Book Top Rated Hotels in Guthrie Center, IA

Below are additional hotels in the area that do not match your exact search criteria.

Comfort Inn & Suites West Des Moines
1625 Jordan Creek Parkway,
West Des Moines, IA, 50266, US
36.26 mi from Guthrie Center, IA
4.12 stars rating. Very Good. 604 reviews4.12 stars rating. Very Good. 604 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$110USD/night
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Sleep Inn & Suites Ames near ISU Campus
1310 Dickinson Avenue,
Ames, IA, 50014, US
48.28 mi from Guthrie Center, IA
4.32 stars rating. Excellent. 1319 reviews4.32 stars rating. Excellent. 1319 reviews
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Strikethrough Rate:~~$109~~Discounted rate:$98USD/night
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Quality Inn & Suites Des Moines - Merle Hay Road
4995 N.W. Merle Hay Road,
Des Moines, IA, 50322, US
41.64 mi from Guthrie Center, IA
3.74 stars rating. Good. 1240 reviews3.74 stars rating. Good. 1240 reviews
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Strikethrough Rate:~~$80~~Discounted rate:$68USD/night
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Country Inn & Suites by Radisson, Des Moines West, IA
1350 NW 118th Street,
Clive, IA, 50325, US
37.65 mi from Guthrie Center, IA
4.41 stars rating. Excellent. 438 reviews4.41 stars rating. Excellent. 438 reviews
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Strikethrough Rate:~~$139~~Discounted rate:$135USD/night
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Econo Lodge Inn & Suites Fairgrounds
410 E. 30th Street,
Des Moines, IA, 50317, US
49.1 mi from Guthrie Center, IA
3.4 stars rating. Good. 994 reviews3.4 stars rating. Good. 994 reviews
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Strikethrough Rate:~~$109~~Discounted rate:$93USD/night
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Econo Lodge Ankeny - Des Moines
2602 SE Creekview Drive,
Ankeny, IA, 50021, US
48.1 mi from Guthrie Center, IA
4.36 stars rating. Excellent. 1016 reviews4.36 stars rating. Excellent. 1016 reviews
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Strikethrough Rate:~~$110~~Discounted rate:$99USD/night
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Sleep Inn & Suites West Des Moines near Jordan Creek
885 S. 51st Street,
West Des Moines, IA, 50265, US
38.5 mi from Guthrie Center, IA
4.41 stars rating. Excellent. 1246 reviews4.41 stars rating. Excellent. 1246 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$116USD/night
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Sleep Inn Waukee-West Des Moines
2885 Grand Prairie Parkway, Building A,
Waukee, IA, 50263, US
34.31 mi from Guthrie Center, IA
4.39 stars rating. Excellent. 454 reviews4.39 stars rating. Excellent. 454 reviews
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Strikethrough Rate:~~$144~~Discounted rate:$130USD/night
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Quality Inn & Suites Des Moines Airport
5231 Fleur Drive,
Des Moines, IA, 50321, US
45.35 mi from Guthrie Center, IA
3.44 stars rating. Good. 1035 reviews3.44 stars rating. Good. 1035 reviews
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Strikethrough Rate:~~$95~~Discounted rate:$90USD/night
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Clarion Inn Des Moines Airport
1810 Army Post Road,
Des Moines, IA, 50315, US
45.75 mi from Guthrie Center, IA
2.87 stars rating. Fair. 83 reviews2.87 stars rating. Fair. 83 reviews
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Strikethrough Rate:~~$75~~Discounted rate:$71USD/night
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Comfort Inn & Suites Event Center
929 3rd Street,
Des Moines, IA, 50309, US
45.9 mi from Guthrie Center, IA
4.19 stars rating. Very Good. 3043 reviews4.19 stars rating. Very Good. 3043 reviews
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Strikethrough Rate:~~$159~~Discounted rate:$129USD/night
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Quality Inn & Suites Ankeny-Des Moines
201 SE Delaware Ave,
Ankeny, IA, 50021, US
47.74 mi from Guthrie Center, IA
3.62 stars rating. Good. 934 reviews3.62 stars rating. Good. 934 reviews
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Strikethrough Rate:~~$104~~Discounted rate:$94USD/night
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Radisson Hotel Ames Conference Center at ISU
2609 University Blvd,
Ames, IA, 50010, US
49.76 mi from Guthrie Center, IA
2.8 stars rating. Fair. 138 reviews2.8 stars rating. Fair. 138 reviews
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Strikethrough Rate:~~$122~~Discounted rate:$110USD/night
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Quality Inn
4950 NE 14th Street,
Des Moines, IA, 50313, US
46.6 mi from Guthrie Center, IA
3.36 stars rating. Good. 836 reviews3.36 stars rating. Good. 836 reviews
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Strikethrough Rate:~~$105~~Discounted rate:$100USD/night
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Sleep Inn & Suites Ankeny - Des Moines
2406 SE Tones Drive,
Ankeny, IA, 50021, US
47.93 mi from Guthrie Center, IA
4.34 stars rating. Excellent. 796 reviews4.34 stars rating. Excellent. 796 reviews
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Strikethrough Rate:~~$179~~Discounted rate:$153USD/night
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MainStay Suites Waukee-West Des Moines
2885 Grand Prairie Prkwy., Building B,
Waukee, IA, 50263, US
34.31 mi from Guthrie Center, IA
4.2 stars rating. Excellent. 121 reviews4.2 stars rating. Excellent. 121 reviews
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Strikethrough Rate:~~$154~~Discounted rate:$146USD/night
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Econo Lodge Inn & Suites Walnut
1614 Antique City Drive,
Walnut, IA, 51577, US
39.22 mi from Guthrie Center, IA
3.43 stars rating. Good. 403 reviews3.43 stars rating. Good. 403 reviews
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Strikethrough Rate:~~$75~~Discounted rate:$71USD/night
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Country Inn & Suites by Radisson, Ankeny, IA
2510 SE Tones Dr,
Ankeny, IA, 50021, US
48.08 mi from Guthrie Center, IA
3.45 stars rating. Good. 135 reviews3.45 stars rating. Good. 135 reviews
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Strikethrough Rate:~~$179~~Discounted rate:$170USD/night
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Comfort Inn & Suites Ankeny - Des Moines
215 NE Delaware Ave,
Ankeny, IA, 50021, US
47.81 mi from Guthrie Center, IA
4.32 stars rating. Excellent. 515 reviews4.32 stars rating. Excellent. 515 reviews
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Quality Inn
1258 8th St,
West Des Moines, IA, 50265, US
41.15 mi from Guthrie Center, IA
No Reviews YetNo Reviews Yet
Coming soonStart booking Oct 16, 2025
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Quality Inn
900 S Sumner Avenue,
Creston, IA, 50801, US
43.93 mi from Guthrie Center, IA
4.01 stars rating. Very Good. 250 reviews4.01 stars rating. Very Good. 250 reviews
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Good to know

Top-Rated hotels

21 hotels in Guthrie Center

Highest Price

$170

Lowest Price

$68

Avg. rating

18 Top Rated hotels near Guthrie Center, IA

Below are additional hotels in the area that do not match your exact search criteria.

Comfort Inn & Suites West Des Moines

Sleep Inn & Suites Ames near ISU Campus

Quality Inn & Suites Des Moines - Merle Hay Road

Country Inn & Suites by Radisson, Des Moines West, IA

Econo Lodge Inn & Suites Fairgrounds

Econo Lodge Ankeny - Des Moines

Sleep Inn & Suites West Des Moines near Jordan Creek

Sleep Inn Waukee-West Des Moines

Quality Inn & Suites Des Moines Airport

Clarion Inn Des Moines Airport

Comfort Inn & Suites Event Center

Quality Inn & Suites Ankeny-Des Moines

Radisson Hotel Ames Conference Center at ISU

Quality Inn

Sleep Inn & Suites Ankeny - Des Moines

MainStay Suites Waukee-West Des Moines

Econo Lodge Inn & Suites Walnut

Country Inn & Suites by Radisson, Ankeny, IA

Change your dates to book properties below.

Comfort Inn & Suites Ankeny - Des Moines

Quality Inn

Quality Inn

Other Guthrie Center searches

Good to know

21 hotels in Guthrie Center

$170

$68

3.7 (15600 reviews)