A 6G1, CA
19.41 km from Depew, NY, US
4.16 stars rating. Very Good. 1157 reviews
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Strikethrough Rate:~~$147~~Discounted rate:$140CAD/night
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Comfort Inn Lundy's Lane
7514 Lundys Lane, Building A,
Niagara Falls, ON, L2H 1G8, CA
40.58 km from Depew, NY, US
3.65 stars rating. Good. 1841 reviews
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Strikethrough Rate:~~$99~~Discounted rate:$95CAD/night
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Comfort Hotel
5700 Stanley Avenue,
Niagara Falls, ON, L2G 3X5, CA
38.2 km from Depew, NY, US
3.41 stars rating. Good. 936 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$105CAD/night
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Econo Lodge By the Falls
5781 Victoria Ave.,
Niagara Falls, ON, L2G 3L6, CA
37.72 km from Depew, NY, US
3.34 stars rating. Good. 955 reviews
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Strikethrough Rate:~~$120~~Discounted rate:$114CAD/night
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Country Inn & Suites by Radisson, Niagara Falls, ON
5525 Victoria Avenue,
Niagara Falls, ON, L2G 3L3, CA
37.58 km from Depew, NY, US
4.32 stars rating. Excellent. 1402 reviews
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Strikethrough Rate:~~$224~~Discounted rate:$222CAD/night
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Comfort Inn Fallsview
6645 Fallsview Blvd,
Niagara Falls, ON, L2G 7G1, CA
37.42 km from Depew, NY, US
3.63 stars rating. Good. 5298 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$123CAD/night
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Quality Hotel Fallsview Cascade
5305 Murray Street,
Niagara Falls, ON, L2G 2J3, CA
37.48 km from Depew, NY, US
3.91 stars rating. Good. 3073 reviews
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Strikethrough Rate:~~$180~~Discounted rate:$168CAD/night
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Quality Inn & Suites
5234 Ferry Street,
Niagara Falls, ON, L2G 1R5, CA
37.78 km from Depew, NY, US
2.93 stars rating. Fair. 1730 reviews
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Strikethrough Rate:~~$125~~Discounted rate:$116CAD/night
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Suburban Studios Buffalo Airport
4217 Genesee Street, Building B,
Buffalo, NY, 14225, US
4.3 km from Depew, NY, US
2.27 stars rating. Fair. 33 reviews
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NEW TO CHOICE
CenterWay Hotel Tonawanda
225 Crestmount Ave,
Tonawanda, NY, 14150, US
17.57 km from Depew, NY, US
No Reviews Yet
Coming soonStart booking 01 Apr 2026
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Country Inn & Suites by Radisson, Buffalo South I-90, NY
164B Slade Avenue,
West Seneca, NY, 14224, US
11.24 km from Depew, NY, US
3.61 stars rating. Good. 317 reviews
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Quality Inn Buffalo Airport
4217 Genesee St., Building A,
Buffalo, NY, 14225, US
4.32 km from Depew, NY, US
3.21 stars rating. Good. 1202 reviews
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Rodeway Inn Fallsview
6663 Stanley Ave.,
Niagara Falls, ON, L2G 3Y9, CA
37.41 km from Depew, NY, US
3.85 stars rating. Good. 1363 reviews
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Good to know

Number of hotels

32 hotels in Depew

Highest Price

$397

Lowest Price

$68

Avg. rating

27 hotels near Depew, NY, US

Comfort Inn & Suites Buffalo Airport

Sleep Inn & Suites Buffalo Airport

Comfort Inn University

Quality Inn Near Walden Galleria Mall

Sleep Inn Amherst - Buffalo North near University

Comfort Inn & Suites Hamburg - Buffalo South

Econo Lodge Buffalo South

Cambria Hotel Niagara Falls

Curtiss Hotel, an Ascend Collection Hotel

Comfort Inn & Suites Niagara Falls Blvd USA

Quality Inn Lockport - Niagara Falls Area

Econo Lodge Darien Lakes

Comfort Inn The Pointe

Econo Lodge at the Falls North

Quality Inn - Niagara Falls Blvd

Quality Inn & Suites Palm Island Indoor Waterpark

The Giacomo, an Ascend Collection Hotel

Comfort Inn & Suites Medina NY near Erie Canal

Quality Hotel & Suites At The Falls

Comfort Inn

Comfort Inn Lundy's Lane

Comfort Hotel

Econo Lodge By the Falls

Country Inn & Suites by Radisson, Niagara Falls, ON

Comfort Inn Fallsview

Quality Hotel Fallsview Cascade

Quality Inn & Suites

Change your dates to book properties below.

Suburban Studios Buffalo Airport

CenterWay Hotel Tonawanda

Country Inn & Suites by Radisson, Buffalo South I-90, NY

Quality Inn Buffalo Airport

Rodeway Inn Fallsview

Other Depew searches

Good to know

32 hotels in Depew

$397

$68

3.6 (50670 reviews)