Book Mainstay Hotels in Florence, SC

Comfort Suites Florence I-95
2120 West Lucas Street,
Florence, SC, 29501, US
3.32 mi from Florence, SC
4.26 stars rating. Excellent. 2613 reviews4.26 stars rating. Excellent. 2613 reviews
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Strikethrough Rate:~~$117~~Discounted rate:$111USD/night
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Clarion Inn & Suites
1819 West Lucas Street, Building A,
Florence, SC, 29501, US
2.75 mi from Florence, SC
1.93 stars rating. Fair. 194 reviews1.93 stars rating. Fair. 194 reviews
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Strikethrough Rate:~~$69~~Discounted rate:$65USD/night
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Suburban Studios Florence - Darlington
1914 West Lucas Street, I-95 & US 52,
Florence, SC, 29501, US
2.84 mi from Florence, SC
2.92 stars rating. Fair. 1323 reviews2.92 stars rating. Fair. 1323 reviews
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Strikethrough Rate:~~$55~~Discounted rate:$51USD/night
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Comfort Inn & Suites
527 Woody Jones Blvd.,
Florence, SC, 29501, US
3.9 mi from Florence, SC
4.5 stars rating. Excellent. 1172 reviews4.5 stars rating. Excellent. 1172 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$113USD/night
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Sleep Inn Florence North
1833 Florence Park Dr., I-95 & US 52,
Florence, SC, 29501, US
3.31 mi from Florence, SC
3.74 stars rating. Good. 1974 reviews3.74 stars rating. Good. 1974 reviews
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Strikethrough Rate:~~$80~~Discounted rate:$74USD/night
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Quality Inn & Suites Florence Civic Center
150 Dunbarton Drive,
Florence, SC, 29501, US
4.24 mi from Florence, SC
3.95 stars rating. Good. 1742 reviews3.95 stars rating. Good. 1742 reviews
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Strikethrough Rate:~~$99~~Discounted rate:$92USD/night
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Econo Lodge
1920 West Lucas Street,
Florence, SC, 29501, US
2.86 mi from Florence, SC
2.87 stars rating. Fair. 1357 reviews2.87 stars rating. Fair. 1357 reviews
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Strikethrough Rate:~~$63~~Discounted rate:$56USD/night
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MainStay Suites
1819 West Lucas Street, Building B,
Florence, SC, 29501, US
2.79 mi from Florence, SC
1.95 stars rating. Fair. 57 reviews1.95 stars rating. Fair. 57 reviews
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Strikethrough Rate:~~$72~~Discounted rate:$67USD/night
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Park Inn by Radisson Florence, SC
1729 Mandeville Road,
Florence, SC, 29501, US
3.06 mi from Florence, SC
4.27 stars rating. Excellent. 344 reviews4.27 stars rating. Excellent. 344 reviews
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Strikethrough Rate:~~$111~~Discounted rate:$105USD/night
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Quality Inn
903 South Fifth Street,
Hartsville, SC, 29550, US
20.62 mi from Florence, SC
2.96 stars rating. Fair. 395 reviews2.96 stars rating. Fair. 395 reviews
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Strikethrough Rate:~~$75~~Discounted rate:$70USD/night
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Quality Inn & Suites
202 North Ron McNair Blvd.,
Lake City, SC, 29560, US
22.06 mi from Florence, SC
3.32 stars rating. Good. 97 reviews3.32 stars rating. Good. 97 reviews
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Strikethrough Rate:~~$136~~Discounted rate:$126USD/night
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Rodeway Inn
415 S. Irby St.,
Florence, SC, 29501, US
0.46 mi from Florence, SC
No Reviews YetNo Reviews Yet
Coming soonStart booking Sep 30, 2025
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Good to know

Number of hotels

12 hotels in Florence

Highest Price

$126

Lowest Price

$51

Avg. rating

11 hotels near Florence, SC

Comfort Suites Florence I-95

Clarion Inn & Suites

Suburban Studios Florence - Darlington

Comfort Inn & Suites

Sleep Inn Florence North

Quality Inn & Suites Florence Civic Center

Econo Lodge

MainStay Suites

Park Inn by Radisson Florence, SC

Quality Inn

Quality Inn & Suites

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Rodeway Inn

Other Florence searches

Good to know

12 hotels in Florence

$126

$51

3.1 (11268 reviews)