Book Boutique Hotels in Clayton, MO | Choice Hotels

Comfort Inn St. Louis Airport
11225 Lone Eagle Dr., Building A,
Bridgeton, MO, 63044, US
11.43 km from Clayton, MO, USA
4.05 stars rating. Very Good. 183 reviews4.05 stars rating. Very Good. 183 reviews
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Strikethrough Rate:~~$105~~Discounted rate:$88USD/night
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MainStay Suites St. Louis - Galleria
8011 Galleria Pkwy,
St. Louis, MO, 63117, US
1.92 km from Clayton, MO, USA
3.23 stars rating. Good. 182 reviews3.23 stars rating. Good. 182 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$113USD/night
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Comfort Inn St. Louis - Westport Event Center
12031 Lackland Rd.,
Saint Louis, MO, 63146, US
10.72 km from Clayton, MO, USA
3.56 stars rating. Good. 3107 reviews3.56 stars rating. Good. 3107 reviews
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Strikethrough Rate:~~$104~~Discounted rate:$92USD/night
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Comfort Inn & Suites St. Louis-Hazelwood
7133 Douglas Palmer Place,
Hazelwood, MO, 63042, US
14.48 km from Clayton, MO, USA
4.11 stars rating. Very Good. 1984 reviews4.11 stars rating. Very Good. 1984 reviews
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Strikethrough Rate:~~$97~~Discounted rate:$86USD/night
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AWARD WINNER
Comfort Suites St. Louis - Sunset Hills
3654 S. Lindbergh Blvd.,
Saint Louis, MO, 63127, US
12.37 km from Clayton, MO, USA
4.72 stars rating. Exceptional. 1907 reviews4.72 stars rating. Exceptional. 1907 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$113USD/night
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Comfort Inn & Suites Saint Louis Lafayette Square
2625 Lafayette Ave,
Saint Louis, MO, 63104-2011, US
10.69 km from Clayton, MO, USA
3.8 stars rating. Good. 108 reviews3.8 stars rating. Good. 108 reviews
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Strikethrough Rate:~~$116~~Discounted rate:$108USD/night
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Quality Inn Saint Louis Airport
10232 Natural Bridge Rd.,
Saint Louis, MO, 63134, US
9.69 km from Clayton, MO, USA
3.27 stars rating. Good. 3041 reviews3.27 stars rating. Good. 3041 reviews
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Strikethrough Rate:~~$78~~Discounted rate:$74USD/night
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Quality Inn Florissant-St. Louis
55 Dunn Road,
Florissant, MO, 63031, US
14.02 km from Clayton, MO, USA
3.41 stars rating. Good. 1455 reviews3.41 stars rating. Good. 1455 reviews
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Strikethrough Rate:~~$74~~Discounted rate:$70USD/night
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Comfort Suites St Charles-St Louis
1400 S. Fifth Street,
Saint Charles, MO, 63301, US
18.85 km from Clayton, MO, USA
4.02 stars rating. Very Good. 2079 reviews4.02 stars rating. Very Good. 2079 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$113USD/night
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Quality Inn & Suites near St. Louis and I-255
1607 Pontiac Drive,
Cahokia, IL, 62206, US
18.3 km from Clayton, MO, USA
3.54 stars rating. Good. 1347 reviews3.54 stars rating. Good. 1347 reviews
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Strikethrough Rate:~~$91~~Discounted rate:$86USD/night
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MainStay Suites St. Louis Airport
11225 Lone Eagle Dr., Building B,
Bridgeton, MO, 63044, US
11.47 km from Clayton, MO, USA
3.9 stars rating. Good. 238 reviews3.9 stars rating. Good. 238 reviews
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Strikethrough Rate:~~$110~~Discounted rate:$105USD/night
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Comfort Inn & Suites Chesterfield - St. Louis
18375 Chesterfield Arpt. Rd.,
Chesterfield, MO, 63005, US
27.48 km from Clayton, MO, USA
3.91 stars rating. Good. 2467 reviews3.91 stars rating. Good. 2467 reviews
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Strikethrough Rate:~~$103~~Discounted rate:$84USD/night
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Quality Inn O'Fallon IL - St. Louis
1409 W US 50,
O Fallon, IL, 62269, US
34.01 km from Clayton, MO, USA
3.56 stars rating. Good. 928 reviews3.56 stars rating. Good. 928 reviews
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Strikethrough Rate:~~$60~~Discounted rate:$51USD/night
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NEW TO CHOICE
Radisson Hotel St. Louis Downtown Convention Center
811 N 9th St,
St. Louis, MO, 63101, US
12.71 km from Clayton, MO, USA
1.58 stars rating. Fair. 24 reviews1.58 stars rating. Fair. 24 reviews
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Strikethrough Rate:~~$149~~Discounted rate:$142USD/night
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AWARD WINNER
Country Inn & Suites by Radisson, St. Charles Historic District
1190 South Main Street,
Saint Charles, MO, 63301, US
18.75 km from Clayton, MO, USA
4.64 stars rating. Exceptional. 626 reviews4.64 stars rating. Exceptional. 626 reviews
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Strikethrough Rate:~~$163~~Discounted rate:$155USD/night
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River City Casino & Hotel
777 River City Casino Boulevard,
Saint Louis, MO, 63125, US
14.64 km from Clayton, MO, USA
No Reviews YetNo Reviews Yet
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Strikethrough Rate:~~$215~~Discounted rate:$185USD/night
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Country Inn & Suites by Radisson, St. Peters, MO
3877 Veterans Memorial Pkwy,
Saint Peters, MO, 63376, US
25.19 km from Clayton, MO, USA
4.1 stars rating. Very Good. 220 reviews4.1 stars rating. Very Good. 220 reviews
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Strikethrough Rate:~~$99~~Discounted rate:$94USD/night
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Comfort Inn Collinsville near St. Louis
8 Commerce Dr.,
Collinsville, IL, 62234, US
28.34 km from Clayton, MO, USA
4.2 stars rating. Excellent. 1941 reviews4.2 stars rating. Excellent. 1941 reviews
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Strikethrough Rate:~~$124~~Discounted rate:$100USD/night
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Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive,
O Fallon, MO, 63368, US
32.92 km from Clayton, MO, USA
4.23 stars rating. Excellent. 1239 reviews4.23 stars rating. Excellent. 1239 reviews
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Strikethrough Rate:~~$91~~Discounted rate:$78USD/night
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Sleep Inn O'Fallon near I-64
140 Venita Drive,
O Fallon, IL, 62269, US
35.19 km from Clayton, MO, USA
3.38 stars rating. Good. 1333 reviews3.38 stars rating. Good. 1333 reviews
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Strikethrough Rate:~~$59~~Discounted rate:$56USD/night
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Sleep Inn Saint Charles North
150 Fountain Lakes Blvd.,
Saint Charles, MO, 63301, US
25.22 km from Clayton, MO, USA
3.08 stars rating. 1034 reviews3.08 stars rating. 1034 reviews
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Strikethrough Rate:~~$88~~Discounted rate:$83USD/night
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Quality Inn & Suites Caseyville - St. Louis
2180 Patricia Dr.,
Caseyville, IL, 62232, US
25.59 km from Clayton, MO, USA
2.72 stars rating. Fair. 710 reviews2.72 stars rating. Fair. 710 reviews
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Strikethrough Rate:~~$79~~Discounted rate:$75USD/night
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Econo Lodge Inn & Suites Granite City - St. Louis
3236 W. Chain of Rocks Road,
Granite City, IL, 62040, US
22.47 km from Clayton, MO, USA
3.43 stars rating. Good. 381 reviews3.43 stars rating. Good. 381 reviews
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Strikethrough Rate:~~$75~~Discounted rate:$71USD/night
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Comfort Inn Edwardsville - St. Louis
3080 S. SR 157,
Edwardsville, IL, 62025, US
31.54 km from Clayton, MO, USA
4.16 stars rating. Very Good. 1370 reviews4.16 stars rating. Very Good. 1370 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$116USD/night
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Comfort Inn & Suites St. Louis-O'Fallon
8170 Veterans Memorial Pkwy,
O Fallon, MO, 63366, US
34.05 km from Clayton, MO, USA
3.68 stars rating. Good. 1891 reviews3.68 stars rating. Good. 1891 reviews
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Strikethrough Rate:~~$85~~Discounted rate:$76USD/night
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Comfort Suites Fairview Heights - St Louis
137 Ludwig Drive,
Fairview Heights, IL, 62208, US
30.27 km from Clayton, MO, USA
3.46 stars rating. Good. 1794 reviews3.46 stars rating. Good. 1794 reviews
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Strikethrough Rate:~~$99~~Discounted rate:$94USD/night
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Econo Lodge Inn & Suites Fairview Heights - St. Louis
305 Salem Place,
Fairview Heights, IL, 62208, US
31.16 km from Clayton, MO, USA
3.74 stars rating. Good. 318 reviews3.74 stars rating. Good. 318 reviews
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Strikethrough Rate:~~$71~~Discounted rate:$63USD/night
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Comfort Inn Alton near I-255
11 Crossroads Ct.,
Alton, IL, 62002, US
33.28 km from Clayton, MO, USA
3.66 stars rating. Good. 859 reviews3.66 stars rating. Good. 859 reviews
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Strikethrough Rate:~~$104~~Discounted rate:$94USD/night
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Country Inn & Suites by Radisson, Fairview Heights, IL
140 Ludwig Drive,
Fairview Heights, IL, 62208, US
30.29 km from Clayton, MO, USA
3.21 stars rating. Good. 223 reviews3.21 stars rating. Good. 223 reviews
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Strikethrough Rate:~~$107~~Discounted rate:$97USD/night
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Quality Inn Pacific near Six Flags St. Louis
1400 West Osage St.,
Pacific, MO, 63069, US
40.91 km from Clayton, MO, USA
4 stars rating. Very Good. 657 reviews4 stars rating. Very Good. 657 reviews
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Strikethrough Rate:~~$99~~Discounted rate:$89USD/night
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Comfort Inn & Suites OFallon - St Louis Area
116 Regency Park,
O'Fallon, IL, 62269, US
35.18 km from Clayton, MO, USA
2.34 stars rating. Fair. 110 reviews2.34 stars rating. Fair. 110 reviews
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Strikethrough Rate:~~$74~~Discounted rate:$67USD/night
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Comfort Inn Near Six Flags St. Louis
1320 Thornton St.,
Pacific, MO, 63069, US
40.77 km from Clayton, MO, USA
4.05 stars rating. Very Good. 1745 reviews4.05 stars rating. Very Good. 1745 reviews
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Strikethrough Rate:~~$111~~Discounted rate:$105USD/night
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Radisson Hotel Fairview Heights - St. Louis
319 Fountains Pkwy,
Fairview Heights, IL, 62208, US
31.21 km from Clayton, MO, USA
3.12 stars rating. Good. 145 reviews3.12 stars rating. Good. 145 reviews
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Strikethrough Rate:~~$114~~Discounted rate:$108USD/night
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The Great Rivers, an Ascend Collection Hotel
3559 College Avenue,
Alton, IL, 62002, US
33.4 km from Clayton, MO, USA
2.88 stars rating. Fair. 100 reviews2.88 stars rating. Fair. 100 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$113USD/night
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Hollywood Casino St Louis
777 Casino Center Drive,
Maryland Heights, MO, 63043, US
17.1 km from Clayton, MO, USA
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Good to know

Boutique hotels

35 hotels in Clayton

Highest Price

$185

Lowest Price

$51

Avg. rating

3.4 (35746 reviews)