3 of 8 hotels near Santee, SC match your filters

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Pet friendly

Pool

Quality Inn & Suites
8929 Old Number Six Highway,
Santee, SC, 29142, US
1.08 mi from Santee, SC
2.46 stars rating. Fair. 232 reviews2.46 stars rating. Fair. 232 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$84~~Discounted rate:$80USD/night
Hotel Service Fee: $4.99 per room per night
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Quality Inn & Suites
3671 Saint Matthews Road, Building A,
Orangeburg, SC, 29118, US
20.37 mi from Santee, SC
3.41 stars rating. Good. 1715 reviews3.41 stars rating. Good. 1715 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$109~~Discounted rate:$104USD/night
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Quality Inn Manning I-95
3031 Paxville Highway,
Manning, SC, 29102, US
21.09 mi from Santee, SC
3.97 stars rating. Good. 118 reviews3.97 stars rating. Good. 118 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$120~~Discounted rate:$114USD/night
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Below are additional hotels in the area that do not match your exact search criteria.

Comfort Inn & Suites Santee I-95
221 Britain Street,
Santee, SC, 29142, US
0.92 mi from Santee, SC
3.92 stars rating. Good. 1707 reviews3.92 stars rating. Good. 1707 reviews
BOOK NOW AND SAVE 19%
Strikethrough Rate:~~$162~~Discounted rate:$131USD/night
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Econo Lodge
9112 Old Number 6 Hwy,
Santee, SC, 29142, US
1.32 mi from Santee, SC
3 stars rating. Fair. 167 reviews3 stars rating. Fair. 167 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$89~~Discounted rate:$85USD/night
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Econo Lodge
5971 West Jim Bilton Blvd.,
Saint George, SC, 29477, US
20.44 mi from Santee, SC
3.06 stars rating. 354 reviews3.06 stars rating. 354 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$69~~Discounted rate:$66USD/night
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Suburban Studios
3671 Saint Matthews Road, Building B,
Orangeburg, SC, 29118, US
20.43 mi from Santee, SC
4.12 stars rating. Very Good. 81 reviews4.12 stars rating. Very Good. 81 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$91~~Discounted rate:$86USD/night
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Comfort Inn & Suites
746 Citadel Road,
Orangeburg, SC, 29118, US
20.26 mi from Santee, SC
3.92 stars rating. Good. 1590 reviews3.92 stars rating. Good. 1590 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$189~~Discounted rate:$180USD/night
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Palmetto Inn
6137 Alex Harvin Hwy,
Manning, SC, 29102, US
16.71 mi from Santee, SC
No Reviews YetNo Reviews Yet
Coming soonStart booking Aug 02, 2025
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Sleep Inn
3689 St. Matthews Rd,
Orangeburg, SC, 29118, US
20.36 mi from Santee, SC
3.89 stars rating. Good. 1274 reviews3.89 stars rating. Good. 1274 reviews
Sold outfor your selected dates
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Good to know

Number of hotels

3 of 10 hotels in Santee

Highest Price

$180

Lowest Price

$66

Avg. rating

3.2 (7238 reviews)