7 hotels near Santee, SC

Show points

Pet friendly

Pool

Quality Inn & Suites
8929 Old Number Six Highway,
Santee, SC, 29142, US
1.08 mi from Santee, SC
2.46 stars rating. Fair. 232 reviews2.46 stars rating. Fair. 232 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$84~~Discounted rate:$80USD/night
Hotel Service Fee: $4.99 per room per night
See Availability
Comfort Inn & Suites Santee I-95
221 Britain Street,
Santee, SC, 29142, US
0.92 mi from Santee, SC
3.92 stars rating. Good. 1706 reviews3.92 stars rating. Good. 1706 reviews
BOOK NOW AND SAVE 19%
Strikethrough Rate:~~$162~~Discounted rate:$131USD/night
See Availability
Econo Lodge
9112 Old Number 6 Hwy,
Santee, SC, 29142, US
1.32 mi from Santee, SC
3 stars rating. Fair. 167 reviews3 stars rating. Fair. 167 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$95~~Discounted rate:$91USD/night
See Availability
Econo Lodge
5971 West Jim Bilton Blvd.,
Saint George, SC, 29477, US
20.44 mi from Santee, SC
3.06 stars rating. 354 reviews3.06 stars rating. 354 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$69~~Discounted rate:$66USD/night
See Availability
Quality Inn Manning I-95
3031 Paxville Highway,
Manning, SC, 29102, US
21.09 mi from Santee, SC
3.97 stars rating. Good. 118 reviews3.97 stars rating. Good. 118 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$120~~Discounted rate:$114USD/night
See Availability
Suburban Studios
3671 Saint Matthews Road, Building B,
Orangeburg, SC, 29118, US
20.43 mi from Santee, SC
4.12 stars rating. Very Good. 81 reviews4.12 stars rating. Very Good. 81 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$91~~Discounted rate:$86USD/night
See Availability
Quality Inn & Suites
3671 Saint Matthews Road, Building A,
Orangeburg, SC, 29118, US
20.37 mi from Santee, SC
3.41 stars rating. Good. 1715 reviews3.41 stars rating. Good. 1715 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$139~~Discounted rate:$132USD/night
See Availability

Change your dates to book properties below.

Comfort Inn & Suites
746 Citadel Road,
Orangeburg, SC, 29118, US
20.26 mi from Santee, SC
3.92 stars rating. Good. 1590 reviews3.92 stars rating. Good. 1590 reviews
Sold outfor your selected dates
See Availability
Palmetto Inn
6137 Alex Harvin Hwy,
Manning, SC, 29102, US
16.71 mi from Santee, SC
No Reviews YetNo Reviews Yet
Coming soonStart booking Aug 02, 2025
See Availability
Sleep Inn
3689 St. Matthews Rd,
Orangeburg, SC, 29118, US
20.36 mi from Santee, SC
3.89 stars rating. Good. 1274 reviews3.89 stars rating. Good. 1274 reviews
Sold outfor your selected dates
See Availability

Other Santee searches

Boutique Hotels in Santee

Hotel Deals in Santee

Extended Stay Hotels in Santee

Pet Friendly Hotels in Santee

Top Rated Hotels in Santee

Good to know

Number of hotels

10 hotels in Santee

Highest Price

$132

Lowest Price

$66

Avg. rating

3.2 (7237 reviews)