Book Boutique Hotels in Depew, NY

Comfort Inn & Suites Buffalo Airport
4345 Genesee Street,
Buffalo, NY, 14225, US
2.59 mi from Depew, NY, US
3.99 stars rating. Good. 576 reviews
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Strikethrough Rate:~~$178~~Discounted rate:$160USD/night
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Sleep Inn & Suites Buffalo Airport
100 Holtz Dr.,
Cheektowaga, NY, 14225, US
2.64 mi from Depew, NY, US
4.2 stars rating. Excellent. 2638 reviews
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Strikethrough Rate:~~$149~~Discounted rate:$142USD/night
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Comfort Inn University
1 Flint Road,
Amherst, NY, 14226, US
7.83 mi from Depew, NY, US
3.88 stars rating. Good. 1810 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$110USD/night
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Quality Inn Near Walden Galleria Mall
475 DINGENS ST,
Cheektowaga, NY, 14206, US
5.68 mi from Depew, NY, US
4.13 stars rating. Very Good. 1344 reviews
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Strikethrough Rate:~~$159~~Discounted rate:$143USD/night
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Sleep Inn Amherst - Buffalo North near University
75 Inn Keepers Lane,
Amherst, NY, 14228, US
9.55 mi from Depew, NY, US
4.37 stars rating. Excellent. 1736 reviews
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Strikethrough Rate:~~$136~~Discounted rate:$122USD/night
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Country Inn & Suites by Radisson, Buffalo South I-90, NY
164B Slade Avenue,
West Seneca, NY, 14224, US
6.99 mi from Depew, NY, US
3.61 stars rating. Good. 317 reviews
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Strikethrough Rate:~~$210~~Discounted rate:$199USD/night
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Comfort Inn & Suites Hamburg - Buffalo South
3615 Commerce Place,
Hamburg, NY, 14075-3638, US
13.85 mi from Depew, NY, US
3.48 stars rating. Good. 1379 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$110USD/night
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Econo Lodge Buffalo South
4344 Milestrip Rd.,
Buffalo, NY, 14219, US
10.12 mi from Depew, NY, US
3.66 stars rating. Good. 1028 reviews
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Strikethrough Rate:~~$99~~Discounted rate:$95USD/night
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Cambria Hotel Niagara Falls
311 Rainbow Blvd,
Niagara Falls, NY, 14303, US
22.3 mi from Depew, NY, US
4.3 stars rating. Excellent. 687 reviews
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Strikethrough Rate:~~$116~~Discounted rate:$111USD/night
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Curtiss Hotel, an Ascend Collection Hotel
210 Franklin Street,
Buffalo, NY, 14202, US
9.34 mi from Depew, NY, US
4.32 stars rating. Excellent. 1533 reviews
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Strikethrough Rate:~~$399~~Discounted rate:$379USD/night
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Comfort Inn & Suites Niagara Falls Blvd USA
6115 Niagara Falls Blvd,
Niagara Falls, NY, 14304, US
19.95 mi from Depew, NY, US
4.36 stars rating. Excellent. 1409 reviews
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Strikethrough Rate:~~$110~~Discounted rate:$107USD/night
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Quality Inn Lockport - Niagara Falls Area
551 South Transit Street,
Lockport, NY, 14094, US
17.14 mi from Depew, NY, US
3.61 stars rating. Good. 665 reviews
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Strikethrough Rate:~~$100~~Discounted rate:$95USD/night
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Econo Lodge Darien Lakes
8493 Alleghany Road,
Corfu, NY, 14036, US
15.98 mi from Depew, NY, US
3.71 stars rating. Good. 795 reviews
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Strikethrough Rate:~~$85~~Discounted rate:$82USD/night
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Comfort Inn The Pointe
1 Prospect Pointe,
Niagara Falls, NY, 14303, US
22.59 mi from Depew, NY, US
4.31 stars rating. Excellent. 4259 reviews
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Strikethrough Rate:~~$111~~Discounted rate:$107USD/night
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Econo Lodge at the Falls North
5919 Niagara Falls Blvd.,
Niagara Falls, NY, 14304, US
20.07 mi from Depew, NY, US
3.77 stars rating. Good. 1634 reviews
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Strikethrough Rate:~~$76~~Discounted rate:$68USD/night
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Quality Inn - Niagara Falls Blvd
7708 Niagara Falls Blvd.,
Niagara Falls, NY, 14304, US
19.22 mi from Depew, NY, US
2.81 stars rating. Fair. 1862 reviews
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Strikethrough Rate:~~$91~~Discounted rate:$87USD/night
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Quality Inn & Suites Palm Island Indoor Waterpark
8250 Park Road,
Batavia, NY, 14020, US
26.15 mi from Depew, NY, US
2.53 stars rating. Fair. 2279 reviews
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Strikethrough Rate:~~$77~~Discounted rate:$73USD/night
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The Giacomo, an Ascend Collection Hotel
222 1st Street,
Niagara Falls, NY, 14303, US
22.51 mi from Depew, NY, US
4.36 stars rating. Excellent. 2169 reviews
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Strikethrough Rate:~~$441~~Discounted rate:$397USD/night
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Comfort Inn & Suites Medina NY near Erie Canal
11591 Maple Ridge Road,
Medina, NY, 14103, US
26.46 mi from Depew, NY, US
3.94 stars rating. Good. 168 reviews
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Strikethrough Rate:~~$260~~Discounted rate:$252USD/night
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Quality Hotel & Suites At The Falls
240 First Street,
Niagara Falls, NY, 14303, US
22.52 mi from Depew, NY, US
3.15 stars rating. Good. 3392 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$114USD/night
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Comfort Inn
1 Hospitality Drive,
Fort Erie, ON, L2A 6G1, CA
12.06 mi from Depew, NY, US
4.16 stars rating. Very Good. 1157 reviews
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Strikethrough Rate:~~$147~~Discounted rate:$140CAD/night
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Comfort Inn Lundy's Lane
7514 Lundys Lane, Building A,
Niagara Falls, ON, L2H 1G8, CA
25.21 mi from Depew, NY, US
3.65 stars rating. Good. 1841 reviews
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Strikethrough Rate:~~$99~~Discounted rate:$95CAD/night
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Comfort Hotel
5700 Stanley Avenue,
Niagara Falls, ON, L2G 3X5, CA
23.73 mi from Depew, NY, US
3.41 stars rating. Good. 936 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$105CAD/night
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Econo Lodge By the Falls
5781 Victoria Ave.,
Niagara Falls, ON, L2G 3L6, CA
23.44 mi from Depew, NY, US
3.34 stars rating. Good. 955 reviews
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Strikethrough Rate:~~$120~~Discounted rate:$114CAD/night
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Country Inn & Suites by Radisson, Niagara Falls, ON
5525 Victoria Avenue,
Niagara Falls, ON, L2G 3L3, CA
23.35 mi from Depew, NY, US
4.32 stars rating. Excellent. 1402 reviews
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Strikethrough Rate:~~$224~~Discounted rate:$222CAD/night
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Comfort Inn Fallsview
6645 Fallsview Blvd,
Niagara Falls, ON, L2G 7G1, CA
23.25 mi from Depew, NY, US
3.63 stars rating. Good. 5298 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$123CAD/night
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Quality Hotel Fallsview Cascade
5305 Murray Street,
Niagara Falls, ON, L2G 2J3, CA
23.29 mi from Depew, NY, US
3.91 stars rating. Good. 3073 reviews
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Strikethrough Rate:~~$180~~Discounted rate:$168CAD/night
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Quality Inn & Suites
5234 Ferry Street,
Niagara Falls, ON, L2G 1R5, CA
23.47 mi from Depew, NY, US
2.93 stars rating. Fair. 1730 reviews
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Strikethrough Rate:~~$125~~Discounted rate:$116CAD/night
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Suburban Studios Buffalo Airport
4217 Genesee Street, Building B,
Buffalo, NY, 14225, US
2.67 mi from Depew, NY, US
2.27 stars rating. Fair. 33 reviews
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NEW TO CHOICE
CenterWay Hotel Tonawanda
225 Crestmount Ave,
Tonawanda, NY, 14150, US
10.92 mi from Depew, NY, US
No Reviews Yet
Coming soonStart booking Apr 01, 2026
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Quality Inn Buffalo Airport
4217 Genesee St., Building A,
Buffalo, NY, 14225, US
2.68 mi from Depew, NY, US
3.21 stars rating. Good. 1202 reviews
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Rodeway Inn Fallsview
6663 Stanley Ave.,
Niagara Falls, ON, L2G 3Y9, CA
23.24 mi from Depew, NY, US
3.85 stars rating. Good. 1363 reviews
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Good to know

Boutique hotels

28 of 32 hotels in Depew

Highest Price

$397

Lowest Price

$68

Avg. rating

28 Boutique hotels near Depew, NY, US

Comfort Inn & Suites Buffalo Airport

Sleep Inn & Suites Buffalo Airport

Comfort Inn University

Quality Inn Near Walden Galleria Mall

Sleep Inn Amherst - Buffalo North near University

Country Inn & Suites by Radisson, Buffalo South I-90, NY

Comfort Inn & Suites Hamburg - Buffalo South

Econo Lodge Buffalo South

Cambria Hotel Niagara Falls

Curtiss Hotel, an Ascend Collection Hotel

Comfort Inn & Suites Niagara Falls Blvd USA

Quality Inn Lockport - Niagara Falls Area

Econo Lodge Darien Lakes

Comfort Inn The Pointe

Econo Lodge at the Falls North

Quality Inn - Niagara Falls Blvd

Quality Inn & Suites Palm Island Indoor Waterpark

The Giacomo, an Ascend Collection Hotel

Comfort Inn & Suites Medina NY near Erie Canal

Quality Hotel & Suites At The Falls

Comfort Inn

Comfort Inn Lundy's Lane

Comfort Hotel

Econo Lodge By the Falls

Country Inn & Suites by Radisson, Niagara Falls, ON

Comfort Inn Fallsview

Quality Hotel Fallsview Cascade

Quality Inn & Suites

Change your dates to book properties below.

Suburban Studios Buffalo Airport

CenterWay Hotel Tonawanda

Quality Inn Buffalo Airport

Rodeway Inn Fallsview

Other Depew searches

Good to know

28 of 32 hotels in Depew

$397

$68

3.6 (50670 reviews)