Extended Stay Hotels in Saint Charles, MO

MainStay Suites St. Louis Airport
11225 Lone Eagle Dr., Building B,
Bridgeton, MO, 63044, US
5.33 mi from St Charles, MO, USA
3.93 stars rating. Good. 234 reviews3.93 stars rating. Good. 234 reviews
BOOK NOW AND SAVE 16%
Strikethrough Rate:~~$116~~Discounted rate:$97USD/night
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MainStay Suites St. Louis - Galleria
8011 Galleria Pkwy,
St. Louis, MO, 63117, US
12.74 mi from St Charles, MO, USA
3.24 stars rating. Good. 161 reviews3.24 stars rating. Good. 161 reviews
BOOK NOW AND SAVE 16%
Strikethrough Rate:~~$149~~Discounted rate:$125USD/night
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Below are additional hotels in the area that do not match your exact search criteria.

Hollywood Casino St Louis
777 Casino Center Drive,
Maryland Heights, MO, 63043, US
2.03 mi from St Charles, MO, USA
No Reviews YetNo Reviews Yet
BOOK NOW AND SAVE 18%
Strikethrough Rate:~~$145~~Discounted rate:$119USD/night
Special Rate
Fees included
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Country Inn & Suites by Radisson, St. Charles Historic District
1190 South Main Street,
Saint Charles, MO, 63301, US
0.8 mi from St Charles, MO, USA
4.65 stars rating. Exceptional. 526 reviews4.65 stars rating. Exceptional. 526 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$214~~Discounted rate:$199USD/night
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Sleep Inn
150 Fountain Lakes Blvd.,
Saint Charles, MO, 63301, US
3.62 mi from St Charles, MO, USA
3.08 stars rating. 1017 reviews3.08 stars rating. 1017 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$86~~Discounted rate:$80USD/night
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Country Inn & Suites by Radisson, St. Peters, MO
3877 Veterans Memorial Pkwy,
Saint Peters, MO, 63376, US
4.43 mi from St Charles, MO, USA
4.13 stars rating. Very Good. 200 reviews4.13 stars rating. Very Good. 200 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$119~~Discounted rate:$111USD/night
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Comfort Suites St Charles-St Louis
1400 S. Fifth Street,
Saint Charles, MO, 63301, US
1.14 mi from St Charles, MO, USA
4.03 stars rating. Very Good. 2048 reviews4.03 stars rating. Very Good. 2048 reviews
BOOK NOW AND SAVE 12%
Strikethrough Rate:~~$174~~Discounted rate:$154USD/night
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Comfort Inn & Suites St. Louis-Hazelwood
7133 Douglas Palmer Place,
Hazelwood, MO, 63042, US
6.76 mi from St Charles, MO, USA
4.12 stars rating. Very Good. 1972 reviews4.12 stars rating. Very Good. 1972 reviews
BOOK NOW AND SAVE 12%
Strikethrough Rate:~~$98~~Discounted rate:$87USD/night
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Comfort Inn St. Louis - Westport Event Center
12031 Lackland Rd.,
Saint Louis, MO, 63146, US
6.22 mi from St Charles, MO, USA
3.58 stars rating. Good. 3051 reviews3.58 stars rating. Good. 3051 reviews
BOOK NOW AND SAVE 12%
Strikethrough Rate:~~$99~~Discounted rate:$87USD/night
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Comfort Inn St. Louis Airport
11225 Lone Eagle Dr., Building A,
Bridgeton, MO, 63044, US
5.34 mi from St Charles, MO, USA
4.09 stars rating. Very Good. 170 reviews4.09 stars rating. Very Good. 170 reviews
BOOK NOW AND SAVE 16%
Strikethrough Rate:~~$116~~Discounted rate:$97USD/night
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Quality Inn Airport
10232 Natural Bridge Rd.,
Saint Louis, MO, 63134, US
7.43 mi from St Charles, MO, USA
3.28 stars rating. Good. 3011 reviews3.28 stars rating. Good. 3011 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$66~~Discounted rate:$62USD/night
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Quality Inn Florissant-St. Louis
55 Dunn Road,
Florissant, MO, 63031, US
7.85 mi from St Charles, MO, USA
3.42 stars rating. Good. 1435 reviews3.42 stars rating. Good. 1435 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$75~~Discounted rate:$70USD/night
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Comfort Inn & Suites Chesterfield - St. Louis
18375 Chesterfield Arpt. Rd.,
Chesterfield, MO, 63005, US
11.95 mi from St Charles, MO, USA
3.93 stars rating. Good. 2427 reviews3.93 stars rating. Good. 2427 reviews
BOOK NOW AND SAVE 14%
Strikethrough Rate:~~$109~~Discounted rate:$93USD/night
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Comfort Inn & Suites St. Louis-O'Fallon
100 Comfort Inn Court,
O Fallon, MO, 63366, US
10.68 mi from St Charles, MO, USA
3.69 stars rating. Good. 1843 reviews3.69 stars rating. Good. 1843 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$95~~Discounted rate:$85USD/night
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Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive,
O Fallon, MO, 63368, US
12.95 mi from St Charles, MO, USA
4.23 stars rating. Excellent. 1205 reviews4.23 stars rating. Excellent. 1205 reviews
BOOK NOW AND SAVE 15%
Strikethrough Rate:~~$105~~Discounted rate:$90USD/night
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Comfort Suites St. Louis - Sunset Hills
3654 S. Lindbergh Blvd.,
Saint Louis, MO, 63127, US
16.45 mi from St Charles, MO, USA
4.71 stars rating. Exceptional. 1795 reviews4.71 stars rating. Exceptional. 1795 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$124~~Discounted rate:$115USD/night
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Comfort Inn Alton near I-255
11 Crossroads Ct.,
Alton, IL, 62002, US
20.56 mi from St Charles, MO, USA
3.67 stars rating. Good. 841 reviews3.67 stars rating. Good. 841 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$94~~Discounted rate:$85USD/night
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Econo Lodge Inn & Suites
3236 W. Chain of Rocks Road,
Granite City, IL, 62040, US
19.44 mi from St Charles, MO, USA
3.45 stars rating. Good. 368 reviews3.45 stars rating. Good. 368 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$73~~Discounted rate:$68USD/night
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Quality Inn & Suites near St. Louis and I-255
1607 Pontiac Drive,
Cahokia, IL, 62206, US
23.23 mi from St Charles, MO, USA
3.54 stars rating. Good. 1338 reviews3.54 stars rating. Good. 1338 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$79~~Discounted rate:$73USD/night
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River City Casino & Hotel
777 River City Casino Boulevard,
Saint Louis, MO, 63125, US
20.99 mi from St Charles, MO, USA
No Reviews YetNo Reviews Yet
BOOK NOW AND SAVE 18%
Strikethrough Rate:~~$155~~Discounted rate:$127USD/night
Special Rate
Fees included
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Comfort Inn & Suites
2625 Lafayette Ave,
Saint Louis, MO, 63104-2011, US
18.17 mi from St Charles, MO, USA
3.81 stars rating. Good. 89 reviews3.81 stars rating. Good. 89 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$119~~Discounted rate:$111USD/night
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The Great Rivers, an Ascend Collection Hotel
3559 College Avenue,
Alton, IL, 62002, US
20.63 mi from St Charles, MO, USA
2.79 stars rating. Fair. 81 reviews2.79 stars rating. Fair. 81 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$104~~Discounted rate:$99USD/night
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Change your dates to book properties below.

Radisson Hotel St. Louis Downtown Convention Center
811 N 9th St,
St. Louis, MO, 63101, US
18.73 mi from St Charles, MO, USA
No Reviews YetNo Reviews Yet
Coming soonStart booking Oct 29, 2026
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Good to know

Extended stay hotels

2 of 23 hotels in Saint Charles

Highest Price

$199

Lowest Price

$62

Avg. rating

3.3 (23812 reviews)

Weekly Rate

$434

Monthly Rate

2 Extended Stay hotels near St Charles, MO, USA match your filters

MainStay Suites St. Louis Airport

MainStay Suites St. Louis - Galleria

Below are additional hotels in the area that do not match your exact search criteria.

Hollywood Casino St Louis

Country Inn & Suites by Radisson, St. Charles Historic District

Sleep Inn

Country Inn & Suites by Radisson, St. Peters, MO

Comfort Suites St Charles-St Louis

Comfort Inn & Suites St. Louis-Hazelwood

Comfort Inn St. Louis - Westport Event Center

Comfort Inn St. Louis Airport

Quality Inn Airport

Quality Inn Florissant-St. Louis

Comfort Inn & Suites Chesterfield - St. Louis

Comfort Inn & Suites St. Louis-O'Fallon

Sleep Inn & Suites O'Fallon MO - Technology Drive

Comfort Suites St. Louis - Sunset Hills

Comfort Inn Alton near I-255

Econo Lodge Inn & Suites

Quality Inn & Suites near St. Louis and I-255

River City Casino & Hotel

Comfort Inn & Suites

The Great Rivers, an Ascend Collection Hotel

Change your dates to book properties below.

Radisson Hotel St. Louis Downtown Convention Center

Other Saint Charles searches

Good to know

2 of 23 hotels in Saint Charles

$199

$62

3.3 (23812 reviews)

$434

$1,860