Hotel Deals & Discounts in Clayton, MO | Choice Hotels

MainStay Suites St. Louis - Galleria
8011 Galleria Pkwy,
St. Louis, MO, 63117, US
1.92 km from Clayton, MO, USA
3.23 stars rating. Good. 164 reviews3.23 stars rating. Good. 164 reviews
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Strikethrough Rate:~~$139~~Discounted rate:$116USD/night
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Comfort Inn St. Louis - Westport Event Center
12031 Lackland Rd.,
Saint Louis, MO, 63146, US
10.72 km from Clayton, MO, USA
3.57 stars rating. Good. 3071 reviews3.57 stars rating. Good. 3071 reviews
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Strikethrough Rate:~~$95~~Discounted rate:$84USD/night
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Quality Inn Airport
10232 Natural Bridge Rd.,
Saint Louis, MO, 63134, US
9.69 km from Clayton, MO, USA
3.27 stars rating. Good. 3021 reviews3.27 stars rating. Good. 3021 reviews
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Strikethrough Rate:~~$82~~Discounted rate:$76USD/night
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Comfort Inn & Suites St. Louis-Hazelwood
7133 Douglas Palmer Place,
Hazelwood, MO, 63042, US
14.48 km from Clayton, MO, USA
4.12 stars rating. Very Good. 1974 reviews4.12 stars rating. Very Good. 1974 reviews
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Strikethrough Rate:~~$95~~Discounted rate:$84USD/night
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Quality Inn Florissant-St. Louis
55 Dunn Road,
Florissant, MO, 63031, US
14.02 km from Clayton, MO, USA
3.42 stars rating. Good. 1442 reviews3.42 stars rating. Good. 1442 reviews
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Strikethrough Rate:~~$69~~Discounted rate:$64USD/night
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Comfort Inn St. Louis Airport
11225 Lone Eagle Dr., Building A,
Bridgeton, MO, 63044, US
11.43 km from Clayton, MO, USA
4.07 stars rating. Very Good. 175 reviews4.07 stars rating. Very Good. 175 reviews
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Strikethrough Rate:~~$127~~Discounted rate:$106USD/night
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Comfort Suites St. Louis - Sunset Hills
3654 S. Lindbergh Blvd.,
Saint Louis, MO, 63127, US
12.37 km from Clayton, MO, USA
4.71 stars rating. Exceptional. 1824 reviews4.71 stars rating. Exceptional. 1824 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$111USD/night
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Comfort Inn & Suites
2625 Lafayette Ave,
Saint Louis, MO, 63104-2011, US
10.69 km from Clayton, MO, USA
3.8 stars rating. Good. 91 reviews3.8 stars rating. Good. 91 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$111USD/night
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MainStay Suites St. Louis Airport
11225 Lone Eagle Dr., Building B,
Bridgeton, MO, 63044, US
11.47 km from Clayton, MO, USA
3.93 stars rating. Good. 234 reviews3.93 stars rating. Good. 234 reviews
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Strikethrough Rate:~~$116~~Discounted rate:$97USD/night
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Quality Inn & Suites near St. Louis and I-255
1607 Pontiac Drive,
Cahokia, IL, 62206, US
18.3 km from Clayton, MO, USA
3.54 stars rating. Good. 1344 reviews3.54 stars rating. Good. 1344 reviews
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Strikethrough Rate:~~$88~~Discounted rate:$82USD/night
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Sleep Inn O'Fallon near I-64
140 Venita Drive,
O Fallon, IL, 62269, US
35.19 km from Clayton, MO, USA
3.39 stars rating. Good. 1320 reviews3.39 stars rating. Good. 1320 reviews
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Strikethrough Rate:~~$56~~Discounted rate:$49USD/night
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Country Inn & Suites by Radisson, St. Charles Historic District
1190 South Main Street,
Saint Charles, MO, 63301, US
18.75 km from Clayton, MO, USA
4.65 stars rating. Exceptional. 559 reviews4.65 stars rating. Exceptional. 559 reviews
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Strikethrough Rate:~~$154~~Discounted rate:$143USD/night
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River City Casino & Hotel
777 River City Casino Boulevard,
Saint Louis, MO, 63125, US
14.64 km from Clayton, MO, USA
No Reviews YetNo Reviews Yet
$155USD/night
Fees included
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Comfort Suites St Charles-St Louis
1400 S. Fifth Street,
Saint Charles, MO, 63301, US
18.85 km from Clayton, MO, USA
4.03 stars rating. Very Good. 2060 reviews4.03 stars rating. Very Good. 2060 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$111USD/night
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Quality Inn & Suites Caseyville - St. Louis
2180 Patricia Dr.,
Caseyville, IL, 62232, US
25.59 km from Clayton, MO, USA
2.73 stars rating. Fair. 705 reviews2.73 stars rating. Fair. 705 reviews
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Strikethrough Rate:~~$76~~Discounted rate:$71USD/night
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Sleep Inn
150 Fountain Lakes Blvd.,
Saint Charles, MO, 63301, US
25.22 km from Clayton, MO, USA
3.08 stars rating. 1019 reviews3.08 stars rating. 1019 reviews
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Strikethrough Rate:~~$86~~Discounted rate:$80USD/night
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Comfort Inn & Suites Chesterfield - St. Louis
18375 Chesterfield Arpt. Rd.,
Chesterfield, MO, 63005, US
27.48 km from Clayton, MO, USA
3.92 stars rating. Good. 2438 reviews3.92 stars rating. Good. 2438 reviews
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Strikethrough Rate:~~$112~~Discounted rate:$96USD/night
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Quality Inn O'Fallon IL - St. Louis
1409 W US 50,
O Fallon, IL, 62269, US
34.01 km from Clayton, MO, USA
3.56 stars rating. Good. 921 reviews3.56 stars rating. Good. 921 reviews
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Strikethrough Rate:~~$74~~Discounted rate:$63USD/night
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Comfort Inn Alton near I-255
11 Crossroads Ct.,
Alton, IL, 62002, US
33.28 km from Clayton, MO, USA
3.66 stars rating. Good. 850 reviews3.66 stars rating. Good. 850 reviews
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Strikethrough Rate:~~$89~~Discounted rate:$80USD/night
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Country Inn & Suites by Radisson, St. Peters, MO
3877 Veterans Memorial Pkwy,
Saint Peters, MO, 63376, US
25.19 km from Clayton, MO, USA
4.13 stars rating. Very Good. 206 reviews4.13 stars rating. Very Good. 206 reviews
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Strikethrough Rate:~~$109~~Discounted rate:$101USD/night
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Econo Lodge Inn & Suites
3236 W. Chain of Rocks Road,
Granite City, IL, 62040, US
22.47 km from Clayton, MO, USA
3.44 stars rating. Good. 371 reviews3.44 stars rating. Good. 371 reviews
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Strikethrough Rate:~~$74~~Discounted rate:$69USD/night
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Comfort Inn Collinsville near St. Louis
8 Commerce Dr.,
Collinsville, IL, 62234, US
28.34 km from Clayton, MO, USA
4.19 stars rating. Very Good. 1911 reviews4.19 stars rating. Very Good. 1911 reviews
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Strikethrough Rate:~~$128~~Discounted rate:$104USD/night
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Comfort Inn & Suites St. Louis-O'Fallon
100 Comfort Inn Court,
O Fallon, MO, 63366, US
34.05 km from Clayton, MO, USA
3.68 stars rating. Good. 1860 reviews3.68 stars rating. Good. 1860 reviews
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Strikethrough Rate:~~$86~~Discounted rate:$78USD/night
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Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive,
O Fallon, MO, 63368, US
32.92 km from Clayton, MO, USA
4.23 stars rating. Excellent. 1213 reviews4.23 stars rating. Excellent. 1213 reviews
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Strikethrough Rate:~~$102~~Discounted rate:$87USD/night
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Comfort Suites Fairview Heights - St Louis
137 Ludwig Drive,
Fairview Heights, IL, 62208, US
30.27 km from Clayton, MO, USA
3.46 stars rating. Good. 1773 reviews3.46 stars rating. Good. 1773 reviews
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Strikethrough Rate:~~$94~~Discounted rate:$87USD/night
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Hollywood Casino St Louis
777 Casino Center Drive,
Maryland Heights, MO, 63043, US
17.1 km from Clayton, MO, USA
No Reviews YetNo Reviews Yet
$175USD/night
Fees included
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Econo Lodge Inn & Suites Fairview Heights - St. Louis
305 Salem Place,
Fairview Heights, IL, 62208, US
31.16 km from Clayton, MO, USA
3.74 stars rating. Good. 316 reviews3.74 stars rating. Good. 316 reviews
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Strikethrough Rate:~~$71~~Discounted rate:$63USD/night
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Country Inn & Suites by Radisson, Fairview Heights, IL
140 Ludwig Drive,
Fairview Heights, IL, 62208, US
30.29 km from Clayton, MO, USA
3.2 stars rating. Good. 217 reviews3.2 stars rating. Good. 217 reviews
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Strikethrough Rate:~~$102~~Discounted rate:$92USD/night
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Comfort Inn & Suites OFallon - St Louis Area
116 Regency Park,
O'Fallon, IL, 62269, US
35.18 km from Clayton, MO, USA
2.32 stars rating. Fair. 96 reviews2.32 stars rating. Fair. 96 reviews
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Strikethrough Rate:~~$89~~Discounted rate:$80USD/night
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Quality Inn Near Six Flags St. Louis
1400 West Osage St.,
Pacific, MO, 63069, US
40.91 km from Clayton, MO, USA
4 stars rating. Very Good. 653 reviews4 stars rating. Very Good. 653 reviews
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Strikethrough Rate:~~$106~~Discounted rate:$95USD/night
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Radisson Hotel Fairview Heights - St. Louis
319 Fountains Pkwy,
Fairview Heights, IL, 62208, US
31.21 km from Clayton, MO, USA
3.12 stars rating. Good. 131 reviews3.12 stars rating. Good. 131 reviews
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Strikethrough Rate:~~$104~~Discounted rate:$94USD/night
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Comfort Inn Edwardsville - St. Louis
3080 S. SR 157,
Edwardsville, IL, 62025, US
31.54 km from Clayton, MO, USA
4.17 stars rating. Very Good. 1362 reviews4.17 stars rating. Very Good. 1362 reviews
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Strikethrough Rate:~~$137~~Discounted rate:$123USD/night
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Comfort Inn Near Six Flags St. Louis
1320 Thornton St.,
Pacific, MO, 63069, US
40.77 km from Clayton, MO, USA
4.05 stars rating. Very Good. 1718 reviews4.05 stars rating. Very Good. 1718 reviews
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Strikethrough Rate:~~$120~~Discounted rate:$111USD/night
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The Great Rivers, an Ascend Collection Hotel
3559 College Avenue,
Alton, IL, 62002, US
33.4 km from Clayton, MO, USA
2.84 stars rating. Fair. 89 reviews2.84 stars rating. Fair. 89 reviews
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Strikethrough Rate:~~$115~~Discounted rate:$109USD/night
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Radisson Hotel St. Louis Downtown Convention Center
811 N 9th St,
St. Louis, MO, 63101, US
12.71 km from Clayton, MO, USA
No Reviews YetNo Reviews Yet
Coming soonStart booking 29 oct. 2026
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Hotel deals

35 hotels in Clayton

Highest Price

$175

Lowest Price

$49

Avg. rating

3.4 (35128 reviews)

Best Hotel Deal in Clayton

19% off