Comfort Inn & Suites Near Medical Center

San Antonio is a major city along the scenic San Antonio River in the south-central part of the state. Home to the world-famous Alamo, the city is rich in colonial history. San  Antonio is also a growing arts-, cultural- and culinary hotspot. Make our smoke-free Comfort Inn & Suites^® Near Medical Center hotel your headquarters for a visit to this great city. Whether you’re in town for business or leisure, we can accommodate your travel needs. We have meeting and event space as well as a business center and a work desk in every room.