Extended Stay Hotels in Clayton, MO - Choice Hotels

MainStay Suites St. Louis - Galleria
8011 Galleria Pkwy,
St. Louis, MO, 63117, US
1.92 km from Clayton, MO, USA
3.23 stars rating. Good. 165 reviews3.23 stars rating. Good. 165 reviews
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Strikethrough Rate:~~$115~~Discounted rate:$80USD/night
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MainStay Suites St. Louis Airport
11225 Lone Eagle Dr., Building B,
Bridgeton, MO, 63044, US
11.47 km from Clayton, MO, USA
3.93 stars rating. Good. 234 reviews3.93 stars rating. Good. 234 reviews
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Strikethrough Rate:~~$121~~Discounted rate:$85USD/night
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Below are additional hotels in the area that do not match your exact search criteria.

Comfort Inn St. Louis - Westport Event Center
12031 Lackland Rd.,
Saint Louis, MO, 63146, US
10.72 km from Clayton, MO, USA
3.57 stars rating. Good. 3077 reviews3.57 stars rating. Good. 3077 reviews
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Strikethrough Rate:~~$101~~Discounted rate:$75USD/night
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Comfort Inn St. Louis Airport
11225 Lone Eagle Dr., Building A,
Bridgeton, MO, 63044, US
11.43 km from Clayton, MO, USA
4.07 stars rating. Very Good. 176 reviews4.07 stars rating. Very Good. 176 reviews
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Strikethrough Rate:~~$110~~Discounted rate:$83USD/night
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Stay Longer. Save More.
Say hello to WoodSpring Suites® hotels! Designed for longer stays, we offer contemporary suites with in-room kitchens and free WiFi. Plus, our affordable rates cost less per night when you stay a week, month or more.
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Quality Inn Airport
10232 Natural Bridge Rd.,
Saint Louis, MO, 63134, US
9.69 km from Clayton, MO, USA
3.27 stars rating. Good. 3022 reviews3.27 stars rating. Good. 3022 reviews
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Strikethrough Rate:~~$77~~Discounted rate:$72USD/night
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Quality Inn Florissant-St. Louis
55 Dunn Road,
Florissant, MO, 63031, US
14.02 km from Clayton, MO, USA
3.41 stars rating. Good. 1447 reviews3.41 stars rating. Good. 1447 reviews
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Strikethrough Rate:~~$76~~Discounted rate:$72USD/night
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Quality Inn & Suites near St. Louis and I-255
1607 Pontiac Drive,
Cahokia, IL, 62206, US
18.3 km from Clayton, MO, USA
3.54 stars rating. Good. 1344 reviews3.54 stars rating. Good. 1344 reviews
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Strikethrough Rate:~~$84~~Discounted rate:$63USD/night
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Comfort Suites St. Louis - Sunset Hills
3654 S. Lindbergh Blvd.,
Saint Louis, MO, 63127, US
12.37 km from Clayton, MO, USA
4.71 stars rating. Exceptional. 1829 reviews4.71 stars rating. Exceptional. 1829 reviews
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Strikethrough Rate:~~$120~~Discounted rate:$112USD/night
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Comfort Inn & Suites St. Louis-Hazelwood
7133 Douglas Palmer Place,
Hazelwood, MO, 63042, US
14.48 km from Clayton, MO, USA
4.12 stars rating. Very Good. 1975 reviews4.12 stars rating. Very Good. 1975 reviews
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Strikethrough Rate:~~$102~~Discounted rate:$86USD/night
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Comfort Inn & Suites
2625 Lafayette Ave,
Saint Louis, MO, 63104-2011, US
10.69 km from Clayton, MO, USA
3.82 stars rating. Good. 92 reviews3.82 stars rating. Good. 92 reviews
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Strikethrough Rate:~~$123~~Discounted rate:$115USD/night
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Comfort Suites St Charles-St Louis
1400 S. Fifth Street,
Saint Charles, MO, 63301, US
18.85 km from Clayton, MO, USA
4.03 stars rating. Very Good. 2063 reviews4.03 stars rating. Very Good. 2063 reviews
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Strikethrough Rate:~~$116~~Discounted rate:$93USD/night
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Hollywood Casino St Louis
777 Casino Center Drive,
Maryland Heights, MO, 63043, US
17.1 km from Clayton, MO, USA
No Reviews YetNo Reviews Yet
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Strikethrough Rate:~~$149~~Discounted rate:$129USD/night
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Country Inn & Suites by Radisson, St. Charles Historic District
1190 South Main Street,
Saint Charles, MO, 63301, US
18.75 km from Clayton, MO, USA
4.65 stars rating. Exceptional. 565 reviews4.65 stars rating. Exceptional. 565 reviews
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Strikethrough Rate:~~$167~~Discounted rate:$157USD/night
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Comfort Inn & Suites Chesterfield - St. Louis
18375 Chesterfield Arpt. Rd.,
Chesterfield, MO, 63005, US
27.48 km from Clayton, MO, USA
3.92 stars rating. Good. 2441 reviews3.92 stars rating. Good. 2441 reviews
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Strikethrough Rate:~~$118~~Discounted rate:$86USD/night
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Quality Inn & Suites Caseyville - St. Louis
2180 Patricia Dr.,
Caseyville, IL, 62232, US
25.59 km from Clayton, MO, USA
2.73 stars rating. Fair. 705 reviews2.73 stars rating. Fair. 705 reviews
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Strikethrough Rate:~~$76~~Discounted rate:$57USD/night
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Econo Lodge Inn & Suites
3236 W. Chain of Rocks Road,
Granite City, IL, 62040, US
22.47 km from Clayton, MO, USA
3.43 stars rating. Good. 373 reviews3.43 stars rating. Good. 373 reviews
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Strikethrough Rate:~~$73~~Discounted rate:$68USD/night
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Comfort Inn Collinsville near St. Louis
8 Commerce Dr.,
Collinsville, IL, 62234, US
28.34 km from Clayton, MO, USA
4.19 stars rating. Very Good. 1915 reviews4.19 stars rating. Very Good. 1915 reviews
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Strikethrough Rate:~~$118~~Discounted rate:$85USD/night
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Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive,
O Fallon, MO, 63368, US
32.92 km from Clayton, MO, USA
4.23 stars rating. Excellent. 1217 reviews4.23 stars rating. Excellent. 1217 reviews
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Strikethrough Rate:~~$99~~Discounted rate:$75USD/night
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Country Inn & Suites by Radisson, St. Peters, MO
3877 Veterans Memorial Pkwy,
Saint Peters, MO, 63376, US
25.19 km from Clayton, MO, USA
4.12 stars rating. Very Good. 207 reviews4.12 stars rating. Very Good. 207 reviews
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Strikethrough Rate:~~$108~~Discounted rate:$101USD/night
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Sleep Inn
150 Fountain Lakes Blvd.,
Saint Charles, MO, 63301, US
25.22 km from Clayton, MO, USA
3.08 stars rating. 1020 reviews3.08 stars rating. 1020 reviews
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Strikethrough Rate:~~$85~~Discounted rate:$80USD/night
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Country Inn & Suites by Radisson, Fairview Heights, IL
140 Ludwig Drive,
Fairview Heights, IL, 62208, US
30.29 km from Clayton, MO, USA
3.19 stars rating. Good. 218 reviews3.19 stars rating. Good. 218 reviews
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Strikethrough Rate:~~$102~~Discounted rate:$69USD/night
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Quality Inn O'Fallon IL - St. Louis
1409 W US 50,
O Fallon, IL, 62269, US
34.01 km from Clayton, MO, USA
3.56 stars rating. Good. 922 reviews3.56 stars rating. Good. 922 reviews
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Strikethrough Rate:~~$69~~Discounted rate:$59USD/night
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Sleep Inn O'Fallon near I-64
140 Venita Drive,
O Fallon, IL, 62269, US
35.19 km from Clayton, MO, USA
3.39 stars rating. Good. 1322 reviews3.39 stars rating. Good. 1322 reviews
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Strikethrough Rate:~~$65~~Discounted rate:$58USD/night
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Comfort Suites Fairview Heights - St Louis
137 Ludwig Drive,
Fairview Heights, IL, 62208, US
30.27 km from Clayton, MO, USA
3.46 stars rating. Good. 1775 reviews3.46 stars rating. Good. 1775 reviews
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Strikethrough Rate:~~$100~~Discounted rate:$75USD/night
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Comfort Inn Alton near I-255
11 Crossroads Ct.,
Alton, IL, 62002, US
33.28 km from Clayton, MO, USA
3.66 stars rating. Good. 854 reviews3.66 stars rating. Good. 854 reviews
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Strikethrough Rate:~~$94~~Discounted rate:$72USD/night
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Comfort Inn Edwardsville - St. Louis
3080 S. SR 157,
Edwardsville, IL, 62025, US
31.54 km from Clayton, MO, USA
4.17 stars rating. Very Good. 1364 reviews4.17 stars rating. Very Good. 1364 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$116USD/night
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Econo Lodge Inn & Suites Fairview Heights - St. Louis
305 Salem Place,
Fairview Heights, IL, 62208, US
31.16 km from Clayton, MO, USA
3.74 stars rating. Good. 316 reviews3.74 stars rating. Good. 316 reviews
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Strikethrough Rate:~~$78~~Discounted rate:$73USD/night
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Comfort Inn & Suites St. Louis-O'Fallon
100 Comfort Inn Court,
O Fallon, MO, 63366, US
34.05 km from Clayton, MO, USA
3.68 stars rating. Good. 1862 reviews3.68 stars rating. Good. 1862 reviews
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Strikethrough Rate:~~$91~~Discounted rate:$82USD/night
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The Great Rivers, an Ascend Collection Hotel
3559 College Avenue,
Alton, IL, 62002, US
33.4 km from Clayton, MO, USA
2.81 stars rating. Fair. 91 reviews2.81 stars rating. Fair. 91 reviews
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Strikethrough Rate:~~$118~~Discounted rate:$112USD/night
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Radisson Hotel Fairview Heights - St. Louis
319 Fountains Pkwy,
Fairview Heights, IL, 62208, US
31.21 km from Clayton, MO, USA
3.12 stars rating. Good. 131 reviews3.12 stars rating. Good. 131 reviews
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Strikethrough Rate:~~$110~~Discounted rate:$99USD/night
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Comfort Inn Near Six Flags St. Louis
1320 Thornton St.,
Pacific, MO, 63069, US
40.77 km from Clayton, MO, USA
4.05 stars rating. Very Good. 1721 reviews4.05 stars rating. Very Good. 1721 reviews
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Strikethrough Rate:~~$127~~Discounted rate:$119USD/night
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Comfort Inn & Suites OFallon - St Louis Area
116 Regency Park,
O'Fallon, IL, 62269, US
35.18 km from Clayton, MO, USA
2.33 stars rating. Fair. 99 reviews2.33 stars rating. Fair. 99 reviews
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Strikethrough Rate:~~$93~~Discounted rate:$67USD/night
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Quality Inn Near Six Flags St. Louis
1400 West Osage St.,
Pacific, MO, 63069, US
40.91 km from Clayton, MO, USA
4 stars rating. Very Good. 653 reviews4 stars rating. Very Good. 653 reviews
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Strikethrough Rate:~~$114~~Discounted rate:$103USD/night
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Change your dates to book properties below.

Radisson Hotel St. Louis Downtown Convention Center
811 N 9th St,
St. Louis, MO, 63101, US
12.71 km from Clayton, MO, USA
No Reviews YetNo Reviews Yet
Coming soonStart booking Nov 12, 2025
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River City Casino & Hotel
777 River City Casino Boulevard,
Saint Louis, MO, 63125, US
14.64 km from Clayton, MO, USA
No Reviews YetNo Reviews Yet
Sold outfor your selected dates
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Good to know

Extended stay hotels

2 of 35 hotels in Clayton

Highest Price

$157

Lowest Price

$57

Avg. rating

3.3 (35195 reviews)

Weekly Rate

$399

Monthly Rate

$1,710