Book Boutique Hotels in Odessa, TX | Choice Hotels

Comfort Inn & Suites, Odessa I-20
801 South JBS Parkway,
Odessa, TX, 79761, US
4.9 km from Odessa, TX, USA
3.79 stars rating. Good. 662 reviews3.79 stars rating. Good. 662 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$116USD/night
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MainStay Suites Odessa I-20
1801 S. Highway 385,
Odessa, TX, 79766, US
2.49 km from Odessa, TX, USA
4.43 stars rating. Excellent. 214 reviews4.43 stars rating. Excellent. 214 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$125USD/night
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Sleep Inn & Suites Odessa near University
3101 East Business 20,
Odessa, TX, 79761, US
5.6 km from Odessa, TX, USA
3.96 stars rating. Good. 365 reviews3.96 stars rating. Good. 365 reviews
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Strikethrough Rate:~~$125~~Discounted rate:$113USD/night
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Comfort Suites Odessa near University
4801 East 50th Street,
Odessa, TX, 79762, US
6.7 km from Odessa, TX, USA
3.88 stars rating. Good. 678 reviews3.88 stars rating. Good. 678 reviews
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Strikethrough Rate:~~$160~~Discounted rate:$136USD/night
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AWARD WINNER
Suburban Studios Midland I-20
3001 Antelope Trail,
Midland, TX, 79706, US
24.17 km from Odessa, TX, USA
4.41 stars rating. Excellent. 193 reviews4.41 stars rating. Excellent. 193 reviews
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Strikethrough Rate:~~$203~~Discounted rate:$193USD/night
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AWARD WINNER
Sleep Inn & Suites Midland West
5612 Deauville Blvd,
Midland, TX, 79706, US
25.72 km from Odessa, TX, USA
4.41 stars rating. Excellent. 705 reviews4.41 stars rating. Excellent. 705 reviews
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Strikethrough Rate:~~$189~~Discounted rate:$170USD/night
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Rodeway Inn Midland South
1000 S Midkiff Rd,
Midland, TX, 79701-7132, US
28.27 km from Odessa, TX, USA
1.35 stars rating. Fair. 17 reviews1.35 stars rating. Fair. 17 reviews
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Strikethrough Rate:~~$65~~Discounted rate:$57USD/night
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Quality Inn Midland South
902 Interstate 20 West,
Midland, TX, 79701, US
30.91 km from Odessa, TX, USA
3.89 stars rating. Good. 598 reviews3.89 stars rating. Good. 598 reviews
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Strikethrough Rate:~~$120~~Discounted rate:$112USD/night
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Comfort Suites Midland West
5606 Westridge Blvd,
Midland, TX, 79706, US
25.96 km from Odessa, TX, USA
4.26 stars rating. Excellent. 401 reviews4.26 stars rating. Excellent. 401 reviews
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Strikethrough Rate:~~$219~~Discounted rate:$197USD/night
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Comfort Inn Midland South I-20
910 West I-20,
Midland, TX, 79701, US
30.74 km from Odessa, TX, USA
3.69 stars rating. Good. 594 reviews3.69 stars rating. Good. 594 reviews
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Strikethrough Rate:~~$159~~Discounted rate:$143USD/night
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Quality Suites Midland North Loop 250
4706 North Garfield Street,
Midland, TX, 79705, US
32.34 km from Odessa, TX, USA
3.99 stars rating. Good. 643 reviews3.99 stars rating. Good. 643 reviews
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Strikethrough Rate:~~$169~~Discounted rate:$152USD/night
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MainStay Suites Midland
2500 South Lamesa Road,
Midland, TX, 79701, US
32.66 km from Odessa, TX, USA
3.7 stars rating. Good. 189 reviews3.7 stars rating. Good. 189 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$120USD/night
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NEW TO CHOICE
Quality Inn
3071 E Business 20,
Odessa, TX, 79761, US
5.42 km from Odessa, TX, USA
No Reviews YetNo Reviews Yet
Coming soonStart booking Feb 02, 2026
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Good to know

Boutique hotels

13 hotels in Odessa

Highest Price

$197

Lowest Price

$57

Avg. rating

3.5 (5259 reviews)