Hotels in Saint Charles, MO

Country Inn & Suites by Radisson, St. Charles Historic District
1190 South Main Street,
Saint Charles, MO, 63301, US
1.28 km from St Charles, MO, USA
4.65 stars rating. Exceptional. 533 reviews4.65 stars rating. Exceptional. 533 reviews
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Strikethrough Rate:~~$124~~Discounted rate:$115USD/night
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Comfort Suites St Charles-St Louis
1400 S. Fifth Street,
Saint Charles, MO, 63301, US
1.84 km from St Charles, MO, USA
4.03 stars rating. Very Good. 2050 reviews4.03 stars rating. Very Good. 2050 reviews
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Strikethrough Rate:~~$109~~Discounted rate:$96USD/night
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Comfort Inn & Suites St. Louis-Hazelwood
7133 Douglas Palmer Place,
Hazelwood, MO, 63042, US
10.88 km from St Charles, MO, USA
4.12 stars rating. Very Good. 1973 reviews4.12 stars rating. Very Good. 1973 reviews
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Strikethrough Rate:~~$94~~Discounted rate:$83USD/night
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Country Inn & Suites by Radisson, St. Peters, MO
3877 Veterans Memorial Pkwy,
Saint Peters, MO, 63376, US
7.13 km from St Charles, MO, USA
4.12 stars rating. Very Good. 202 reviews4.12 stars rating. Very Good. 202 reviews
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Strikethrough Rate:~~$105~~Discounted rate:$97USD/night
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Hollywood Casino St Louis
777 Casino Center Drive,
Maryland Heights, MO, 63043, US
3.27 km from St Charles, MO, USA
No Reviews YetNo Reviews Yet
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Strikethrough Rate:~~$165~~Discounted rate:$135USD/night
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Comfort Inn St. Louis - Westport Event Center
12031 Lackland Rd.,
Saint Louis, MO, 63146, US
10.01 km from St Charles, MO, USA
3.58 stars rating. Good. 3056 reviews3.58 stars rating. Good. 3056 reviews
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Strikethrough Rate:~~$94~~Discounted rate:$83USD/night
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Comfort Inn St. Louis Airport
11225 Lone Eagle Dr., Building A,
Bridgeton, MO, 63044, US
8.6 km from St Charles, MO, USA
4.09 stars rating. Very Good. 171 reviews4.09 stars rating. Very Good. 171 reviews
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Strikethrough Rate:~~$109~~Discounted rate:$91USD/night
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Sleep Inn
150 Fountain Lakes Blvd.,
Saint Charles, MO, 63301, US
5.82 km from St Charles, MO, USA
3.08 stars rating. 1017 reviews3.08 stars rating. 1017 reviews
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Strikethrough Rate:~~$86~~Discounted rate:$80USD/night
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Quality Inn Florissant-St. Louis
55 Dunn Road,
Florissant, MO, 63031, US
12.64 km from St Charles, MO, USA
3.42 stars rating. Good. 1437 reviews3.42 stars rating. Good. 1437 reviews
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Strikethrough Rate:~~$75~~Discounted rate:$70USD/night
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Comfort Inn & Suites St. Louis-O'Fallon
100 Comfort Inn Court,
O Fallon, MO, 63366, US
17.19 km from St Charles, MO, USA
3.69 stars rating. Good. 1848 reviews3.69 stars rating. Good. 1848 reviews
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Strikethrough Rate:~~$90~~Discounted rate:$81USD/night
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Quality Inn Airport
10232 Natural Bridge Rd.,
Saint Louis, MO, 63134, US
11.96 km from St Charles, MO, USA
3.28 stars rating. Good. 3011 reviews3.28 stars rating. Good. 3011 reviews
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Strikethrough Rate:~~$80~~Discounted rate:$74USD/night
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Comfort Inn & Suites Chesterfield - St. Louis
18375 Chesterfield Arpt. Rd.,
Chesterfield, MO, 63005, US
19.24 km from St Charles, MO, USA
3.93 stars rating. Good. 2430 reviews3.93 stars rating. Good. 2430 reviews
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Strikethrough Rate:~~$113~~Discounted rate:$97USD/night
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MainStay Suites St. Louis Airport
11225 Lone Eagle Dr., Building B,
Bridgeton, MO, 63044, US
8.58 km from St Charles, MO, USA
3.93 stars rating. Good. 234 reviews3.93 stars rating. Good. 234 reviews
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Strikethrough Rate:~~$116~~Discounted rate:$97USD/night
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Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive,
O Fallon, MO, 63368, US
20.84 km from St Charles, MO, USA
4.23 stars rating. Excellent. 1206 reviews4.23 stars rating. Excellent. 1206 reviews
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Strikethrough Rate:~~$104~~Discounted rate:$89USD/night
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Comfort Suites St. Louis - Sunset Hills
3654 S. Lindbergh Blvd.,
Saint Louis, MO, 63127, US
26.48 km from St Charles, MO, USA
4.71 stars rating. Exceptional. 1800 reviews4.71 stars rating. Exceptional. 1800 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$111USD/night
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Comfort Inn Alton near I-255
11 Crossroads Ct.,
Alton, IL, 62002, US
33.09 km from St Charles, MO, USA
3.68 stars rating. Good. 842 reviews3.68 stars rating. Good. 842 reviews
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Strikethrough Rate:~~$87~~Discounted rate:$78USD/night
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Econo Lodge Inn & Suites
3236 W. Chain of Rocks Road,
Granite City, IL, 62040, US
31.29 km from St Charles, MO, USA
3.44 stars rating. Good. 369 reviews3.44 stars rating. Good. 369 reviews
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Strikethrough Rate:~~$70~~Discounted rate:$65USD/night
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MainStay Suites St. Louis - Galleria
8011 Galleria Pkwy,
St. Louis, MO, 63117, US
20.5 km from St Charles, MO, USA
3.24 stars rating. Good. 161 reviews3.24 stars rating. Good. 161 reviews
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Strikethrough Rate:~~$149~~Discounted rate:$125USD/night
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Quality Inn & Suites near St. Louis and I-255
1607 Pontiac Drive,
Cahokia, IL, 62206, US
37.38 km from St Charles, MO, USA
3.54 stars rating. Good. 1338 reviews3.54 stars rating. Good. 1338 reviews
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Strikethrough Rate:~~$85~~Discounted rate:$79USD/night
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Comfort Inn & Suites
2625 Lafayette Ave,
Saint Louis, MO, 63104-2011, US
29.25 km from St Charles, MO, USA
3.79 stars rating. Good. 90 reviews3.79 stars rating. Good. 90 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$120USD/night
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River City Casino & Hotel
777 River City Casino Boulevard,
Saint Louis, MO, 63125, US
33.79 km from St Charles, MO, USA
No Reviews YetNo Reviews Yet
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Strikethrough Rate:~~$165~~Discounted rate:$135USD/night
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The Great Rivers, an Ascend Collection Hotel
3559 College Avenue,
Alton, IL, 62002, US
33.19 km from St Charles, MO, USA
2.79 stars rating. Fair. 81 reviews2.79 stars rating. Fair. 81 reviews
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Strikethrough Rate:~~$99~~Discounted rate:$94USD/night
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Radisson Hotel St. Louis Downtown Convention Center
811 N 9th St,
St. Louis, MO, 63101, US
30.14 km from St Charles, MO, USA
No Reviews YetNo Reviews Yet
Coming soonStart booking 29 Oct 2026
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Good to know

Number of hotels

23 hotels in Saint Charles

Highest Price

$135

Lowest Price

$65

Avg. rating

22 hotels near St Charles, MO, USA

Country Inn & Suites by Radisson, St. Charles Historic District

Comfort Suites St Charles-St Louis

Comfort Inn & Suites St. Louis-Hazelwood

Country Inn & Suites by Radisson, St. Peters, MO

Hollywood Casino St Louis

Comfort Inn St. Louis - Westport Event Center

Comfort Inn St. Louis Airport

Sleep Inn

Quality Inn Florissant-St. Louis

Comfort Inn & Suites St. Louis-O'Fallon

Quality Inn Airport

Comfort Inn & Suites Chesterfield - St. Louis

MainStay Suites St. Louis Airport

Sleep Inn & Suites O'Fallon MO - Technology Drive

Comfort Suites St. Louis - Sunset Hills

Comfort Inn Alton near I-255

Econo Lodge Inn & Suites

MainStay Suites St. Louis - Galleria

Quality Inn & Suites near St. Louis and I-255

Comfort Inn & Suites

River City Casino & Hotel

The Great Rivers, an Ascend Collection Hotel

Change your dates to book properties below.

Radisson Hotel St. Louis Downtown Convention Center

Other Saint Charles searches

Good to know

23 hotels in Saint Charles

$135

$65

3.3 (23849 reviews)