35 hotels near San Luis, MO, US

35 hotels near San Luis, MO, US

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    • Quality Inn & Suites near St. Louis and I-255

      1607 Pontiac Drive,
      Cahokia, IL, 62206, US
      3.52 stars rating. Good. 1360 reviews

      BOOK NOW AND SAVE 16%

      Strikethrough Rate:$103Discounted rate:$86USD/night
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    • Sleep Inn O'Fallon near I-64

      140 Venita Drive,
      O Fallon, IL, 62269, US
      3.36 stars rating. Good. 1359 reviews

      BOOK NOW AND SAVE 7%

      Strikethrough Rate:$81Discounted rate:$75USD/night
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    • Econo Lodge Inn & Suites Fairview Heights - St. Louis

      305 Salem Place,
      Fairview Heights, IL, 62208, US
      3.78 stars rating. Good. 332 reviews
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    • MainStay Suites St. Louis - Galleria

      8011 Galleria Pkwy,
      St. Louis, MO, 63117, US
      3.14 stars rating. Good. 212 reviews
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    • MainStay Suites St. Louis Airport

      11225 Lone Eagle Dr., Building B,
      Bridgeton, MO, 63044, US
      3.92 stars rating. Good. 244 reviews
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    • Comfort Inn & Suites OFallon - St Louis Area

      116 Regency Park,
      O'Fallon, IL, 62269, US
      2.35 stars rating. Fair. 129 reviews
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    • AWARD WINNER

      Country Inn & Suites by Radisson, St. Charles Historic District

      1190 South Main Street,
      Saint Charles, MO, 63301, US
      4.64 stars rating. Exceptional. 688 reviews
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    • AWARD WINNER

      Comfort Suites St. Louis - Sunset Hills

      3654 S. Lindbergh Blvd.,
      Saint Louis, MO, 63127, US
      4.73 stars rating. Exceptional. 2066 reviews
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    • NEW TO CHOICE

      Comfort Inn & Suites Saint Louis Lafayette Square

      2625 Lafayette Ave,
      Saint Louis, MO, 63104-2011, US
      3.79 stars rating. Good. 127 reviews
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    • Country Inn & Suites by Radisson, Fairview Heights, IL

      140 Ludwig Drive,
      Fairview Heights, IL, 62208, US
      3.16 stars rating. Good. 243 reviews
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    • Comfort Inn & Suites Hazelwood - St. Louis

      7133 Douglas Palmer Place,
      Hazelwood, MO, 63042, US
      4.09 stars rating. Very Good. 2011 reviews
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    • Comfort Inn Alton near I-255

      11 Crossroads Ct.,
      Alton, IL, 62002, US
      3.64 stars rating. Good. 869 reviews
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    • NEW HOTEL

      WoodSpring Suites St Peters-OFallon

      7850 Veterans Memorial Parkway,
      St. Peters, MO, 63376, US
      No Reviews Yet
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    • Comfort Inn & Suites St. Louis-O'Fallon

      8170 Veterans Memorial Pkwy,
      O Fallon, MO, 63366, US
      3.67 stars rating. Good. 1934 reviews
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    • NEW TO CHOICE

      Radisson Hotel St. Louis Downtown Convention Center

      811 N 9th St,
      St. Louis, MO, 63101, US
      1.43 stars rating. Fair. 122 reviews
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    • Hollywood Casino St Louis

      777 Casino Center Drive,
      Maryland Heights, MO, 63043, US
      No Reviews Yet
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    • Econo Lodge Inn & Suites Granite City - St. Louis

      3236 W. Chain of Rocks Road,
      Granite City, IL, 62040, US
      3.46 stars rating. Good. 396 reviews
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    • NEW TO CHOICE

      Radisson Hotel Fairview Heights - St. Louis

      319 Fountains Pkwy,
      Fairview Heights, IL, 62208, US
      3.52 stars rating. Good. 227 reviews
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    • WoodSpring Suites St Louis St Charles

      2100 Old Hwy 94 S.,
      Saint Charles, MO, 63303, US
      3.22 stars rating. Good. 35 reviews
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    • Sleep Inn & Suites O'Fallon MO - Technology Drive

      1147 Technology Drive,
      O Fallon, MO, 63368, US
      4.23 stars rating. Excellent. 1284 reviews
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    • Comfort Inn St. Louis Airport

      11225 Lone Eagle Dr., Building A,
      Bridgeton, MO, 63044, US
      4.06 stars rating. Very Good. 193 reviews
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    • NEW TO CHOICE

      The Great Rivers, an Ascend Collection Hotel

      3559 College Avenue,
      Alton, IL, 62002, US
      2.91 stars rating. Fair. 114 reviews
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    • Comfort Suites St Charles-St Louis

      1400 S. Fifth Street,
      Saint Charles, MO, 63301, US
      4.02 stars rating. Very Good. 2116 reviews
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    • River City Casino & Hotel

      777 River City Casino Boulevard,
      Saint Louis, MO, 63125, US
      No Reviews Yet
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    • Comfort Suites Fairview Heights - St Louis

      137 Ludwig Drive,
      Fairview Heights, IL, 62208, US
      3.45 stars rating. Good. 1823 reviews
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    • Quality Inn Florissant-St. Louis

      55 Dunn Road,
      Florissant, MO, 63031, US
      3.41 stars rating. Good. 1484 reviews
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    • Quality Inn O'Fallon IL - St. Louis

      1409 W US 50,
      O Fallon, IL, 62269, US
      3.54 stars rating. Good. 959 reviews
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    • Country Inn & Suites by Radisson, St. Peters, MO

      3877 Veterans Memorial Pkwy,
      Saint Peters, MO, 63376, US
      4.04 stars rating. Very Good. 238 reviews
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    • Quality Inn Saint Louis Airport

      10232 Natural Bridge Rd.,
      Saint Louis, MO, 63134, US
      3.26 stars rating. Good. 3082 reviews
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    • Comfort Inn Collinsville near St. Louis

      8 Commerce Dr.,
      Collinsville, IL, 62234, US
      4.2 stars rating. Excellent. 1986 reviews
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    • Comfort Inn & Suites Chesterfield - St. Louis

      18375 Chesterfield Arpt. Rd.,
      Chesterfield, MO, 63005, US
      3.89 stars rating. Good. 2523 reviews
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    • Quality Inn & Suites Caseyville - St. Louis

      2180 Patricia Dr.,
      Caseyville, IL, 62232, US
      2.7 stars rating. Fair. 723 reviews
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    • Comfort Inn Edwardsville - St. Louis

      3080 S. SR 157,
      Edwardsville, IL, 62025, US
      4.16 stars rating. Very Good. 1387 reviews
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    • Sleep Inn Saint Charles North

      150 Fountain Lakes Blvd.,
      Saint Charles, MO, 63301, US
      3.08 stars rating. Fair. 1051 reviews
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    • AWARD WINNER

      WoodSpring Suites St Louis Arnold

      888 Arnold Commons Dr.,
      Arnold, MO, 63010, US
      3.33 stars rating. Good. 36 reviews
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    Discover the Gateway City of St Louis, Missouri

    St Louis stands as the Gateway to the West, offering visitors iconic architecture and rich American expansion heritage along the Mississippi River. The community features the Gateway Arch, historic districts, and cultural attractions that celebrate both westward expansion and urban renewal. Visitors can explore the famous arch, enjoy riverfront recreation, or discover the area's significant role in American territorial development. The architectural icon and historical significance create distinctive Missouri experiences. Choice Hotels provides convenient access to Gateway Arch attractions while serving as excellent bases for exploring St Louis's historical and cultural offerings.

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    San Luis hotels by brand

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    Number of hotels

    35 hotels in San Luis

    Highest Price

    $86

    Lowest Price

    $75

    Avg. rating

    3.6 (31353 reviews)