Extended Stay Hotels in Saint Charles, MO - Choice Hotels

MainStay Suites St. Louis Airport
11225 Lone Eagle Dr., Building B,
Bridgeton, MO, 63044, US
5.33 mi from St Charles, MO, USA
3.93 stars rating. Good. 234 reviews3.93 stars rating. Good. 234 reviews
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Strikethrough Rate:~~$164~~Discounted rate:$115USD/night
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MainStay Suites St. Louis - Galleria
8011 Galleria Pkwy,
St. Louis, MO, 63117, US
12.74 mi from St Charles, MO, USA
3.24 stars rating. Good. 161 reviews3.24 stars rating. Good. 161 reviews
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Strikethrough Rate:~~$90~~Discounted rate:$84USD/night
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Below are additional hotels in the area that do not match your exact search criteria.

Sleep Inn
150 Fountain Lakes Blvd.,
Saint Charles, MO, 63301, US
3.62 mi from St Charles, MO, USA
3.08 stars rating. 1017 reviews3.08 stars rating. 1017 reviews
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Strikethrough Rate:~~$88~~Discounted rate:$82USD/night
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Comfort Inn St. Louis - Westport Event Center
12031 Lackland Rd.,
Saint Louis, MO, 63146, US
6.22 mi from St Charles, MO, USA
3.58 stars rating. Good. 3057 reviews3.58 stars rating. Good. 3057 reviews
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Strikethrough Rate:~~$103~~Discounted rate:$77USD/night
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Stay Longer. Save More.
Say hello to WoodSpring Suites® hotels! Designed for longer stays, we offer contemporary suites with in-room kitchens and free WiFi. Plus, our affordable rates cost less per night when you stay a week, month or more.
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Comfort Inn St. Louis Airport
11225 Lone Eagle Dr., Building A,
Bridgeton, MO, 63044, US
5.34 mi from St Charles, MO, USA
4.09 stars rating. Very Good. 172 reviews4.09 stars rating. Very Good. 172 reviews
Book Now & Save 25%
Strikethrough Rate:~~$125~~Discounted rate:$93USD/night
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Country Inn & Suites by Radisson, St. Charles Historic District
1190 South Main Street,
Saint Charles, MO, 63301, US
0.8 mi from St Charles, MO, USA
4.65 stars rating. Exceptional. 533 reviews4.65 stars rating. Exceptional. 533 reviews
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Strikethrough Rate:~~$190~~Discounted rate:$178USD/night
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Comfort Suites St Charles-St Louis
1400 S. Fifth Street,
Saint Charles, MO, 63301, US
1.14 mi from St Charles, MO, USA
4.03 stars rating. Very Good. 2050 reviews4.03 stars rating. Very Good. 2050 reviews
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Strikethrough Rate:~~$134~~Discounted rate:$126USD/night
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Comfort Inn & Suites St. Louis-Hazelwood
7133 Douglas Palmer Place,
Hazelwood, MO, 63042, US
6.76 mi from St Charles, MO, USA
4.12 stars rating. Very Good. 1973 reviews4.12 stars rating. Very Good. 1973 reviews
Book Now & Save 16%
Strikethrough Rate:~~$104~~Discounted rate:$88USD/night
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Quality Inn Florissant-St. Louis
55 Dunn Road,
Florissant, MO, 63031, US
7.85 mi from St Charles, MO, USA
3.42 stars rating. Good. 1437 reviews3.42 stars rating. Good. 1437 reviews
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Strikethrough Rate:~~$80~~Discounted rate:$75USD/night
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Quality Inn Airport
10232 Natural Bridge Rd.,
Saint Louis, MO, 63134, US
7.43 mi from St Charles, MO, USA
3.28 stars rating. Good. 3011 reviews3.28 stars rating. Good. 3011 reviews
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Strikethrough Rate:~~$84~~Discounted rate:$79USD/night
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Hollywood Casino St Louis
777 Casino Center Drive,
Maryland Heights, MO, 63043, US
2.03 mi from St Charles, MO, USA
No Reviews YetNo Reviews Yet
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Strikethrough Rate:~~$199~~Discounted rate:$163USD/night
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Fees included
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Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive,
O Fallon, MO, 63368, US
12.95 mi from St Charles, MO, USA
4.23 stars rating. Excellent. 1206 reviews4.23 stars rating. Excellent. 1206 reviews
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Strikethrough Rate:~~$111~~Discounted rate:$85USD/night
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Comfort Inn & Suites St. Louis-O'Fallon
100 Comfort Inn Court,
O Fallon, MO, 63366, US
10.68 mi from St Charles, MO, USA
3.69 stars rating. Good. 1849 reviews3.69 stars rating. Good. 1849 reviews
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Strikethrough Rate:~~$115~~Discounted rate:$104USD/night
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Comfort Inn & Suites Chesterfield - St. Louis
18375 Chesterfield Arpt. Rd.,
Chesterfield, MO, 63005, US
11.95 mi from St Charles, MO, USA
3.93 stars rating. Good. 2430 reviews3.93 stars rating. Good. 2430 reviews
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Strikethrough Rate:~~$123~~Discounted rate:$106USD/night
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Fees included
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Quality Inn & Suites Caseyville - St. Louis
2180 Patricia Dr.,
Caseyville, IL, 62232, US
26.26 mi from St Charles, MO, USA
2.74 stars rating. Fair. 703 reviews2.74 stars rating. Fair. 703 reviews
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Strikethrough Rate:~~$79~~Discounted rate:$59USD/night
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Quality Inn O'Fallon IL - St. Louis
1409 W US 50,
O Fallon, IL, 62269, US
31.42 mi from St Charles, MO, USA
3.57 stars rating. Good. 913 reviews3.57 stars rating. Good. 913 reviews
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Strikethrough Rate:~~$70~~Discounted rate:$60USD/night
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Radisson Hotel Fairview Heights - St. Louis
319 Fountains Pkwy,
Fairview Heights, IL, 62208, US
29.6 mi from St Charles, MO, USA
3.1 stars rating. Good. 126 reviews3.1 stars rating. Good. 126 reviews
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Strikethrough Rate:~~$95~~Discounted rate:$80USD/night
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Comfort Inn & Suites OFallon - St Louis Area
116 Regency Park,
O'Fallon, IL, 62269, US
32.12 mi from St Charles, MO, USA
2.35 stars rating. Fair. 94 reviews2.35 stars rating. Fair. 94 reviews
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Strikethrough Rate:~~$90~~Discounted rate:$65USD/night
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Comfort Inn Alton near I-255
11 Crossroads Ct.,
Alton, IL, 62002, US
20.56 mi from St Charles, MO, USA
3.68 stars rating. Good. 842 reviews3.68 stars rating. Good. 842 reviews
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Strikethrough Rate:~~$127~~Discounted rate:$97USD/night
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Econo Lodge Inn & Suites
3236 W. Chain of Rocks Road,
Granite City, IL, 62040, US
19.44 mi from St Charles, MO, USA
3.44 stars rating. Good. 369 reviews3.44 stars rating. Good. 369 reviews
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Strikethrough Rate:~~$76~~Discounted rate:$71USD/night
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Sleep Inn O'Fallon near I-64
140 Venita Drive,
O Fallon, IL, 62269, US
32.07 mi from St Charles, MO, USA
3.39 stars rating. Good. 1315 reviews3.39 stars rating. Good. 1315 reviews
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Strikethrough Rate:~~$75~~Discounted rate:$67USD/night
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Comfort Suites Fairview Heights - St Louis
137 Ludwig Drive,
Fairview Heights, IL, 62208, US
29.12 mi from St Charles, MO, USA
3.46 stars rating. Good. 1770 reviews3.46 stars rating. Good. 1770 reviews
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Strikethrough Rate:~~$98~~Discounted rate:$73USD/night
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Econo Lodge Inn & Suites Fairview Heights - St. Louis
305 Salem Place,
Fairview Heights, IL, 62208, US
29.61 mi from St Charles, MO, USA
3.73 stars rating. Good. 314 reviews3.73 stars rating. Good. 314 reviews
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Strikethrough Rate:~~$75~~Discounted rate:$67USD/night
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Comfort Inn & Suites
2625 Lafayette Ave,
Saint Louis, MO, 63104-2011, US
18.17 mi from St Charles, MO, USA
3.79 stars rating. Good. 90 reviews3.79 stars rating. Good. 90 reviews
Book Now & Save 7%
Strikethrough Rate:~~$134~~Discounted rate:$124USD/night
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Country Inn & Suites by Radisson, Fairview Heights, IL
140 Ludwig Drive,
Fairview Heights, IL, 62208, US
29.14 mi from St Charles, MO, USA
3.21 stars rating. Good. 214 reviews3.21 stars rating. Good. 214 reviews
Book Now & Save 24%
Strikethrough Rate:~~$112~~Discounted rate:$86USD/night
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Quality Inn
12 Highway W,
Foristell, MO, 63348, US
25.46 mi from St Charles, MO, USA
4.22 stars rating. Excellent. 914 reviews4.22 stars rating. Excellent. 914 reviews
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Strikethrough Rate:~~$128~~Discounted rate:$115USD/night
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Quality Inn & Suites near St. Louis and I-255
1607 Pontiac Drive,
Cahokia, IL, 62206, US
23.23 mi from St Charles, MO, USA
3.54 stars rating. Good. 1338 reviews3.54 stars rating. Good. 1338 reviews
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Strikethrough Rate:~~$97~~Discounted rate:$72USD/night
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River City Casino & Hotel
777 River City Casino Boulevard,
Saint Louis, MO, 63125, US
20.99 mi from St Charles, MO, USA
No Reviews YetNo Reviews Yet
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Strikethrough Rate:~~$172~~Discounted rate:$149USD/night
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Quality Inn Near Six Flags St. Louis
1400 West Osage St.,
Pacific, MO, 63069, US
25.45 mi from St Charles, MO, USA
4 stars rating. Very Good. 649 reviews4 stars rating. Very Good. 649 reviews
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Strikethrough Rate:~~$128~~Discounted rate:$115USD/night
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Comfort Inn Collinsville near St. Louis
8 Commerce Dr.,
Collinsville, IL, 62234, US
26.13 mi from St Charles, MO, USA
4.19 stars rating. Very Good. 1906 reviews4.19 stars rating. Very Good. 1906 reviews
Book Now & Save 28%
Strikethrough Rate:~~$154~~Discounted rate:$111USD/night
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Comfort Inn Edwardsville - St. Louis
3080 S. SR 157,
Edwardsville, IL, 62025, US
25.71 mi from St Charles, MO, USA
4.17 stars rating. Very Good. 1352 reviews4.17 stars rating. Very Good. 1352 reviews
Book Now & Save 24%
Strikethrough Rate:~~$147~~Discounted rate:$112USD/night
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The Great Rivers, an Ascend Collection Hotel
3559 College Avenue,
Alton, IL, 62002, US
20.63 mi from St Charles, MO, USA
2.79 stars rating. Fair. 81 reviews2.79 stars rating. Fair. 81 reviews
Book Now & Save 5%
Strikethrough Rate:~~$127~~Discounted rate:$120USD/night
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Comfort Inn Festus-St. Louis South
1303 Veterans Blvd.,
Festus, MO, 63028, US
39.55 mi from St Charles, MO, USA
3.99 stars rating. Good. 1284 reviews3.99 stars rating. Good. 1284 reviews
Book Now & Save 10%
Strikethrough Rate:~~$130~~Discounted rate:$117USD/night
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Country Inn & Suites by Radisson, St. Peters, MO
3877 Veterans Memorial Pkwy,
Saint Peters, MO, 63376, US
4.43 mi from St Charles, MO, USA
4.12 stars rating. Very Good. 202 reviews4.12 stars rating. Very Good. 202 reviews
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Comfort Suites St. Louis - Sunset Hills
3654 S. Lindbergh Blvd.,
Saint Louis, MO, 63127, US
16.45 mi from St Charles, MO, USA
4.71 stars rating. Exceptional. 1800 reviews4.71 stars rating. Exceptional. 1800 reviews
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Radisson Hotel St. Louis Downtown Convention Center
811 N 9th St,
St. Louis, MO, 63101, US
18.73 mi from St Charles, MO, USA
No Reviews YetNo Reviews Yet
Coming soonStart booking Oct 29, 2026
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Comfort Inn Near Six Flags St. Louis
1320 Thornton St.,
Pacific, MO, 63069, US
25.33 mi from St Charles, MO, USA
4.05 stars rating. Very Good. 1699 reviews4.05 stars rating. Very Good. 1699 reviews
Sold outfor your selected dates
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Good to know

Extended stay hotels

2 of 37 hotels in Saint Charles

Highest Price

$178

Lowest Price

$59

Avg. rating

3.4 (37105 reviews)

Weekly Rate

$413

Monthly Rate

$1,770