Book Top Rated Hotels in Defiance, MO

Comfort Inn & Suites Chesterfield - St. Louis
18375 Chesterfield Arpt. Rd.,
Chesterfield, MO, 63005, US
11.83 km from Defiance, MO, US
3.91 stars rating. Good. 2483 reviews
Book Now & Save 18%
Strikethrough Rate:~~$103~~Discounted rate:$84USD/night
Member Rate
Fees included
See Availability
Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive,
O Fallon, MO, 63368, US
11.25 km from Defiance, MO, US
4.23 stars rating. Excellent. 1258 reviews
Book Now & Save 15%
Strikethrough Rate:~~$119~~Discounted rate:$102USD/night
Member Rate
See Availability
Comfort Inn & Suites St. Louis-O'Fallon
8170 Veterans Memorial Pkwy,
O Fallon, MO, 63366, US
20.55 km from Defiance, MO, US
3.68 stars rating. Good. 1907 reviews
Book Now & Save 3%
Strikethrough Rate:~~$89~~Discounted rate:$86USD/night
Member Rate
See Availability
Quality Inn Pacific near Six Flags St. Louis
1400 West Osage St.,
Pacific, MO, 63069, US
16.61 km from Defiance, MO, US
4 stars rating. Very Good. 657 reviews
Book Now & Save 10%
Strikethrough Rate:~~$94~~Discounted rate:$85USD/night
Member Rate
See Availability
Comfort Inn Near Six Flags St. Louis
1320 Thornton St.,
Pacific, MO, 63069, US
16.41 km from Defiance, MO, US
4.06 stars rating. Very Good. 1766 reviews
Book Now & Save 5%
Strikethrough Rate:~~$114~~Discounted rate:$109USD/night
Member Rate
See Availability
Quality Inn Foristell
12 Highway W,
Foristell, MO, 63348, US
25.61 km from Defiance, MO, US
4.21 stars rating. Excellent. 926 reviews
Book Now & Save 19%
Strikethrough Rate:~~$127~~Discounted rate:$103USD/night
Member Rate
See Availability
Country Inn & Suites by Radisson, St. Peters, MO
3877 Veterans Memorial Pkwy,
Saint Peters, MO, 63376, US
25.76 km from Defiance, MO, US
4.07 stars rating. Very Good. 225 reviews
Book Now & Save 5%
Strikethrough Rate:~~$134~~Discounted rate:$127USD/night
Member Rate
See Availability
AWARD WINNER
Comfort Suites St. Louis - Sunset Hills
3654 S. Lindbergh Blvd.,
Saint Louis, MO, 63127, US
33.56 km from Defiance, MO, US
4.72 stars rating. Exceptional. 1954 reviews
Book Now & Save 5%
Strikethrough Rate:~~$134~~Discounted rate:$127USD/night
Member Rate
See Availability
Comfort Inn & Suites Hazelwood - St. Louis
7133 Douglas Palmer Place,
Hazelwood, MO, 63042, US
40.14 km from Defiance, MO, US
4.11 stars rating. Very Good. 1989 reviews
Book Now & Save 10%
Strikethrough Rate:~~$110~~Discounted rate:$99USD/night
Member Rate
See Availability
Comfort Suites St Charles-St Louis
1400 S. Fifth Street,
Saint Charles, MO, 63301, US
29.13 km from Defiance, MO, US
4.02 stars rating. Very Good. 2079 reviews
Book Now & Save 5%
Strikethrough Rate:~~$129~~Discounted rate:$123USD/night
Member Rate
See Availability
Comfort Inn St. Louis Airport
11225 Lone Eagle Dr., Building A,
Bridgeton, MO, 63044, US
35.11 km from Defiance, MO, US
4.05 stars rating. Very Good. 183 reviews
Book Now & Save 15%
Strikethrough Rate:~~$121~~Discounted rate:$103USD/night
Member Rate
See Availability
Sleep Inn Saint Charles North
150 Fountain Lakes Blvd.,
Saint Charles, MO, 63301, US
31.12 km from Defiance, MO, US
3.09 stars rating. Fair. 1040 reviews
Book Now & Save 5%
Strikethrough Rate:~~$94~~Discounted rate:$89USD/night
Member Rate
See Availability
Quality Inn Saint Louis Airport
10232 Natural Bridge Rd.,
Saint Louis, MO, 63134, US
38.28 km from Defiance, MO, US
3.27 stars rating. Good. 3055 reviews
Book Now & Save 5%
Strikethrough Rate:~~$76~~Discounted rate:$72USD/night
Member Rate
See Availability
Quality Inn Florissant-St. Louis
55 Dunn Road,
Florissant, MO, 63031, US
41.6 km from Defiance, MO, US
3.41 stars rating. Good. 1467 reviews
Book Now & Save 5%
Strikethrough Rate:~~$77~~Discounted rate:$74USD/night
Member Rate
See Availability
MainStay Suites St. Louis Airport
11225 Lone Eagle Dr., Building B,
Bridgeton, MO, 63044, US
35.12 km from Defiance, MO, US
3.91 stars rating. Good. 240 reviews
Book Now & Save 15%
Strikethrough Rate:~~$116~~Discounted rate:$99USD/night
Member Rate
See Availability
MainStay Suites St. Louis - Galleria
8011 Galleria Pkwy,
St. Louis, MO, 63117, US
37.77 km from Defiance, MO, US
3.2 stars rating. Good. 193 reviews
Book Now & Save 5%
Strikethrough Rate:~~$129~~Discounted rate:$123USD/night
Member Rate
See Availability
River City Casino & Hotel
777 River City Casino Boulevard,
Saint Louis, MO, 63125, US
46.14 km from Defiance, MO, US
No Reviews Yet
$285USD/night
Fees included
See Availability
Hollywood Casino St Louis
777 Casino Center Drive,
Maryland Heights, MO, 63043, US
29.04 km from Defiance, MO, US
No Reviews Yet
$355USD/night
Fees included
See Availability

Change your dates to book properties below.

Comfort Inn St. Louis - Westport Event Center
12031 Lackland Rd.,
Saint Louis, MO, 63146, US
29.95 km from Defiance, MO, US
3.55 stars rating. Good. 3113 reviews
Sold outfor your selected dates
See Availability
AWARD WINNER
Country Inn & Suites by Radisson, St. Charles Historic District
1190 South Main Street,
Saint Charles, MO, 63301, US
29.78 km from Defiance, MO, US
4.65 stars rating. Exceptional. 649 reviews
Sold outfor your selected dates
See Availability

Good to know

Top-Rated hotels

20 hotels in Defiance

Highest Price

$355

Lowest Price

$72

Avg. rating

18 Top Rated hotels near Defiance, MO, US

Comfort Inn & Suites Chesterfield - St. Louis

Sleep Inn & Suites O'Fallon MO - Technology Drive

Comfort Inn & Suites St. Louis-O'Fallon

Quality Inn Pacific near Six Flags St. Louis

Comfort Inn Near Six Flags St. Louis

Quality Inn Foristell

Country Inn & Suites by Radisson, St. Peters, MO

Comfort Suites St. Louis - Sunset Hills

Comfort Inn & Suites Hazelwood - St. Louis

Comfort Suites St Charles-St Louis

Comfort Inn St. Louis Airport

Sleep Inn Saint Charles North

Quality Inn Saint Louis Airport

Quality Inn Florissant-St. Louis

MainStay Suites St. Louis Airport

MainStay Suites St. Louis - Galleria

River City Casino & Hotel

Hollywood Casino St Louis

Change your dates to book properties below.

Comfort Inn St. Louis - Westport Event Center

Country Inn & Suites by Radisson, St. Charles Historic District

Other Defiance searches

Good to know

20 hotels in Defiance

$355

$72

3.5 (25184 reviews)