Book Boutique Hotels in Clayton, MO | Choice Hotels

Comfort Inn St. Louis - Westport Event Center
12031 Lackland Rd.,
Saint Louis, MO, 63146, US
6.66 mi from Clayton, MO, USA
3.56 stars rating. Good. 3093 reviews3.56 stars rating. Good. 3093 reviews
BOOK NOW AND SAVE 11%
Strikethrough Rate:~~$96~~Discounted rate:$85USD/night
Member Rate
See Availability
Comfort Inn & Suites St. Louis-Hazelwood
7133 Douglas Palmer Place,
Hazelwood, MO, 63042, US
9 mi from Clayton, MO, USA
4.11 stars rating. Very Good. 1980 reviews4.11 stars rating. Very Good. 1980 reviews
BOOK NOW AND SAVE 25%
Strikethrough Rate:~~$97~~Discounted rate:$73USD/night
Member Rate
See Availability
Quality Inn & Suites near St. Louis and I-255
1607 Pontiac Drive,
Cahokia, IL, 62206, US
11.37 mi from Clayton, MO, USA
3.54 stars rating. Good. 1347 reviews3.54 stars rating. Good. 1347 reviews
BOOK NOW AND SAVE 25%
Strikethrough Rate:~~$92~~Discounted rate:$69USD/night
Member Rate
See Availability
NEW TO CHOICE
Comfort Inn & Suites Saint Louis Lafayette Square
2625 Lafayette Ave,
Saint Louis, MO, 63104-2011, US
6.64 mi from Clayton, MO, USA
3.81 stars rating. Good. 98 reviews3.81 stars rating. Good. 98 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$142~~Discounted rate:$132USD/night
Member Rate
See Availability
Stay Longer. Save More.
Say hello to WoodSpring Suites® hotels! Designed for longer stays, we offer contemporary suites with in-room kitchens and free WiFi. Plus, our affordable rates cost less per night when you stay a week, month or more.
See More Hotels
Quality Inn Saint Louis Airport
10232 Natural Bridge Rd.,
Saint Louis, MO, 63134, US
6.02 mi from Clayton, MO, USA
3.27 stars rating. Good. 3035 reviews3.27 stars rating. Good. 3035 reviews
BOOK NOW AND SAVE 6%
Strikethrough Rate:~~$97~~Discounted rate:$91USD/night
Member Rate
See Availability
Comfort Suites St Charles-St Louis
1400 S. Fifth Street,
Saint Charles, MO, 63301, US
11.71 mi from Clayton, MO, USA
4.02 stars rating. Very Good. 2079 reviews4.02 stars rating. Very Good. 2079 reviews
BOOK NOW AND SAVE 6%
Strikethrough Rate:~~$128~~Discounted rate:$120USD/night
Member Rate
See Availability
Quality Inn & Suites Caseyville - St. Louis
2180 Patricia Dr.,
Caseyville, IL, 62232, US
15.9 mi from Clayton, MO, USA
2.72 stars rating. Fair. 710 reviews2.72 stars rating. Fair. 710 reviews
BOOK NOW AND SAVE 25%
Strikethrough Rate:~~$74~~Discounted rate:$55USD/night
Member Rate
See Availability
Comfort Inn & Suites Chesterfield - St. Louis
18375 Chesterfield Arpt. Rd.,
Chesterfield, MO, 63005, US
17.07 mi from Clayton, MO, USA
3.92 stars rating. Good. 2455 reviews3.92 stars rating. Good. 2455 reviews
BOOK NOW AND SAVE 27%
Strikethrough Rate:~~$110~~Discounted rate:$80USD/night
Member Rate
Fees included
See Availability
Sleep Inn O'Fallon near I-64
140 Venita Drive,
O Fallon, IL, 62269, US
21.87 mi from Clayton, MO, USA
3.38 stars rating. Good. 1328 reviews3.38 stars rating. Good. 1328 reviews
BOOK NOW AND SAVE 6%
Strikethrough Rate:~~$58~~Discounted rate:$55USD/night
Member Rate
See Availability
Sleep Inn Saint Charles North
150 Fountain Lakes Blvd.,
Saint Charles, MO, 63301, US
15.67 mi from Clayton, MO, USA
3.07 stars rating. 1027 reviews3.07 stars rating. 1027 reviews
BOOK NOW AND SAVE 6%
Strikethrough Rate:~~$83~~Discounted rate:$78USD/night
Member Rate
See Availability
Comfort Inn Collinsville near St. Louis
8 Commerce Dr.,
Collinsville, IL, 62234, US
17.61 mi from Clayton, MO, USA
4.19 stars rating. Very Good. 1927 reviews4.19 stars rating. Very Good. 1927 reviews
BOOK NOW AND SAVE 28%
Strikethrough Rate:~~$128~~Discounted rate:$92USD/night
Member Rate
See Availability
Comfort Suites Fairview Heights - St Louis
137 Ludwig Drive,
Fairview Heights, IL, 62208, US
18.81 mi from Clayton, MO, USA
3.46 stars rating. Good. 1785 reviews3.46 stars rating. Good. 1785 reviews
BOOK NOW AND SAVE 20%
Strikethrough Rate:~~$92~~Discounted rate:$73USD/night
Member Rate
See Availability
Quality Inn O'Fallon IL - St. Louis
1409 W US 50,
O Fallon, IL, 62269, US
21.13 mi from Clayton, MO, USA
3.56 stars rating. Good. 928 reviews3.56 stars rating. Good. 928 reviews
BOOK NOW AND SAVE 15%
Strikethrough Rate:~~$66~~Discounted rate:$57USD/night
Member Rate
See Availability
Comfort Inn Alton near I-255
11 Crossroads Ct.,
Alton, IL, 62002, US
20.68 mi from Clayton, MO, USA
3.66 stars rating. Good. 859 reviews3.66 stars rating. Good. 859 reviews
BOOK NOW AND SAVE 24%
Strikethrough Rate:~~$101~~Discounted rate:$77USD/night
Member Rate
See Availability
Comfort Inn Edwardsville - St. Louis
3080 S. SR 157,
Edwardsville, IL, 62025, US
19.6 mi from Clayton, MO, USA
4.16 stars rating. Very Good. 1370 reviews4.16 stars rating. Very Good. 1370 reviews
BOOK NOW AND SAVE 24%
Strikethrough Rate:~~$131~~Discounted rate:$100USD/night
Member Rate
See Availability
Comfort Inn & Suites St. Louis-O'Fallon
8170 Veterans Memorial Pkwy,
O Fallon, MO, 63366, US
21.16 mi from Clayton, MO, USA
3.68 stars rating. Good. 1877 reviews3.68 stars rating. Good. 1877 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$89~~Discounted rate:$80USD/night
Member Rate
See Availability
Quality Inn Pacific near Six Flags St. Louis
1400 West Osage St.,
Pacific, MO, 63069, US
25.42 mi from Clayton, MO, USA
4 stars rating. Very Good. 657 reviews4 stars rating. Very Good. 657 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$105~~Discounted rate:$94USD/night
Member Rate
See Availability
Comfort Inn Near Six Flags St. Louis
1320 Thornton St.,
Pacific, MO, 63069, US
25.33 mi from Clayton, MO, USA
4.05 stars rating. Very Good. 1739 reviews4.05 stars rating. Very Good. 1739 reviews
BOOK NOW AND SAVE 6%
Strikethrough Rate:~~$111~~Discounted rate:$104USD/night
Member Rate
See Availability

Change your dates to book properties below.

EXTENDED STAY
MainStay Suites St. Louis - Galleria
8011 Galleria Pkwy,
St. Louis, MO, 63117, US
1.19 mi from Clayton, MO, USA
3.22 stars rating. Good. 175 reviews3.22 stars rating. Good. 175 reviews
Sold outfor your selected dates
See Availability
EXTENDED STAY
MainStay Suites St. Louis Airport
11225 Lone Eagle Dr., Building B,
Bridgeton, MO, 63044, US
7.12 mi from Clayton, MO, USA
3.93 stars rating. Good. 234 reviews3.93 stars rating. Good. 234 reviews
Sold outfor your selected dates
See Availability
AWARD WINNER
Comfort Suites St. Louis - Sunset Hills
3654 S. Lindbergh Blvd.,
Saint Louis, MO, 63127, US
7.69 mi from Clayton, MO, USA
4.72 stars rating. Exceptional. 1877 reviews4.72 stars rating. Exceptional. 1877 reviews
Sold outfor your selected dates
See Availability
Comfort Inn St. Louis Airport
11225 Lone Eagle Dr., Building A,
Bridgeton, MO, 63044, US
7.1 mi from Clayton, MO, USA
4.05 stars rating. Very Good. 183 reviews4.05 stars rating. Very Good. 183 reviews
Sold outfor your selected dates
See Availability
Quality Inn Florissant-St. Louis
55 Dunn Road,
Florissant, MO, 63031, US
8.71 mi from Clayton, MO, USA
3.41 stars rating. Good. 1454 reviews3.41 stars rating. Good. 1454 reviews
Sold outfor your selected dates
See Availability
NEW TO CHOICE
Radisson Hotel St. Louis Downtown Convention Center
811 N 9th St,
St. Louis, MO, 63101, US
7.9 mi from Clayton, MO, USA
1.5 stars rating. Fair. 16 reviews1.5 stars rating. Fair. 16 reviews
Sold outfor your selected dates
See Availability
Hollywood Casino St Louis
777 Casino Center Drive,
Maryland Heights, MO, 63043, US
10.63 mi from Clayton, MO, USA
No Reviews YetNo Reviews Yet
Sold outfor your selected dates
See Availability
River City Casino & Hotel
777 River City Casino Boulevard,
Saint Louis, MO, 63125, US
9.1 mi from Clayton, MO, USA
No Reviews YetNo Reviews Yet
Sold outfor your selected dates
See Availability
AWARD WINNER
Country Inn & Suites by Radisson, St. Charles Historic District
1190 South Main Street,
Saint Charles, MO, 63301, US
11.65 mi from Clayton, MO, USA
4.65 stars rating. Exceptional. 595 reviews4.65 stars rating. Exceptional. 595 reviews
Sold outfor your selected dates
See Availability
Country Inn & Suites by Radisson, Fairview Heights, IL
140 Ludwig Drive,
Fairview Heights, IL, 62208, US
18.82 mi from Clayton, MO, USA
3.21 stars rating. Good. 223 reviews3.21 stars rating. Good. 223 reviews
Sold outfor your selected dates
See Availability
Country Inn & Suites by Radisson, St. Peters, MO
3877 Veterans Memorial Pkwy,
Saint Peters, MO, 63376, US
15.65 mi from Clayton, MO, USA
4.13 stars rating. Very Good. 215 reviews4.13 stars rating. Very Good. 215 reviews
Sold outfor your selected dates
See Availability
Econo Lodge Inn & Suites Granite City - St. Louis
3236 W. Chain of Rocks Road,
Granite City, IL, 62040, US
13.96 mi from Clayton, MO, USA
3.43 stars rating. Good. 376 reviews3.43 stars rating. Good. 376 reviews
Sold outfor your selected dates
See Availability
Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive,
O Fallon, MO, 63368, US
20.46 mi from Clayton, MO, USA
4.23 stars rating. Excellent. 1225 reviews4.23 stars rating. Excellent. 1225 reviews
Sold outfor your selected dates
See Availability
Comfort Inn & Suites OFallon - St Louis Area
116 Regency Park,
O'Fallon, IL, 62269, US
21.86 mi from Clayton, MO, USA
2.36 stars rating. Fair. 105 reviews2.36 stars rating. Fair. 105 reviews
Sold outfor your selected dates
See Availability
Radisson Hotel Fairview Heights - St. Louis
319 Fountains Pkwy,
Fairview Heights, IL, 62208, US
19.39 mi from Clayton, MO, USA
3.15 stars rating. Good. 138 reviews3.15 stars rating. Good. 138 reviews
Sold outfor your selected dates
See Availability
Econo Lodge Inn & Suites Fairview Heights - St. Louis
305 Salem Place,
Fairview Heights, IL, 62208, US
19.36 mi from Clayton, MO, USA
3.74 stars rating. Good. 318 reviews3.74 stars rating. Good. 318 reviews
Sold outfor your selected dates
See Availability
NEW TO CHOICE
The Great Rivers, an Ascend Collection Hotel
3559 College Avenue,
Alton, IL, 62002, US
20.75 mi from Clayton, MO, USA
2.86 stars rating. Fair. 93 reviews2.86 stars rating. Fair. 93 reviews
Sold outfor your selected dates
See Availability

Other Clayton searches

All Hotels in Clayton

Hotel Deals in Clayton

Extended Stay Hotels in Clayton

Pet Friendly Hotels in Clayton

Top Rated Hotels in Clayton

Good to know

Boutique hotels

35 hotels in Clayton

Highest Price

$132

Lowest Price

$55

Avg. rating

3.4 (35521 reviews)