9 hotels near Santee, SC

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Pet friendly

Pool

Comfort Inn & Suites Santee I-95
221 Britain Street,
Santee, SC, 29142, US
0.92 mi from Santee, SC
3.92 stars rating. Good. 1704 reviews3.92 stars rating. Good. 1704 reviews
BOOK NOW AND SAVE 19%
Strikethrough Rate:~~$129~~Discounted rate:$104USD/night
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Quality Inn & Suites
8929 Old Number Six Highway,
Santee, SC, 29142, US
1.08 mi from Santee, SC
2.46 stars rating. Fair. 232 reviews2.46 stars rating. Fair. 232 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$84~~Discounted rate:$78USD/night
Hotel Service Fee: $5 per room per night
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Econo Lodge
9112 Old Number 6 Hwy,
Santee, SC, 29142, US
1.32 mi from Santee, SC
3 stars rating. Fair. 167 reviews3 stars rating. Fair. 167 reviews
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Strikethrough Rate:~~$80~~Discounted rate:$74USD/night
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Quality Inn & Suites
3671 Saint Matthews Road, Building A,
Orangeburg, SC, 29118, US
20.37 mi from Santee, SC
3.41 stars rating. Good. 1714 reviews3.41 stars rating. Good. 1714 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$70~~Discounted rate:$67USD/night
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Comfort Inn & Suites
746 Citadel Road,
Orangeburg, SC, 29118, US
20.26 mi from Santee, SC
3.92 stars rating. Good. 1589 reviews3.92 stars rating. Good. 1589 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$129~~Discounted rate:$120USD/night
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Econo Lodge
5971 West Jim Bilton Blvd.,
Saint George, SC, 29477, US
20.44 mi from Santee, SC
3.05 stars rating. 351 reviews3.05 stars rating. 351 reviews
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Strikethrough Rate:~~$69~~Discounted rate:$64USD/night
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Suburban Studios
3671 Saint Matthews Road, Building B,
Orangeburg, SC, 29118, US
20.43 mi from Santee, SC
4.14 stars rating. Very Good. 79 reviews4.14 stars rating. Very Good. 79 reviews
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Strikethrough Rate:~~$77~~Discounted rate:$72USD/night
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Sleep Inn
3689 St. Matthews Rd,
Orangeburg, SC, 29118, US
20.36 mi from Santee, SC
3.89 stars rating. Good. 1271 reviews3.89 stars rating. Good. 1271 reviews
BOOK NOW AND SAVE 16%
Strikethrough Rate:~~$115~~Discounted rate:$96USD/night
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Quality Inn Manning I-95
3031 Paxville Highway,
Manning, SC, 29102, US
21.09 mi from Santee, SC
3.99 stars rating. Good. 117 reviews3.99 stars rating. Good. 117 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$110~~Discounted rate:$102USD/night
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Palmetto Inn
6137 Alex Harvin Hwy,
Manning, SC, 29102, US
16.71 mi from Santee, SC
No Reviews YetNo Reviews Yet
Coming soonStart booking Aug 02, 2025
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Number of hotels

10 hotels in Santee

Highest Price

$120

Lowest Price

$64

Avg. rating

3.2 (7224 reviews)