Hotels in Saint Charles, MO – Choice Hotels

Comfort Suites St Charles-St Louis
1400 S. Fifth Street,
Saint Charles, MO, 63301, US
1.84 km from St Charles, MO, USA
4.03 stars rating. Very Good. 2053 reviews4.03 stars rating. Very Good. 2053 reviews
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Strikethrough Rate:~~$124~~Discounted rate:$115USD/night
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Comfort Inn & Suites St. Louis-Hazelwood
7133 Douglas Palmer Place,
Hazelwood, MO, 63042, US
10.88 km from St Charles, MO, USA
4.12 stars rating. Very Good. 1973 reviews4.12 stars rating. Very Good. 1973 reviews
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Strikethrough Rate:~~$95~~Discounted rate:$84USD/night
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Comfort Inn St. Louis - Westport Event Center
12031 Lackland Rd.,
Saint Louis, MO, 63146, US
10.01 km from St Charles, MO, USA
3.58 stars rating. Good. 3060 reviews3.58 stars rating. Good. 3060 reviews
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Strikethrough Rate:~~$99~~Discounted rate:$87USD/night
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Sleep Inn
150 Fountain Lakes Blvd.,
Saint Charles, MO, 63301, US
5.82 km from St Charles, MO, USA
3.08 stars rating. 1017 reviews3.08 stars rating. 1017 reviews
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Strikethrough Rate:~~$86~~Discounted rate:$80USD/night
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Comfort Inn & Suites St. Louis-O'Fallon
100 Comfort Inn Court,
O Fallon, MO, 63366, US
17.19 km from St Charles, MO, USA
3.69 stars rating. Good. 1853 reviews3.69 stars rating. Good. 1853 reviews
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Strikethrough Rate:~~$86~~Discounted rate:$77USD/night
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Comfort Inn & Suites Chesterfield - St. Louis
18375 Chesterfield Arpt. Rd.,
Chesterfield, MO, 63005, US
19.24 km from St Charles, MO, USA
3.93 stars rating. Good. 2434 reviews3.93 stars rating. Good. 2434 reviews
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Strikethrough Rate:~~$109~~Discounted rate:$93USD/night
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Quality Inn Airport
10232 Natural Bridge Rd.,
Saint Louis, MO, 63134, US
11.96 km from St Charles, MO, USA
3.28 stars rating. Good. 3014 reviews3.28 stars rating. Good. 3014 reviews
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Strikethrough Rate:~~$130~~Discounted rate:$121USD/night
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Comfort Inn Alton near I-255
11 Crossroads Ct.,
Alton, IL, 62002, US
33.09 km from St Charles, MO, USA
3.67 stars rating. Good. 848 reviews3.67 stars rating. Good. 848 reviews
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Strikethrough Rate:~~$99~~Discounted rate:$89USD/night
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Comfort Suites Fairview Heights - St Louis
137 Ludwig Drive,
Fairview Heights, IL, 62208, US
46.86 km from St Charles, MO, USA
3.46 stars rating. Good. 1772 reviews3.46 stars rating. Good. 1772 reviews
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Strikethrough Rate:~~$99~~Discounted rate:$92USD/night
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Comfort Inn & Suites
2625 Lafayette Ave,
Saint Louis, MO, 63104-2011, US
29.25 km from St Charles, MO, USA
3.8 stars rating. Good. 91 reviews3.8 stars rating. Good. 91 reviews
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Strikethrough Rate:~~$123~~Discounted rate:$115USD/night
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Comfort Inn Collinsville near St. Louis
8 Commerce Dr.,
Collinsville, IL, 62234, US
42.06 km from St Charles, MO, USA
4.19 stars rating. Very Good. 1907 reviews4.19 stars rating. Very Good. 1907 reviews
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Strikethrough Rate:~~$117~~Discounted rate:$95USD/night
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Quality Inn & Suites near St. Louis and I-255
1607 Pontiac Drive,
Cahokia, IL, 62206, US
37.38 km from St Charles, MO, USA
3.54 stars rating. Good. 1342 reviews3.54 stars rating. Good. 1342 reviews
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Strikethrough Rate:~~$84~~Discounted rate:$78USD/night
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Quality Inn Near Six Flags St. Louis
1400 West Osage St.,
Pacific, MO, 63069, US
40.96 km from St Charles, MO, USA
4 stars rating. Very Good. 651 reviews4 stars rating. Very Good. 651 reviews
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Strikethrough Rate:~~$99~~Discounted rate:$89USD/night
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Quality Inn
12 Highway W,
Foristell, MO, 63348, US
40.97 km from St Charles, MO, USA
4.22 stars rating. Excellent. 918 reviews4.22 stars rating. Excellent. 918 reviews
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Strikethrough Rate:~~$105~~Discounted rate:$95USD/night
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Quality Inn & Suites Caseyville - St. Louis
2180 Patricia Dr.,
Caseyville, IL, 62232, US
42.27 km from St Charles, MO, USA
2.73 stars rating. Fair. 704 reviews2.73 stars rating. Fair. 704 reviews
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Strikethrough Rate:~~$76~~Discounted rate:$71USD/night
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Comfort Inn Near Six Flags St. Louis
1320 Thornton St.,
Pacific, MO, 63069, US
40.77 km from St Charles, MO, USA
4.05 stars rating. Very Good. 1708 reviews4.05 stars rating. Very Good. 1708 reviews
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Strikethrough Rate:~~$116~~Discounted rate:$108USD/night
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Comfort Inn Edwardsville - St. Louis
3080 S. SR 157,
Edwardsville, IL, 62025, US
41.37 km from St Charles, MO, USA
4.17 stars rating. Very Good. 1357 reviews4.17 stars rating. Very Good. 1357 reviews
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Strikethrough Rate:~~$126~~Discounted rate:$113USD/night
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Country Inn & Suites by Radisson, St. Charles Historic District
1190 South Main Street,
Saint Charles, MO, 63301, US
1.28 km from St Charles, MO, USA
4.65 stars rating. Exceptional. 544 reviews4.65 stars rating. Exceptional. 544 reviews
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Hollywood Casino St Louis
777 Casino Center Drive,
Maryland Heights, MO, 63043, US
3.27 km from St Charles, MO, USA
No Reviews YetNo Reviews Yet
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Country Inn & Suites by Radisson, St. Peters, MO
3877 Veterans Memorial Pkwy,
Saint Peters, MO, 63376, US
7.13 km from St Charles, MO, USA
4.12 stars rating. Very Good. 203 reviews4.12 stars rating. Very Good. 203 reviews
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Quality Inn Florissant-St. Louis
55 Dunn Road,
Florissant, MO, 63031, US
12.64 km from St Charles, MO, USA
3.42 stars rating. Good. 1440 reviews3.42 stars rating. Good. 1440 reviews
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Comfort Inn St. Louis Airport
11225 Lone Eagle Dr., Building A,
Bridgeton, MO, 63044, US
8.6 km from St Charles, MO, USA
4.09 stars rating. Very Good. 173 reviews4.09 stars rating. Very Good. 173 reviews
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MainStay Suites St. Louis Airport
11225 Lone Eagle Dr., Building B,
Bridgeton, MO, 63044, US
8.58 km from St Charles, MO, USA
3.93 stars rating. Good. 234 reviews3.93 stars rating. Good. 234 reviews
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Comfort Suites St. Louis - Sunset Hills
3654 S. Lindbergh Blvd.,
Saint Louis, MO, 63127, US
26.48 km from St Charles, MO, USA
4.71 stars rating. Exceptional. 1815 reviews4.71 stars rating. Exceptional. 1815 reviews
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River City Casino & Hotel
777 River City Casino Boulevard,
Saint Louis, MO, 63125, US
33.79 km from St Charles, MO, USA
No Reviews YetNo Reviews Yet
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Radisson Hotel St. Louis Downtown Convention Center
811 N 9th St,
St. Louis, MO, 63101, US
30.14 km from St Charles, MO, USA
No Reviews YetNo Reviews Yet
Coming soonStart booking 29 Oct 2026
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Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive,
O Fallon, MO, 63368, US
20.84 km from St Charles, MO, USA
4.23 stars rating. Excellent. 1212 reviews4.23 stars rating. Excellent. 1212 reviews
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MainStay Suites St. Louis - Galleria
8011 Galleria Pkwy,
St. Louis, MO, 63117, US
20.5 km from St Charles, MO, USA
3.21 stars rating. Good. 163 reviews3.21 stars rating. Good. 163 reviews
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Country Inn & Suites by Radisson, Fairview Heights, IL
140 Ludwig Drive,
Fairview Heights, IL, 62208, US
46.89 km from St Charles, MO, USA
3.2 stars rating. Good. 215 reviews3.2 stars rating. Good. 215 reviews
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Econo Lodge Inn & Suites
3236 W. Chain of Rocks Road,
Granite City, IL, 62040, US
31.29 km from St Charles, MO, USA
3.44 stars rating. Good. 371 reviews3.44 stars rating. Good. 371 reviews
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The Great Rivers, an Ascend Collection Hotel
3559 College Avenue,
Alton, IL, 62002, US
33.19 km from St Charles, MO, USA
2.86 stars rating. Fair. 86 reviews2.86 stars rating. Fair. 86 reviews
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Radisson Hotel Fairview Heights - St. Louis
319 Fountains Pkwy,
Fairview Heights, IL, 62208, US
47.64 km from St Charles, MO, USA
3.1 stars rating. Good. 126 reviews3.1 stars rating. Good. 126 reviews
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Econo Lodge Inn & Suites Fairview Heights - St. Louis
305 Salem Place,
Fairview Heights, IL, 62208, US
47.66 km from St Charles, MO, USA
3.73 stars rating. Good. 315 reviews3.73 stars rating. Good. 315 reviews
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Good to know

Number of hotels

33 hotels in Saint Charles

Highest Price

$121

Lowest Price

$71

Avg. rating

3.4 (33599 reviews)