Conveniently located off Interstate 72 near the Hannibal Regional Airport, our hotel puts you in close proximity to several area attractions. Explore Mark Twain’s history at the Mark Twain Boyhood Home and Museum, just a short drive from our hotel. Guests can also easily get to the Mark Twain Cave and Campground as well as Mark Twain Riverboat, featuring sightseeing and dinner riverboat cruises along the Mississippi River.

When you’re ready to settle in for a great night’s rest, retreat to one of our cozy guest rooms, specifically designed for optimal sleep with a warm and modern feel. Each room features practical amenities such as a microwave, refrigerator and coffee maker. Relax with a 39-inch flat-screen TV and enjoy the convenience of an in-room hair dryer, iron and ironing board.

Sleep Inn & Suites

Available Guest Rooms