Hotels in Saint Charles, MO

Comfort Suites St Charles-St Louis
1400 S. Fifth Street,
Saint Charles, MO, 63301, US
1.14 mi from Saint Charles, MO
4.03 stars rating. Very Good. 2020 reviews4.03 stars rating. Very Good. 2020 reviews
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Strikethrough Rate:~~$149~~Discounted rate:$145USD/night
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Country Inn & Suites by Radisson, St. Charles Historic District
1190 South Main Street,
Saint Charles, MO, 63301, US
0.8 mi from Saint Charles, MO
4.64 stars rating. Exceptional. 466 reviews4.64 stars rating. Exceptional. 466 reviews
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Strikethrough Rate:~~$179~~Discounted rate:$170USD/night
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Country Inn & Suites by Radisson, St. Peters, MO
3877 Veterans Memorial Pkwy,
Saint Peters, MO, 63376, US
4.43 mi from Saint Charles, MO
4.13 stars rating. Very Good. 176 reviews4.13 stars rating. Very Good. 176 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$113USD/night
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Sleep Inn
150 Fountain Lakes Blvd.,
Saint Charles, MO, 63301, US
3.62 mi from Saint Charles, MO
3.09 stars rating. 1011 reviews3.09 stars rating. 1011 reviews
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Strikethrough Rate:~~$100~~Discounted rate:$95USD/night
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Comfort Inn St. Louis Airport
11225 Lone Eagle Dr., Building A,
Bridgeton, MO, 63044, US
5.34 mi from Saint Charles, MO
4.11 stars rating. Very Good. 160 reviews4.11 stars rating. Very Good. 160 reviews
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Strikethrough Rate:~~$127~~Discounted rate:$109USD/night
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Comfort Inn & Suites St. Louis-Hazelwood
7133 Douglas Palmer Place,
Hazelwood, MO, 63042, US
6.76 mi from Saint Charles, MO
4.13 stars rating. Very Good. 1952 reviews4.13 stars rating. Very Good. 1952 reviews
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Strikethrough Rate:~~$125~~Discounted rate:$107USD/night
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Comfort Inn St. Louis - Westport Event Center
12031 Lackland Rd.,
Saint Louis, MO, 63146, US
6.22 mi from Saint Charles, MO
3.59 stars rating. Good. 3031 reviews3.59 stars rating. Good. 3031 reviews
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Strikethrough Rate:~~$120~~Discounted rate:$108USD/night
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WoodSpring Suites St Louis St Charles
2100 Old Hwy 94 S.,
Saint Charles, MO, 63303, US
3.23 mi from Saint Charles, MO
3.22 stars rating. Good. 35 reviews3.22 stars rating. Good. 35 reviews
$91USD/night
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Hollywood Casino St Louis
777 Casino Center Drive,
Maryland Heights, MO, 63043, US
2.03 mi from Saint Charles, MO
No Reviews YetNo Reviews Yet
$365USD/night
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Quality Inn Airport
10232 Natural Bridge Rd.,
Saint Louis, MO, 63134, US
7.43 mi from Saint Charles, MO
3.28 stars rating. Good. 2991 reviews3.28 stars rating. Good. 2991 reviews
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Strikethrough Rate:~~$98~~Discounted rate:$93USD/night
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Quality Inn Florissant-St. Louis
55 Dunn Road,
Florissant, MO, 63031, US
7.85 mi from Saint Charles, MO
3.43 stars rating. Good. 1428 reviews3.43 stars rating. Good. 1428 reviews
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Strikethrough Rate:~~$109~~Discounted rate:$104USD/night
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Comfort Inn & Suites Chesterfield - St. Louis
18375 Chesterfield Arpt. Rd.,
Chesterfield, MO, 63005, US
11.95 mi from Saint Charles, MO
3.93 stars rating. Good. 2412 reviews3.93 stars rating. Good. 2412 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$102USD/night
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Comfort Inn & Suites St. Louis-O'Fallon
100 Comfort Inn Court,
O Fallon, MO, 63366, US
10.68 mi from Saint Charles, MO
3.7 stars rating. Good. 1823 reviews3.7 stars rating. Good. 1823 reviews
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Strikethrough Rate:~~$116~~Discounted rate:$112USD/night
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Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive,
O Fallon, MO, 63368, US
12.95 mi from Saint Charles, MO
4.23 stars rating. Excellent. 1191 reviews4.23 stars rating. Excellent. 1191 reviews
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Strikethrough Rate:~~$115~~Discounted rate:$98USD/night
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Econo Lodge Inn & Suites
3236 W. Chain of Rocks Road,
Granite City, IL, 62040, US
19.44 mi from Saint Charles, MO
3.44 stars rating. Good. 366 reviews3.44 stars rating. Good. 366 reviews
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Strikethrough Rate:~~$77~~Discounted rate:$74USD/night
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The Great Rivers, an Ascend Collection Hotel
3559 College Avenue,
Alton, IL, 62002, US
20.63 mi from Saint Charles, MO
2.69 stars rating. Fair. 74 reviews2.69 stars rating. Fair. 74 reviews
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Strikethrough Rate:~~$109~~Discounted rate:$104USD/night
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Quality Inn & Suites near St. Louis and I-255
1607 Pontiac Drive,
Cahokia, IL, 62206, US
23.23 mi from Saint Charles, MO
3.54 stars rating. Good. 1328 reviews3.54 stars rating. Good. 1328 reviews
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Strikethrough Rate:~~$94~~Discounted rate:$80USD/night
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Comfort Suites St. Louis - Sunset Hills
3654 S. Lindbergh Blvd.,
Saint Louis, MO, 63127, US
16.45 mi from Saint Charles, MO
4.71 stars rating. Exceptional. 1723 reviews4.71 stars rating. Exceptional. 1723 reviews
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Strikethrough Rate:~~$131~~Discounted rate:$124USD/night
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Comfort Inn Alton near I-255
11 Crossroads Ct.,
Alton, IL, 62002, US
20.56 mi from Saint Charles, MO
3.69 stars rating. Good. 834 reviews3.69 stars rating. Good. 834 reviews
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Strikethrough Rate:~~$169~~Discounted rate:$152USD/night
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Comfort Inn & Suites
2625 Lafayette Ave,
Saint Louis, MO, 63104-2011, US
18.17 mi from Saint Charles, MO
3.78 stars rating. Good. 77 reviews3.78 stars rating. Good. 77 reviews
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Strikethrough Rate:~~$134~~Discounted rate:$125USD/night
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MainStay Suites St. Louis - Galleria
8011 Galleria Pkwy,
St. Louis, MO, 63117, US
12.74 mi from Saint Charles, MO
3.25 stars rating. Good. 154 reviews3.25 stars rating. Good. 154 reviews
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Strikethrough Rate:~~$189~~Discounted rate:$162USD/night
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WoodSpring Suites St Louis Arnold
888 Arnold Commons Dr.,
Arnold, MO, 63010, US
24.59 mi from Saint Charles, MO
3.33 stars rating. Good. 36 reviews3.33 stars rating. Good. 36 reviews
$91USD/night
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River City Casino & Hotel
777 River City Casino Boulevard,
Saint Louis, MO, 63125, US
20.99 mi from Saint Charles, MO
No Reviews YetNo Reviews Yet
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Strikethrough Rate:~~$255~~Discounted rate:$219USD/night
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MainStay Suites St. Louis Airport
11225 Lone Eagle Dr., Building B,
Bridgeton, MO, 63044, US
5.33 mi from Saint Charles, MO
3.93 stars rating. Good. 232 reviews3.93 stars rating. Good. 232 reviews
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WoodSpring Suites St Peters-OFallon
7850 Veterans Memorial Parkway,
St. Peters, MO, 63376, US
9.59 mi from Saint Charles, MO
No Reviews YetNo Reviews Yet
Coming soonStart booking Sep 30, 2025
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Good to know

Number of hotels

25 hotels in Saint Charles

Highest Price

$365

Lowest Price

$74

Avg. rating

23 hotels near Saint Charles, MO

Comfort Suites St Charles-St Louis

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Peters, MO

Sleep Inn

Comfort Inn St. Louis Airport

Comfort Inn & Suites St. Louis-Hazelwood

Comfort Inn St. Louis - Westport Event Center

WoodSpring Suites St Louis St Charles

Hollywood Casino St Louis

Quality Inn Airport

Quality Inn Florissant-St. Louis

Comfort Inn & Suites Chesterfield - St. Louis

Comfort Inn & Suites St. Louis-O'Fallon

Sleep Inn & Suites O'Fallon MO - Technology Drive

Econo Lodge Inn & Suites

The Great Rivers, an Ascend Collection Hotel

Quality Inn & Suites near St. Louis and I-255

Comfort Suites St. Louis - Sunset Hills

Comfort Inn Alton near I-255

Comfort Inn & Suites

MainStay Suites St. Louis - Galleria

WoodSpring Suites St Louis Arnold

River City Casino & Hotel

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MainStay Suites St. Louis Airport

WoodSpring Suites St Peters-OFallon

Other Saint Charles searches

Good to know

25 hotels in Saint Charles

$365

$74

3.3 (23520 reviews)