Book Boutique Hotels in La Mesa, CA

Comfort Inn Gaslamp Convention Center
660 G Street,
San Diego, CA, 92101, US
14.08 km from La Mesa, CA, USA
3.91 stars rating. Good. 2272 reviews3.91 stars rating. Good. 2272 reviews
BOOK NOW AND SAVE 16%
Strikethrough Rate:~~$114~~Discounted rate:$95USD/night
Member Rate
See Availability
Comfort Inn Chula Vista San Diego South
91 E. Bonita Road,
Chula Vista, CA, 91910, US
13.81 km from La Mesa, CA, USA
3.86 stars rating. Good. 1847 reviews3.86 stars rating. Good. 1847 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$124~~Discounted rate:$112USD/night
Member Rate
See Availability
Comfort Inn San Diego Airport At the Harbor
5102 N. Harbor Drive,
San Diego, CA, 92106, US
19.68 km from La Mesa, CA, USA
3.94 stars rating. Good. 2115 reviews3.94 stars rating. Good. 2115 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$105~~Discounted rate:$98USD/night
Member Rate
See Availability
Rodeway Inn San Diego Near SDSU
5399 Adobe Falls Road,
San Diego, CA, 92120, US
5.81 km from La Mesa, CA, USA
3.45 stars rating. Good. 1115 reviews3.45 stars rating. Good. 1115 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$69~~Discounted rate:$64USD/night
Member Rate
See Availability
Quality Inn San Diego I-5 Naval Base
3878 Dalbergia Court,
San Diego, CA, 92113, US
12.49 km from La Mesa, CA, USA
3.81 stars rating. Good. 718 reviews3.81 stars rating. Good. 718 reviews
BOOK NOW AND SAVE 19%
Strikethrough Rate:~~$109~~Discounted rate:$88USD/night
Member Rate
See Availability
Rodeway Inn Lemon Grove San Diego East
7458 Broadway,
Lemon Grove, CA, 91945, US
3.08 km from La Mesa, CA, USA
2.6 stars rating. Fair. 81 reviews2.6 stars rating. Fair. 81 reviews
BOOK NOW AND SAVE 16%
Strikethrough Rate:~~$89~~Discounted rate:$74USD/night
Member Rate
See Availability
Carlton Oaks Lodge, an Ascend Collection Hotel
9200 Inwood Drive,
Santee, CA, 92071, US
8.49 km from La Mesa, CA, USA
3.25 stars rating. Good. 402 reviews3.25 stars rating. Good. 402 reviews
BOOK NOW AND SAVE 13%
Strikethrough Rate:~~$129~~Discounted rate:$112USD/night
Special Rate
Fees included
See Availability
Comfort Inn San Diego Miramar
9350 Kearny Mesa Road,
San Diego, CA, 92126, US
16.55 km from La Mesa, CA, USA
3.37 stars rating. Good. 1002 reviews3.37 stars rating. Good. 1002 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$92~~Discounted rate:$86USD/night
Member Rate
See Availability
Comfort Inn San Diego Old Town
2380 Moore Street,
San Diego, CA, 92110, US
16.17 km from La Mesa, CA, USA
3.62 stars rating. Good. 680 reviews3.62 stars rating. Good. 680 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$110~~Discounted rate:$99USD/night
Member Rate
See Availability
Rodeway Inn Santee San Diego East
10135 Mission Gorge Road,
Santee, CA, 92071-3813, US
8.97 km from La Mesa, CA, USA
3.63 stars rating. Good. 526 reviews3.63 stars rating. Good. 526 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$89~~Discounted rate:$80USD/night
Member Rate
Fees included
See Availability
Clarion Pointe El Cajon San Diego East
855 Sandalwood Dr,
El Cajon, CA, 92021, US
7.79 km from La Mesa, CA, USA
2.5 stars rating. Fair. 117 reviews2.5 stars rating. Fair. 117 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$95~~Discounted rate:$91USD/night
Member Rate
See Availability
Quality Inn & Suites El Cajon San Diego East
650 N Mollison Ave, Building A,
El Cajon, CA, 92021, US
7.81 km from La Mesa, CA, USA
2.16 stars rating. Fair. 251 reviews2.16 stars rating. Fair. 251 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$89~~Discounted rate:$83USD/night
Member Rate
See Availability
Comfort Inn Sea World Area
3880 Greenwood St.,
San Diego, CA, 92110, US
17.14 km from La Mesa, CA, USA
4.01 stars rating. Very Good. 537 reviews4.01 stars rating. Very Good. 537 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$105~~Discounted rate:$98USD/night
Member Rate
See Availability
Quality Inn San Diego South - Chula Vista
778 Broadway,
Chula Vista, CA, 91910-5329, US
17.33 km from La Mesa, CA, USA
3.94 stars rating. Good. 86 reviews3.94 stars rating. Good. 86 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$84~~Discounted rate:$76USD/night
Member Rate
See Availability
Rodeway Inn El Cajon - San Diego East
1368 East Main Street,
El Cajon, CA, 92021, US
9.18 km from La Mesa, CA, USA
2.89 stars rating. Fair. 18 reviews2.89 stars rating. Fair. 18 reviews
BOOK NOW AND SAVE 16%
Strikethrough Rate:~~$78~~Discounted rate:$66USD/night
Member Rate
See Availability
Rodeway Inn National City San Diego South
607 Roosevelt Ave,
National City, CA, 91950, US
12.86 km from La Mesa, CA, USA
3.12 stars rating. Good. 57 reviews3.12 stars rating. Good. 57 reviews
BOOK NOW AND SAVE 19%
Strikethrough Rate:~~$79~~Discounted rate:$64USD/night
Member Rate
See Availability
Country Inn & Suites by Radisson, San Diego North, CA
5975 Lusk Boulevard,
San Diego, CA, 92121, US
21.48 km from La Mesa, CA, USA
4.28 stars rating. Excellent. 383 reviews4.28 stars rating. Excellent. 383 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$177~~Discounted rate:$159USD/night
Member Rate
See Availability
Quality Suites San Diego Otay Mesa
2351 Otay Center Drive,
San Diego, CA, 92154-7614, US
24.71 km from La Mesa, CA, USA
3.47 stars rating. Good. 500 reviews3.47 stars rating. Good. 500 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$105~~Discounted rate:$98USD/night
Member Rate
See Availability
AWARD WINNER
Rodeway Inn Encinitas North
1444 N. Coast Hwy 101,
Encinitas, CA, 92024, US
42.97 km from La Mesa, CA, USA
3.86 stars rating. Good. 898 reviews3.86 stars rating. Good. 898 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$70~~Discounted rate:$67USD/night
Member Rate
Fees included
See Availability
Comfort Inn Escondido San Diego North County
1290 West Valley Parkway,
Escondido, CA, 92029, US
39.28 km from La Mesa, CA, USA
4.05 stars rating. Very Good. 1486 reviews4.05 stars rating. Very Good. 1486 reviews
$136USD/night
See Availability
Quality Inn Escondido San Diego North County
501 W Mission Ave,
Escondido, CA, 92025, US
40.51 km from La Mesa, CA, USA
3.35 stars rating. Good. 284 reviews3.35 stars rating. Good. 284 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$90~~Discounted rate:$84USD/night
Member Rate
See Availability
Econo Lodge Inn & Suites Escondido Downtown
515 W Washington Avenue,
Escondido, CA, 92025, US
40.09 km from La Mesa, CA, USA
3.62 stars rating. Good. 615 reviews3.62 stars rating. Good. 615 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$74~~Discounted rate:$69USD/night
Member Rate
See Availability
Rodeway Inn Escondido Downtown
250 W. El Norte Pkwy,
Escondido, CA, 92026, US
41.86 km from La Mesa, CA, USA
3.21 stars rating. Good. 256 reviews3.21 stars rating. Good. 256 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$79~~Discounted rate:$73USD/night
Member Rate
See Availability
Comfort Inn Encinitas Near Legoland
607 Leucadia Blvd,
Encinitas, CA, 92024, US
41.44 km from La Mesa, CA, USA
3.2 stars rating. Good. 1225 reviews3.2 stars rating. Good. 1225 reviews
BOOK NOW AND SAVE 16%
Strikethrough Rate:~~$95~~Discounted rate:$80USD/night
Member Rate
See Availability
Sleep Inn Tijuana
Blvd. M. Clouthier No. 16651, Rio Tijuana,
Tijuana, BCN, 22226, MX
31.74 km from La Mesa, CA, USA
3.83 stars rating. Good. 636 reviews3.83 stars rating. Good. 636 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$1,705~~Discounted rate:$1,535MXN/night
Member Rate
See Availability

Change your dates to book properties below.

NEW TO CHOICE
Comfort Suites Tijuana
Av. C Niños Héroes 1584, Zona Centro,
Tijuana, BCN, 22000, MX
26.64 km from La Mesa, CA, USA
No Reviews YetNo Reviews Yet
Coming soonStart booking Feb 24, 2026
See Availability

Good to know

Boutique hotels

26 hotels in La Mesa

Highest Price

$1,535

Lowest Price

$64

Avg. rating

25 Boutique hotels near La Mesa, CA, USA

Comfort Inn Gaslamp Convention Center

Comfort Inn Chula Vista San Diego South

Comfort Inn San Diego Airport At the Harbor

Rodeway Inn San Diego Near SDSU

Quality Inn San Diego I-5 Naval Base

Rodeway Inn Lemon Grove San Diego East

Carlton Oaks Lodge, an Ascend Collection Hotel

Comfort Inn San Diego Miramar

Comfort Inn San Diego Old Town

Rodeway Inn Santee San Diego East

Clarion Pointe El Cajon San Diego East

Quality Inn & Suites El Cajon San Diego East

Comfort Inn Sea World Area

Quality Inn San Diego South - Chula Vista

Rodeway Inn El Cajon - San Diego East

Rodeway Inn National City San Diego South

Country Inn & Suites by Radisson, San Diego North, CA

Quality Suites San Diego Otay Mesa

Rodeway Inn Encinitas North

Comfort Inn Escondido San Diego North County

Quality Inn Escondido San Diego North County

Econo Lodge Inn & Suites Escondido Downtown

Rodeway Inn Escondido Downtown

Comfort Inn Encinitas Near Legoland

Sleep Inn Tijuana

Change your dates to book properties below.

Comfort Suites Tijuana

Other La Mesa searches

Good to know

26 hotels in La Mesa

$1,535

$64

3.3 (18107 reviews)