Book Sleep Hotels in Clayton, MO

Sleep Inn Saint Charles North
150 Fountain Lakes Blvd.,
Saint Charles, MO, 63301, US
15.67 mi from Clayton, MO, US
3.08 stars rating. Fair. 1047 reviews
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Strikethrough Rate:~~$104~~Discounted rate:$99USD/night
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Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive,
O Fallon, MO, 63368, US
20.46 mi from Clayton, MO, US
4.22 stars rating. Excellent. 1273 reviews
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Strikethrough Rate:~~$179~~Discounted rate:$153USD/night
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Sleep Inn O'Fallon near I-64
140 Venita Drive,
O Fallon, IL, 62269, US
21.87 mi from Clayton, MO, US
3.37 stars rating. Good. 1351 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$113USD/night
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AWARD WINNER
Comfort Suites St. Louis - Sunset Hills
3654 S. Lindbergh Blvd.,
Saint Louis, MO, 63127, US
7.69 mi from Clayton, MO, US
4.73 stars rating. Exceptional. 2025 reviews
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Strikethrough Rate:~~$199~~Discounted rate:$189USD/night
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Quality Inn Saint Louis Airport
10232 Natural Bridge Rd.,
Saint Louis, MO, 63134, US
6.02 mi from Clayton, MO, US
3.26 stars rating. Good. 3067 reviews
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Strikethrough Rate:~~$125~~Discounted rate:$119USD/night
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Quality Inn Florissant-St. Louis
55 Dunn Road,
Florissant, MO, 63031, US
8.71 mi from Clayton, MO, US
3.41 stars rating. Good. 1477 reviews
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Strikethrough Rate:~~$115~~Discounted rate:$109USD/night
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Comfort Inn & Suites Hazelwood - St. Louis
7133 Douglas Palmer Place,
Hazelwood, MO, 63042, US
9 mi from Clayton, MO, US
4.1 stars rating. Very Good. 2001 reviews
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Strikethrough Rate:~~$154~~Discounted rate:$146USD/night
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River City Casino & Hotel
777 River City Casino Boulevard,
Saint Louis, MO, 63125, US
9.1 mi from Clayton, MO, US
No Reviews Yet
$255USD/night
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AWARD WINNER
Country Inn & Suites by Radisson, St. Charles Historic District
1190 South Main Street,
Saint Charles, MO, 63301, US
11.65 mi from Clayton, MO, US
4.64 stars rating. Exceptional. 671 reviews
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Strikethrough Rate:~~$258~~Discounted rate:$245USD/night
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Comfort Suites St Charles-St Louis
1400 S. Fifth Street,
Saint Charles, MO, 63301, US
11.71 mi from Clayton, MO, US
4.02 stars rating. Very Good. 2096 reviews
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Strikethrough Rate:~~$220~~Discounted rate:$209USD/night
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Comfort Inn & Suites Chesterfield - St. Louis
18375 Chesterfield Arpt. Rd.,
Chesterfield, MO, 63005, US
17.07 mi from Clayton, MO, US
3.9 stars rating. Good. 2510 reviews
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Strikethrough Rate:~~$151~~Discounted rate:$137USD/night
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Country Inn & Suites by Radisson, St. Peters, MO
3877 Veterans Memorial Pkwy,
Saint Peters, MO, 63376, US
15.65 mi from Clayton, MO, US
4.05 stars rating. Very Good. 232 reviews
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Strikethrough Rate:~~$160~~Discounted rate:$152USD/night
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Quality Inn & Suites Caseyville - St. Louis
2180 Patricia Dr.,
Caseyville, IL, 62232, US
15.9 mi from Clayton, MO, US
2.7 stars rating. Fair. 717 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$113USD/night
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Comfort Inn Edwardsville - St. Louis
3080 S. SR 157,
Edwardsville, IL, 62025, US
19.6 mi from Clayton, MO, US
4.16 stars rating. Very Good. 1379 reviews
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Strikethrough Rate:~~$199~~Discounted rate:$179USD/night
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Comfort Suites Fairview Heights - St Louis
137 Ludwig Drive,
Fairview Heights, IL, 62208, US
18.81 mi from Clayton, MO, US
3.45 stars rating. Good. 1816 reviews
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Strikethrough Rate:~~$159~~Discounted rate:$143USD/night
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Quality Inn O'Fallon IL - St. Louis
1409 W US 50,
O Fallon, IL, 62269, US
21.13 mi from Clayton, MO, US
3.55 stars rating. Good. 947 reviews
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Strikethrough Rate:~~$109~~Discounted rate:$104USD/night
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Country Inn & Suites by Radisson, Fairview Heights, IL
140 Ludwig Drive,
Fairview Heights, IL, 62208, US
18.82 mi from Clayton, MO, US
3.15 stars rating. Good. 235 reviews
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Strikethrough Rate:~~$179~~Discounted rate:$161USD/night
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Quality Inn Pacific near Six Flags St. Louis
1400 West Osage St.,
Pacific, MO, 63069, US
25.42 mi from Clayton, MO, US
4 stars rating. Very Good. 664 reviews
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Strikethrough Rate:~~$139~~Discounted rate:$125USD/night
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Comfort Inn & Suites St. Louis-O'Fallon
8170 Veterans Memorial Pkwy,
O Fallon, MO, 63366, US
21.16 mi from Clayton, MO, US
3.68 stars rating. Good. 1922 reviews
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Strikethrough Rate:~~$190~~Discounted rate:$184USD/night
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Econo Lodge Inn & Suites Fairview Heights - St. Louis
305 Salem Place,
Fairview Heights, IL, 62208, US
19.36 mi from Clayton, MO, US
3.76 stars rating. Good. 322 reviews
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Strikethrough Rate:~~$115~~Discounted rate:$104USD/night
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Comfort Inn Near Six Flags St. Louis
1320 Thornton St.,
Pacific, MO, 63069, US
25.33 mi from Clayton, MO, US
4.06 stars rating. Very Good. 1780 reviews
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Strikethrough Rate:~~$159~~Discounted rate:$151USD/night
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MainStay Suites St. Louis - Galleria
8011 Galleria Pkwy,
St. Louis, MO, 63117, US
1.19 mi from Clayton, MO, US
3.17 stars rating. Good. 202 reviews
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MainStay Suites St. Louis Airport
11225 Lone Eagle Dr., Building B,
Bridgeton, MO, 63044, US
7.12 mi from Clayton, MO, US
3.92 stars rating. Good. 242 reviews
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Comfort Inn & Suites Saint Louis Lafayette Square
2625 Lafayette Ave,
Saint Louis, MO, 63104-2011, US
6.64 mi from Clayton, MO, US
3.78 stars rating. Good. 124 reviews
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Comfort Inn Alton near I-255
11 Crossroads Ct.,
Alton, IL, 62002, US
20.68 mi from Clayton, MO, US
3.65 stars rating. Good. 866 reviews
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Comfort Inn & Suites OFallon - St Louis Area
116 Regency Park,
O'Fallon, IL, 62269, US
21.86 mi from Clayton, MO, US
2.32 stars rating. Fair. 124 reviews
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NEW TO CHOICE
Radisson Hotel St. Louis Downtown Convention Center
811 N 9th St,
St. Louis, MO, 63101, US
7.9 mi from Clayton, MO, US
1.42 stars rating. Fair. 91 reviews
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Hollywood Casino St Louis
777 Casino Center Drive,
Maryland Heights, MO, 63043, US
10.63 mi from Clayton, MO, US
No Reviews Yet
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Comfort Inn St. Louis - Westport Event Center
12031 Lackland Rd.,
Saint Louis, MO, 63146, US
6.66 mi from Clayton, MO, US
3.55 stars rating. Good. 3113 reviews
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Radisson Hotel Fairview Heights - St. Louis
319 Fountains Pkwy,
Fairview Heights, IL, 62208, US
19.39 mi from Clayton, MO, US
3.54 stars rating. Good. 207 reviews
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Comfort Inn St. Louis Airport
11225 Lone Eagle Dr., Building A,
Bridgeton, MO, 63044, US
7.1 mi from Clayton, MO, US
4.06 stars rating. Very Good. 186 reviews
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The Great Rivers, an Ascend Collection Hotel
3559 College Avenue,
Alton, IL, 62002, US
20.75 mi from Clayton, MO, US
2.94 stars rating. Fair. 108 reviews
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Econo Lodge Inn & Suites Granite City - St. Louis
3236 W. Chain of Rocks Road,
Granite City, IL, 62040, US
13.96 mi from Clayton, MO, US
3.44 stars rating. Good. 392 reviews
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Comfort Inn Collinsville near St. Louis
8 Commerce Dr.,
Collinsville, IL, 62234, US
17.61 mi from Clayton, MO, US
4.2 stars rating. Excellent. 1971 reviews
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Quality Inn & Suites near St. Louis and I-255
1607 Pontiac Drive,
Cahokia, IL, 62206, US
11.37 mi from Clayton, MO, US
3.53 stars rating. Good. 1354 reviews
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Clayton hotels by brand

Ascend Hotels

Comfort Inn Hotels

Comfort Suites Hotels

Country Inn Suites Hotels

Good to know

Number of hotels

21 of 35 hotels in Clayton

Highest Price

$255

Lowest Price

$99

Avg. rating

3 hotels near Clayton, MO, US match your filters

Below are additional hotels in the area that do not match your exact search criteria.

Change your dates to book properties below.

Other Clayton searches

Clayton hotels by brand

Good to know

21 of 35 hotels in Clayton

$255

$99

3.4 (36512 reviews)