Hotels near U.S. Route 66, Missouri in MO – Choice Hotels

AWARD WINNER
Quality Inn Joplin I-44
3325 Arizona Avenue,
Joplin, MO, 64804, US
4.24 mi from U.S. Rte 66, Joplin, MO, USA
4.05 stars rating. Very Good. 1171 reviews4.05 stars rating. Very Good. 1171 reviews
$91USD/night
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Sleep Inn South Joplin
4100 Missouri 43,
Joplin, MO, 64804, US
5.4 mi from U.S. Rte 66, Joplin, MO, USA
4.33 stars rating. Excellent. 987 reviews4.33 stars rating. Excellent. 987 reviews
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Strikethrough Rate:~~$109~~Discounted rate:$98USD/night
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Econo Lodge Inn & Suites Joplin
3510 South Range Line Rd,
Joplin, MO, 64804, US
4.41 mi from U.S. Rte 66, Joplin, MO, USA
3.24 stars rating. Good. 1029 reviews3.24 stars rating. Good. 1029 reviews
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Strikethrough Rate:~~$84~~Discounted rate:$76USD/night
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AWARD WINNER
Sleep Inn & Suites Webb City
221 S East Street,
Webb City, MO, 64870, US
6.37 mi from U.S. Rte 66, Joplin, MO, USA
4.74 stars rating. Exceptional. 650 reviews4.74 stars rating. Exceptional. 650 reviews
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Strikethrough Rate:~~$151~~Discounted rate:$136USD/night
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Quality Inn & Suites Carthage near Precious Moments Chapel
2701 Hazel St.,
Carthage, MO, 64836, US
13.08 mi from U.S. Rte 66, Joplin, MO, USA
3.31 stars rating. Good. 1098 reviews3.31 stars rating. Good. 1098 reviews
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Strikethrough Rate:~~$89~~Discounted rate:$74USD/night
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Comfort Inn & Suites Pittsburg KS
4009 Parkview Dr.,
Pittsburg, KS, 66762-2305, US
26.23 mi from U.S. Rte 66, Joplin, MO, USA
4.13 stars rating. Very Good. 1226 reviews4.13 stars rating. Very Good. 1226 reviews
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Strikethrough Rate:~~$124~~Discounted rate:$112USD/night
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NEW TO CHOICE
Comfort Inn & Suites
509 Henley St,
Miami, OK, 74354, US
22.61 mi from U.S. Rte 66, Joplin, MO, USA
No Reviews YetNo Reviews Yet
Coming soonStart booking Dec 31, 2025
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NEW TO CHOICE
Quality Inn Neosho
3085 Gardner-Edgewood Dr,
Neosho, MO, 64850, US
19.09 mi from U.S. Rte 66, Joplin, MO, USA
No Reviews YetNo Reviews Yet
Coming soonStart booking Feb 01, 2026
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Good to know

Number of hotels

8 hotels in Joplin

Highest Price

$136

Lowest Price

$74

Avg. rating

3.0 (6161 reviews)