Extended Stay Hotels in Clayton, MO - Choice Hotels

MainStay Suites St. Louis - Galleria
8011 Galleria Pkwy,
St. Louis, MO, 63117, US
1.92 km from Clayton, MO, USA
3.23 stars rating. Good. 165 reviews3.23 stars rating. Good. 165 reviews
Book Now & Save 6%
Strikethrough Rate:~~$115~~Discounted rate:$108USD/night
Member Rate
See Availability

Below are additional hotels in the area that do not match your exact search criteria.

Comfort Inn St. Louis - Westport Event Center
12031 Lackland Rd.,
Saint Louis, MO, 63146, US
10.72 km from Clayton, MO, USA
3.57 stars rating. Good. 3077 reviews3.57 stars rating. Good. 3077 reviews
Book Now & Save 25%
Strikethrough Rate:~~$101~~Discounted rate:$75USD/night
Member Rate
See Availability
Comfort Inn St. Louis Airport
11225 Lone Eagle Dr., Building A,
Bridgeton, MO, 63044, US
11.43 km from Clayton, MO, USA
4.07 stars rating. Very Good. 176 reviews4.07 stars rating. Very Good. 176 reviews
Book Now & Save 25%
Strikethrough Rate:~~$114~~Discounted rate:$85USD/night
Special Rate
See Availability
Radisson Hotel St. Louis Downtown Convention Center
811 N 9th St,
St. Louis, MO, 63101, US
12.71 km from Clayton, MO, USA
No Reviews YetNo Reviews Yet
Book Now & Save 5%
Strikethrough Rate:~~$143~~Discounted rate:Coming soonStart booking Nov 12, 2025
Member Rate
See Availability
Stay Longer. Save More.
Say hello to WoodSpring Suites® hotels! Designed for longer stays, we offer contemporary suites with in-room kitchens and free WiFi. Plus, our affordable rates cost less per night when you stay a week, month or more.
See More Hotels
Quality Inn Airport
10232 Natural Bridge Rd.,
Saint Louis, MO, 63134, US
9.69 km from Clayton, MO, USA
3.27 stars rating. Good. 3022 reviews3.27 stars rating. Good. 3022 reviews
Book Now & Save 6%
Strikethrough Rate:~~$77~~Discounted rate:$72USD/night
Member Rate
See Availability
Quality Inn & Suites near St. Louis and I-255
1607 Pontiac Drive,
Cahokia, IL, 62206, US
18.3 km from Clayton, MO, USA
3.54 stars rating. Good. 1344 reviews3.54 stars rating. Good. 1344 reviews
Book Now & Save 25%
Strikethrough Rate:~~$89~~Discounted rate:$67USD/night
Member Rate
See Availability
Comfort Suites St. Louis - Sunset Hills
3654 S. Lindbergh Blvd.,
Saint Louis, MO, 63127, US
12.37 km from Clayton, MO, USA
4.71 stars rating. Exceptional. 1832 reviews4.71 stars rating. Exceptional. 1832 reviews
Book Now & Save 6%
Strikethrough Rate:~~$120~~Discounted rate:$112USD/night
Member Rate
See Availability
Quality Inn Florissant-St. Louis
55 Dunn Road,
Florissant, MO, 63031, US
14.02 km from Clayton, MO, USA
3.41 stars rating. Good. 1447 reviews3.41 stars rating. Good. 1447 reviews
Book Now & Save 6%
Strikethrough Rate:~~$75~~Discounted rate:$70USD/night
Member Rate
See Availability
Comfort Inn & Suites St. Louis-Hazelwood
7133 Douglas Palmer Place,
Hazelwood, MO, 63042, US
14.48 km from Clayton, MO, USA
4.12 stars rating. Very Good. 1975 reviews4.12 stars rating. Very Good. 1975 reviews
Book Now & Save 16%
Strikethrough Rate:~~$102~~Discounted rate:$86USD/night
Member Rate
See Availability
Comfort Inn & Suites
2625 Lafayette Ave,
Saint Louis, MO, 63104-2011, US
10.69 km from Clayton, MO, USA
3.82 stars rating. Good. 92 reviews3.82 stars rating. Good. 92 reviews
Book Now & Save 7%
Strikethrough Rate:~~$124~~Discounted rate:$115USD/night
Member Rate
See Availability
River City Casino & Hotel
777 River City Casino Boulevard,
Saint Louis, MO, 63125, US
14.64 km from Clayton, MO, USA
No Reviews YetNo Reviews Yet
Book Now & Save 14%
Strikethrough Rate:~~$161~~Discounted rate:$139USD/night
Member Rate
Fees included
See Availability
Comfort Suites St Charles-St Louis
1400 S. Fifth Street,
Saint Charles, MO, 63301, US
18.85 km from Clayton, MO, USA
4.03 stars rating. Very Good. 2063 reviews4.03 stars rating. Very Good. 2063 reviews
Book Now & Save 20%
Strikethrough Rate:~~$114~~Discounted rate:$91USD/night
Member Rate
See Availability
Comfort Inn & Suites Chesterfield - St. Louis
18375 Chesterfield Arpt. Rd.,
Chesterfield, MO, 63005, US
27.48 km from Clayton, MO, USA
3.92 stars rating. Good. 2441 reviews3.92 stars rating. Good. 2441 reviews
Book Now & Save 27%
Strikethrough Rate:~~$116~~Discounted rate:$85USD/night
Member Rate
Fees included
See Availability
Quality Inn & Suites Caseyville - St. Louis
2180 Patricia Dr.,
Caseyville, IL, 62232, US
25.59 km from Clayton, MO, USA
2.73 stars rating. Fair. 705 reviews2.73 stars rating. Fair. 705 reviews
Book Now & Save 25%
Strikethrough Rate:~~$75~~Discounted rate:$56USD/night
Member Rate
See Availability
Country Inn & Suites by Radisson, St. Charles Historic District
1190 South Main Street,
Saint Charles, MO, 63301, US
18.75 km from Clayton, MO, USA
4.65 stars rating. Exceptional. 565 reviews4.65 stars rating. Exceptional. 565 reviews
Book Now & Save 6%
Strikethrough Rate:~~$167~~Discounted rate:$156USD/night
Member Rate
See Availability
Hollywood Casino St Louis
777 Casino Center Drive,
Maryland Heights, MO, 63043, US
17.1 km from Clayton, MO, USA
No Reviews YetNo Reviews Yet
$149USD/night
Fees included
See Availability
Comfort Inn Collinsville near St. Louis
8 Commerce Dr.,
Collinsville, IL, 62234, US
28.34 km from Clayton, MO, USA
4.19 stars rating. Very Good. 1915 reviews4.19 stars rating. Very Good. 1915 reviews
Book Now & Save 28%
Strikethrough Rate:~~$119~~Discounted rate:$86USD/night
Member Rate
See Availability
Econo Lodge Inn & Suites
3236 W. Chain of Rocks Road,
Granite City, IL, 62040, US
22.47 km from Clayton, MO, USA
3.43 stars rating. Good. 373 reviews3.43 stars rating. Good. 373 reviews
Book Now & Save 6%
Strikethrough Rate:~~$73~~Discounted rate:$68USD/night
Member Rate
See Availability
Country Inn & Suites by Radisson, Fairview Heights, IL
140 Ludwig Drive,
Fairview Heights, IL, 62208, US
30.29 km from Clayton, MO, USA
3.19 stars rating. Good. 218 reviews3.19 stars rating. Good. 218 reviews
Book Now & Save 33%
Strikethrough Rate:~~$102~~Discounted rate:$69USD/night
Member Rate
See Availability
Quality Inn O'Fallon IL - St. Louis
1409 W US 50,
O Fallon, IL, 62269, US
34.01 km from Clayton, MO, USA
3.56 stars rating. Good. 923 reviews3.56 stars rating. Good. 923 reviews
Book Now & Save 15%
Strikethrough Rate:~~$69~~Discounted rate:$59USD/night
Member Rate
See Availability
Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive,
O Fallon, MO, 63368, US
32.92 km from Clayton, MO, USA
4.23 stars rating. Excellent. 1217 reviews4.23 stars rating. Excellent. 1217 reviews
Book Now & Save 24%
Strikethrough Rate:~~$100~~Discounted rate:$77USD/night
Member Rate
See Availability
Sleep Inn
150 Fountain Lakes Blvd.,
Saint Charles, MO, 63301, US
25.22 km from Clayton, MO, USA
3.08 stars rating. 1020 reviews3.08 stars rating. 1020 reviews
Book Now & Save 6%
Strikethrough Rate:~~$86~~Discounted rate:$81USD/night
Member Rate
See Availability
Country Inn & Suites by Radisson, St. Peters, MO
3877 Veterans Memorial Pkwy,
Saint Peters, MO, 63376, US
25.19 km from Clayton, MO, USA
4.12 stars rating. Very Good. 207 reviews4.12 stars rating. Very Good. 207 reviews
Book Now & Save 6%
Strikethrough Rate:~~$114~~Discounted rate:$107USD/night
Member Rate
See Availability
Comfort Suites Fairview Heights - St Louis
137 Ludwig Drive,
Fairview Heights, IL, 62208, US
30.27 km from Clayton, MO, USA
3.46 stars rating. Good. 1775 reviews3.46 stars rating. Good. 1775 reviews
Book Now & Save 25%
Strikethrough Rate:~~$100~~Discounted rate:$75USD/night
Member Rate
See Availability
Comfort Inn Edwardsville - St. Louis
3080 S. SR 157,
Edwardsville, IL, 62025, US
31.54 km from Clayton, MO, USA
4.17 stars rating. Very Good. 1364 reviews4.17 stars rating. Very Good. 1364 reviews
Book Now & Save 10%
Strikethrough Rate:~~$129~~Discounted rate:$116USD/night
Member Rate
See Availability
Comfort Inn Alton near I-255
11 Crossroads Ct.,
Alton, IL, 62002, US
33.28 km from Clayton, MO, USA
3.66 stars rating. Good. 854 reviews3.66 stars rating. Good. 854 reviews
Book Now & Save 24%
Strikethrough Rate:~~$97~~Discounted rate:$74USD/night
Member Rate
See Availability
Sleep Inn O'Fallon near I-64
140 Venita Drive,
O Fallon, IL, 62269, US
35.19 km from Clayton, MO, USA
3.39 stars rating. Good. 1322 reviews3.39 stars rating. Good. 1322 reviews
Book Now & Save 11%
Strikethrough Rate:~~$74~~Discounted rate:$66USD/night
Member Rate
See Availability
Comfort Inn & Suites St. Louis-O'Fallon
100 Comfort Inn Court,
O Fallon, MO, 63366, US
34.05 km from Clayton, MO, USA
3.68 stars rating. Good. 1862 reviews3.68 stars rating. Good. 1862 reviews
Book Now & Save 10%
Strikethrough Rate:~~$92~~Discounted rate:$83USD/night
Member Rate
See Availability
Econo Lodge Inn & Suites Fairview Heights - St. Louis
305 Salem Place,
Fairview Heights, IL, 62208, US
31.16 km from Clayton, MO, USA
3.74 stars rating. Good. 316 reviews3.74 stars rating. Good. 316 reviews
Book Now & Save 6%
Strikethrough Rate:~~$76~~Discounted rate:$71USD/night
Member Rate
See Availability
Comfort Inn & Suites OFallon - St Louis Area
116 Regency Park,
O'Fallon, IL, 62269, US
35.18 km from Clayton, MO, USA
2.33 stars rating. Fair. 99 reviews2.33 stars rating. Fair. 99 reviews
Book Now & Save 28%
Strikethrough Rate:~~$93~~Discounted rate:$67USD/night
Member Rate
See Availability
Radisson Hotel Fairview Heights - St. Louis
319 Fountains Pkwy,
Fairview Heights, IL, 62208, US
31.21 km from Clayton, MO, USA
3.12 stars rating. Good. 131 reviews3.12 stars rating. Good. 131 reviews
Book Now & Save 10%
Strikethrough Rate:~~$110~~Discounted rate:$99USD/night
Special Rate
See Availability
The Great Rivers, an Ascend Collection Hotel
3559 College Avenue,
Alton, IL, 62002, US
33.4 km from Clayton, MO, USA
2.81 stars rating. Fair. 91 reviews2.81 stars rating. Fair. 91 reviews
Book Now & Save 5%
Strikethrough Rate:~~$118~~Discounted rate:$112USD/night
Member Rate
See Availability
Comfort Inn Near Six Flags St. Louis
1320 Thornton St.,
Pacific, MO, 63069, US
40.77 km from Clayton, MO, USA
4.05 stars rating. Very Good. 1721 reviews4.05 stars rating. Very Good. 1721 reviews
Book Now & Save 6%
Strikethrough Rate:~~$127~~Discounted rate:$119USD/night
Member Rate
See Availability
Quality Inn Near Six Flags St. Louis
1400 West Osage St.,
Pacific, MO, 63069, US
40.91 km from Clayton, MO, USA
4 stars rating. Very Good. 653 reviews4 stars rating. Very Good. 653 reviews
Book Now & Save 10%
Strikethrough Rate:~~$118~~Discounted rate:$106USD/night
Member Rate
See Availability

Change your dates to book properties below.

MainStay Suites St. Louis Airport
11225 Lone Eagle Dr., Building B,
Bridgeton, MO, 63044, US
11.47 km from Clayton, MO, USA
3.93 stars rating. Good. 234 reviews3.93 stars rating. Good. 234 reviews
Sold outfor your selected dates
See Availability

Other Clayton searches

All Hotels in Clayton

Boutique Hotels in Clayton

Hotel Deals in Clayton

Pet Friendly Hotels in Clayton

Top Rated Hotels in Clayton

Good to know

Extended stay hotels

2 of 35 hotels in Clayton

Highest Price

$156

Lowest Price

$56

Avg. rating

3.3 (35199 reviews)

Weekly Rate

$392

Monthly Rate

$1,680