Book Quality Hotels in Charleston, MO - Choice Hotels

Change your dates to book properties below.

Comfort Inn & Suites Sikeston I-55
109 Matthews Lane,
Sikeston, MO, 63801, US
10.5 mi from Charleston, MO 63834, USA
4.02 stars rating. Very Good. 1333 reviews4.02 stars rating. Very Good. 1333 reviews
Sold outfor your selected dates
See Availability
Quality Inn Cairo I-57
13201 Kessler Rd, Route 3 and I-57,
Cairo, IL, 62914, US
11.86 mi from Charleston, MO 63834, USA
3.66 stars rating. Good. 557 reviews3.66 stars rating. Good. 557 reviews
Sold outfor your selected dates
See Availability
Quality Inn Charleston - Sikeston
102 Drake St., I-57 ex. 10,
Charleston, MO, 63834, US
0.87 mi from Charleston, MO 63834, USA
3.37 stars rating. Good. 620 reviews3.37 stars rating. Good. 620 reviews
Sold outfor your selected dates
See Availability

Other Charleston searches

All Hotels in Charleston

Boutique Hotels in Charleston

Hotel Deals in Charleston

Extended Stay Hotels in Charleston

Pet Friendly Hotels in Charleston

Top Rated Hotels in Charleston

Good to know

Avg. rating

3.7 (2510 reviews)