34 hotels near Clayton, MO, USA

34 hotels near Clayton, MO, USA

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    • 40

      Comfort Inn St. Louis - Westport Event Center

      6.66 mi from destination

      3.57 stars rating. Good. 3071 reviews
      Save 12%
      Strikethrough Rate:$99Discounted rate:$87USD/night
      Member Rate
    • 30

      Comfort Inn St. Louis Airport

      7.1 mi from destination

      4.07 stars rating. Very Good. 175 reviews
      Save 16%
      Strikethrough Rate:$103Discounted rate:$86USD/night
      Member Rate
    • 32

      Comfort Inn & Suites St. Louis-Hazelwood

      9 mi from destination

      4.12 stars rating. Very Good. 1974 reviews
      Save 12%
      Strikethrough Rate:$94Discounted rate:$83USD/night
      Member Rate
    • 38

      MainStay Suites St. Louis - Galleria

      1.19 mi from destination

      3.23 stars rating. Good. 164 reviews
      Save 16%
      Strikethrough Rate:$139Discounted rate:$116USD/night
      Member Rate
    • 33

      Comfort Suites St. Louis - Sunset Hills

      7.69 mi from destination

      4.71 stars rating. Exceptional. 1824 reviews
      Save 7%
      Strikethrough Rate:$119Discounted rate:$111USD/night
      Member Rate
    • 12

      Quality Inn Florissant-St. Louis

      8.71 mi from destination

      3.42 stars rating. Good. 1442 reviews
      Save 7%
      Strikethrough Rate:$69Discounted rate:$64USD/night
      Member Rate
    • 30

      Quality Inn Airport

      6.02 mi from destination

      3.27 stars rating. Good. 3021 reviews
      Save 7%
      Strikethrough Rate:$82Discounted rate:$76USD/night
      Member Rate
    • 35

      Comfort Inn & Suites

      6.64 mi from destination

      3.8 stars rating. Good. 91 reviews
      Save 7%
      Strikethrough Rate:$119Discounted rate:$111USD/night
      Member Rate
    • 21

      Quality Inn & Suites near St. Louis and I-255

      11.37 mi from destination

      3.54 stars rating. Good. 1344 reviews
      Save 16%
      Strikethrough Rate:$88Discounted rate:$74USD/night
      Member Rate
    • 27

      MainStay Suites St. Louis Airport

      7.12 mi from destination

      3.93 stars rating. Good. 234 reviews
      Save 16%
      Strikethrough Rate:$116Discounted rate:$97USD/night
      Member Rate
    • 35

      Comfort Suites St Charles-St Louis

      11.71 mi from destination

      4.03 stars rating. Very Good. 2060 reviews
      Save 7%
      Strikethrough Rate:$119Discounted rate:$110USD/night
      Member Rate
    • 25

      Country Inn & Suites by Radisson, St. Charles Historic District

      11.65 mi from destination

      4.65 stars rating. Exceptional. 559 reviews
      Save 7%
      Strikethrough Rate:$154Discounted rate:$143USD/night
      Member Rate
    • 38

      Comfort Inn & Suites Chesterfield - St. Louis

      17.07 mi from destination

      3.92 stars rating. Good. 2438 reviews
      Save 14%
      Strikethrough Rate:$114Discounted rate:$98USD/night
      Member Rate
      Fees included
    • 26

      Sleep Inn O'Fallon near I-64

      21.87 mi from destination

      3.39 stars rating. Good. 1320 reviews
      Save 12%
      Strikethrough Rate:$56Discounted rate:$49USD/night
      Member Rate
    • 11

      River City Casino & Hotel

      9.1 mi from destination

      No Reviews Yet
      $155USD/night
      Fees included
    • 42

      Country Inn & Suites by Radisson, St. Peters, MO

      15.65 mi from destination

      4.13 stars rating. Very Good. 206 reviews
      Save 7%
      Strikethrough Rate:$109Discounted rate:$101USD/night
      Member Rate
    • 36

      Comfort Inn Collinsville near St. Louis

      17.61 mi from destination

      4.19 stars rating. Very Good. 1911 reviews
      Save 19%
      Strikethrough Rate:$128Discounted rate:$104USD/night
      Member Rate
    • 28

      Sleep Inn & Suites O'Fallon MO - Technology Drive

      20.46 mi from destination

      4.23 stars rating. Excellent. 1213 reviews
      Save 14%
      Strikethrough Rate:$99Discounted rate:$85USD/night
      Member Rate
    • 26

      Quality Inn O'Fallon IL - St. Louis

      21.13 mi from destination

      3.56 stars rating. Good. 921 reviews
      Save 15%
      Strikethrough Rate:$74Discounted rate:$63USD/night
      Member Rate
    • 29

      Sleep Inn

      15.67 mi from destination

      3.08 stars rating. 1019 reviews
      Save 7%
      Strikethrough Rate:$86Discounted rate:$80USD/night
      Member Rate
    • 31

      Quality Inn & Suites Caseyville - St. Louis

      15.9 mi from destination

      2.73 stars rating. Fair. 705 reviews
      Save 7%
      Strikethrough Rate:$76Discounted rate:$71USD/night
      Member Rate
    • 25

      Hollywood Casino St Louis

      10.63 mi from destination

      No Reviews Yet
      $175USD/night
      Fees included
    • 31

      Econo Lodge Inn & Suites

      13.96 mi from destination

      3.44 stars rating. Good. 371 reviews
      Save 7%
      Strikethrough Rate:$74Discounted rate:$69USD/night
      Member Rate
    • 41

      Comfort Inn Alton near I-255

      20.68 mi from destination

      3.66 stars rating. Good. 850 reviews
      Save 10%
      Strikethrough Rate:$89Discounted rate:$80USD/night
      Member Rate
    • 30

      Comfort Suites Fairview Heights - St Louis

      18.81 mi from destination

      3.46 stars rating. Good. 1773 reviews
      Save 7%
      Strikethrough Rate:$94Discounted rate:$87USD/night
      Member Rate
    • 34

      Comfort Inn Edwardsville - St. Louis

      19.6 mi from destination

      4.17 stars rating. Very Good. 1362 reviews
      Save 10%
      Strikethrough Rate:$138Discounted rate:$124USD/night
      Member Rate
    • 31

      Comfort Inn & Suites St. Louis-O'Fallon

      21.16 mi from destination

      3.68 stars rating. Good. 1859 reviews
      Save 10%
      Strikethrough Rate:$86Discounted rate:$77USD/night
      Member Rate
    • 28

      Econo Lodge Inn & Suites Fairview Heights - St. Louis

      19.36 mi from destination

      3.74 stars rating. Good. 316 reviews
      Save 12%
      Strikethrough Rate:$71Discounted rate:$63USD/night
      Member Rate
    • 10

      Country Inn & Suites by Radisson, Fairview Heights, IL

      18.82 mi from destination

      3.2 stars rating. Good. 217 reviews
      Save 10%
      Strikethrough Rate:$102Discounted rate:$91USD/night
      Member Rate
    • 35

      Comfort Inn Near Six Flags St. Louis

      25.33 mi from destination

      4.05 stars rating. Very Good. 1718 reviews
      Save 7%
      Strikethrough Rate:$120Discounted rate:$111USD/night
      Member Rate
    • 31

      Quality Inn Near Six Flags St. Louis

      25.42 mi from destination

      4 stars rating. Very Good. 653 reviews
      Save 10%
      Strikethrough Rate:$106Discounted rate:$95USD/night
      Member Rate
    • 25

      Radisson Hotel Fairview Heights - St. Louis

      19.39 mi from destination

      3.12 stars rating. Good. 131 reviews
      Save 10%
      Strikethrough Rate:$104Discounted rate:$94USD/night
      Special Rate
    • 31

      Comfort Inn & Suites OFallon - St Louis Area

      21.86 mi from destination

      2.32 stars rating. Fair. 96 reviews
      Save 10%
      Strikethrough Rate:$89Discounted rate:$80USD/night
      Member Rate
    • 32

      The Great Rivers, an Ascend Collection Hotel

      20.75 mi from destination

      2.84 stars rating. Fair. 89 reviews
      Save 5%
      Strikethrough Rate:$115Discounted rate:$109USD/night
      Member Rate
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    • 2

      Radisson Hotel St. Louis Downtown Convention Center

      7.9 mi from destination

      No Reviews Yet
      Coming soonStart booking Oct 29, 2026

    Other Clayton searches

    Good to know

    Number of hotels

    35 hotels in Clayton

    Highest Price

    $175

    Lowest Price

    $49

    Avg. rating

    3.4 (35127 reviews)