Book Mainstay Hotels in Florence, SC - Choice Hotels

1 of 12 hotels near Florence, SC match your filters

Show points

Pet friendly

Pool

MainStay Suites
1819 West Lucas Street, Building B,
Florence, SC, 29501, US
2.79 mi from Florence, SC
1.92 stars rating. Fair. 50 reviews1.92 stars rating. Fair. 50 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$65~~Discounted rate:$60USD/night
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Below are additional hotels in the area that do not match your exact search criteria.

Clarion Inn & Suites
1819 West Lucas Street, Building A,
Florence, SC, 29501, US
2.75 mi from Florence, SC
1.92 stars rating. Fair. 192 reviews1.92 stars rating. Fair. 192 reviews
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Strikethrough Rate:~~$61~~Discounted rate:$57USD/night
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Suburban Studios Florence - Darlington
1914 West Lucas Street, I-95 & US 52,
Florence, SC, 29501, US
2.84 mi from Florence, SC
2.92 stars rating. Fair. 1317 reviews2.92 stars rating. Fair. 1317 reviews
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Strikethrough Rate:~~$55~~Discounted rate:$51USD/night
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Sleep Inn Florence North
1833 Florence Park Dr., I-95 & US 52,
Florence, SC, 29501, US
3.31 mi from Florence, SC
3.74 stars rating. Good. 1964 reviews3.74 stars rating. Good. 1964 reviews
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Strikethrough Rate:~~$80~~Discounted rate:$74USD/night
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Country Inn & Suites by Radisson, Florence, SC
1739 Mandeville Road,
Florence, SC, 29501-7026, US
3.07 mi from Florence, SC
3.19 stars rating. Good. 266 reviews3.19 stars rating. Good. 266 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$136~~Discounted rate:$122USD/night
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Econo Lodge
1920 West Lucas Street,
Florence, SC, 29501, US
2.86 mi from Florence, SC
2.87 stars rating. Fair. 1347 reviews2.87 stars rating. Fair. 1347 reviews
BOOK NOW AND SAVE 12%
Strikethrough Rate:~~$60~~Discounted rate:$53USD/night
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Quality Inn & Suites Florence Civic Center
150 Dunbarton Drive,
Florence, SC, 29501, US
4.24 mi from Florence, SC
3.95 stars rating. Good. 1722 reviews3.95 stars rating. Good. 1722 reviews
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Strikethrough Rate:~~$100~~Discounted rate:$93USD/night
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Comfort Suites Florence I-95
2120 West Lucas Street,
Florence, SC, 29501, US
3.32 mi from Florence, SC
4.27 stars rating. Excellent. 2580 reviews4.27 stars rating. Excellent. 2580 reviews
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Strikethrough Rate:~~$134~~Discounted rate:$127USD/night
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Comfort Inn & Suites
527 Woody Jones Blvd.,
Florence, SC, 29501, US
3.9 mi from Florence, SC
4.5 stars rating. Excellent. 1146 reviews4.5 stars rating. Excellent. 1146 reviews
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Strikethrough Rate:~~$146~~Discounted rate:$139USD/night
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Park Inn by Radisson Florence, SC
1729 Mandeville Road,
Florence, SC, 29501, US
3.06 mi from Florence, SC
4.27 stars rating. Excellent. 314 reviews4.27 stars rating. Excellent. 314 reviews
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Strikethrough Rate:~~$111~~Discounted rate:$105USD/night
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Quality Inn
903 South Fifth Street,
Hartsville, SC, 29550, US
20.62 mi from Florence, SC
2.94 stars rating. Fair. 389 reviews2.94 stars rating. Fair. 389 reviews
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Strikethrough Rate:~~$76~~Discounted rate:$70USD/night
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Quality Inn & Suites
202 North Ron McNair Blvd.,
Lake City, SC, 29560, US
22.06 mi from Florence, SC
3.34 stars rating. Good. 95 reviews3.34 stars rating. Good. 95 reviews
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Strikethrough Rate:~~$137~~Discounted rate:$128USD/night
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Rodeway Inn
415 S. Irby St.,
Florence, SC, 29501, US
0.46 mi from Florence, SC
No Reviews YetNo Reviews Yet
Coming soonStart booking Jul 31, 2025
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Good to know

Number of hotels

12 of 13 hotels in Florence

Highest Price

$139

Lowest Price

$51

Avg. rating

3.1 (11382 reviews)