Hotels in Knox City, MO – Choice Hotels

Below are additional hotels in the area that do not match your exact search criteria.

Quality Inn Kirksville
2209 N. Baltimore Street,
Kirksville, MO, 63501, US
49.42 km from Knox City, MO, US
3.76 stars rating. Good. 677 reviews
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Strikethrough Rate:~~$89~~Discounted rate:$76USD/night
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AWARD WINNER
Quality Inn & Suites Keokuk North
3404 Main Street,
Keokuk, IA, 52632, US
59.52 km from Knox City, MO, US
4.27 stars rating. Excellent. 770 reviews
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Strikethrough Rate:~~$120~~Discounted rate:$108USD/night
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AWARD WINNER
Comfort Inn & Suites Macon
1821 N. Missouri St,
Macon, MO, 63552-1973, US
58.02 km from Knox City, MO, US
4.63 stars rating. Exceptional. 1739 reviews
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Strikethrough Rate:~~$140~~Discounted rate:$133USD/night
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Comfort Inn & Suites - Hannibal
4000 Market Street,
Hannibal, MO, 63401, US
72.5 km from Knox City, MO, US
3.6 stars rating. Good. 1161 reviews
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Strikethrough Rate:~~$105~~Discounted rate:$90USD/night
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AWARD WINNER
Quality Inn & Suites Quincy - Downtown
225 S 4th Street,
Quincy, IL, 62301, US
56.22 km from Knox City, MO, US
4.32 stars rating. Excellent. 376 reviews
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Strikethrough Rate:~~$137~~Discounted rate:$123USD/night
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Quality Inn & Suites Fort Madison near Hwy 61
6169 Reve Court,
Fort Madison, IA, 52627, US
74.73 km from Knox City, MO, US
4.25 stars rating. Excellent. 938 reviews
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Strikethrough Rate:~~$106~~Discounted rate:$96USD/night
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Quality Inn & Suites Hannibal West
120 Lindsey Drive, Hwy 36,
Hannibal, MO, 63401, US
68.46 km from Knox City, MO, US
3.96 stars rating. Good. 2609 reviews
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Strikethrough Rate:~~$102~~Discounted rate:$91USD/night
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AWARD WINNER
Sleep Inn & Suites Hannibal West
105 Lakeside Drive,
Hannibal, MO, 63401, US
68.44 km from Knox City, MO, US
4.78 stars rating. Exceptional. 1816 reviews
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Strikethrough Rate:~~$154~~Discounted rate:$139USD/night
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Comfort Inn & Suites Moberly
1801 W Outer Road,
Moberly, MO, 65270, US
85.78 km from Knox City, MO, US
4.22 stars rating. Excellent. 1062 reviews
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Strikethrough Rate:~~$150~~Discounted rate:$136USD/night
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NEW TO CHOICE
Econo Lodge Quincy
224 North 36th Street,
Quincy, IL, 62301, US
60.09 km from Knox City, MO, US
1 star rating. Fair. 1 review
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Strikethrough Rate:~~$70~~Discounted rate:$63USD/night
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NEW TO CHOICE
Quality Inn Fairfield
3001 W. Burlington Ave.,
Fairfield, IA, 52556, US
95.96 km from Knox City, MO, US
No Reviews Yet
Coming soonStart booking 17 Mar 2026
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Good to know

Number of hotels

11 hotels in Knox City

Highest Price

$139

Lowest Price

$63

Avg. rating

10 hotels near Knox City, MO, US

Below are additional hotels in the area that do not match your exact search criteria.

Quality Inn Kirksville

Quality Inn & Suites Keokuk North

Comfort Inn & Suites Macon

Comfort Inn & Suites - Hannibal

Quality Inn & Suites Quincy - Downtown

Quality Inn & Suites Fort Madison near Hwy 61

Quality Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West

Comfort Inn & Suites Moberly

Econo Lodge Quincy

Change your dates to book properties below.

Quality Inn Fairfield

Other Knox City searches

Good to know

11 hotels in Knox City

$139

$63

3.5 (11149 reviews)