Comfort Inn Alton near I-255

You know you’ll be resting your head in a convenient location with classic amenities when you book our Alton Comfort Inn^® Alton near I-255. Located 30 minutes north of St. Louis, Missouri, you’ll not only find spacious guest rooms but also warm and welcoming staff. Hugging the Illinois-Missouri border, our hotel is less than 7 minutes away from the Great River Road and the portion that runs through Alton is a designated National Scenic Byway. Stop by the National Great River Museum before driving along the Road and learn more about it.