Hotels in Clayton, MO – Choice Hotels

Comfort Inn St. Louis Airport
11225 Lone Eagle Dr., Building A,
Bridgeton, MO, 63044, US
8.27 mi from Clayton, MO, US
4.07 stars rating. Very Good. 190 reviews
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Strikethrough Rate:~~$154~~Discounted rate:$125USD/night
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MainStay Suites St. Louis - Galleria
8011 Galleria Pkwy,
St. Louis, MO, 63117, US
1.12 mi from Clayton, MO, US
3.15 stars rating. Good. 210 reviews
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Strikethrough Rate:~~$169~~Discounted rate:$161USD/night
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Quality Inn Florissant-St. Louis
55 Dunn Road,
Florissant, MO, 63031, US
9.66 mi from Clayton, MO, US
3.41 stars rating. Good. 1480 reviews
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Strikethrough Rate:~~$94~~Discounted rate:$89USD/night
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Comfort Inn & Suites Hazelwood - St. Louis
7133 Douglas Palmer Place,
Hazelwood, MO, 63042, US
10.02 mi from Clayton, MO, US
4.1 stars rating. Very Good. 2005 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$113USD/night
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Quality Inn Saint Louis Airport
10232 Natural Bridge Rd.,
Saint Louis, MO, 63134, US
7.09 mi from Clayton, MO, US
3.26 stars rating. Good. 3079 reviews
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Strikethrough Rate:~~$95~~Discounted rate:$90USD/night
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NEW TO CHOICE
Radisson Hotel St. Louis Downtown Convention Center
811 N 9th St,
St. Louis, MO, 63101, US
7.08 mi from Clayton, MO, US
1.43 stars rating. Fair. 117 reviews
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Strikethrough Rate:~~$209~~Discounted rate:$199USD/night
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Comfort Inn & Suites Saint Louis Lafayette Square
2625 Lafayette Ave,
Saint Louis, MO, 63104-2011, US
5.65 mi from Clayton, MO, US
3.79 stars rating. Good. 126 reviews
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Strikethrough Rate:~~$249~~Discounted rate:$232USD/night
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AWARD WINNER
Country Inn & Suites by Radisson, St. Charles Historic District
1190 South Main Street,
Saint Charles, MO, 63301, US
12.83 mi from Clayton, MO, US
4.64 stars rating. Exceptional. 685 reviews
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Strikethrough Rate:~~$239~~Discounted rate:$227USD/night
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Quality Inn & Suites near St. Louis and I-255
1607 Pontiac Drive,
Cahokia, IL, 62206, US
10.24 mi from Clayton, MO, US
3.52 stars rating. Good. 1360 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$123USD/night
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Comfort Suites St Charles-St Louis
1400 S. Fifth Street,
Saint Charles, MO, 63301, US
12.89 mi from Clayton, MO, US
4.02 stars rating. Very Good. 2107 reviews
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Strikethrough Rate:~~$219~~Discounted rate:$208USD/night
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Hollywood Casino St Louis
777 Casino Center Drive,
Maryland Heights, MO, 63043, US
11.8 mi from Clayton, MO, US
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Strikethrough Rate:~~$245~~Discounted rate:$211USD/night
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Country Inn & Suites by Radisson, St. Peters, MO
3877 Veterans Memorial Pkwy,
Saint Peters, MO, 63376, US
16.81 mi from Clayton, MO, US
4.05 stars rating. Very Good. 235 reviews
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Strikethrough Rate:~~$165~~Discounted rate:$157USD/night
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Sleep Inn Saint Charles North
150 Fountain Lakes Blvd.,
Saint Charles, MO, 63301, US
16.86 mi from Clayton, MO, US
3.08 stars rating. Fair. 1048 reviews
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Strikethrough Rate:~~$104~~Discounted rate:$99USD/night
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Econo Lodge Inn & Suites Granite City - St. Louis
3236 W. Chain of Rocks Road,
Granite City, IL, 62040, US
13.91 mi from Clayton, MO, US
3.45 stars rating. Good. 394 reviews
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Strikethrough Rate:~~$84~~Discounted rate:$80USD/night
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Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive,
O Fallon, MO, 63368, US
21.4 mi from Clayton, MO, US
4.23 stars rating. Excellent. 1279 reviews
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Strikethrough Rate:~~$154~~Discounted rate:$132USD/night
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Comfort Inn & Suites Chesterfield - St. Louis
18375 Chesterfield Arpt. Rd.,
Chesterfield, MO, 63005, US
17.92 mi from Clayton, MO, US
3.89 stars rating. Good. 2519 reviews
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Strikethrough Rate:~~$173~~Discounted rate:$156USD/night
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Quality Inn & Suites Caseyville - St. Louis
2180 Patricia Dr.,
Caseyville, IL, 62232, US
15.04 mi from Clayton, MO, US
2.7 stars rating. Fair. 721 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$123USD/night
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Country Inn & Suites by Radisson, Fairview Heights, IL
140 Ludwig Drive,
Fairview Heights, IL, 62208, US
17.95 mi from Clayton, MO, US
3.16 stars rating. Good. 238 reviews
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Strikethrough Rate:~~$189~~Discounted rate:$170USD/night
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Comfort Suites Fairview Heights - St Louis
137 Ludwig Drive,
Fairview Heights, IL, 62208, US
17.93 mi from Clayton, MO, US
3.45 stars rating. Good. 1820 reviews
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Strikethrough Rate:~~$194~~Discounted rate:$175USD/night
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Comfort Inn & Suites St. Louis-O'Fallon
8170 Veterans Memorial Pkwy,
O Fallon, MO, 63366, US
22.27 mi from Clayton, MO, US
3.68 stars rating. Good. 1926 reviews
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Strikethrough Rate:~~$139~~Discounted rate:$135USD/night
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Quality Inn Pacific near Six Flags St. Louis
1400 West Osage St.,
Pacific, MO, 63069, US
25.7 mi from Clayton, MO, US
4.01 stars rating. Very Good. 669 reviews
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Strikethrough Rate:~~$139~~Discounted rate:$125USD/night
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Quality Inn O'Fallon IL - St. Louis
1409 W US 50,
O Fallon, IL, 62269, US
20.24 mi from Clayton, MO, US
3.55 stars rating. Good. 954 reviews
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Strikethrough Rate:~~$137~~Discounted rate:$130USD/night
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Comfort Inn & Suites OFallon - St Louis Area
116 Regency Park,
O'Fallon, IL, 62269, US
20.97 mi from Clayton, MO, US
2.34 stars rating. Fair. 127 reviews
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Strikethrough Rate:~~$159~~Discounted rate:$143USD/night
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Sleep Inn O'Fallon near I-64
140 Venita Drive,
O Fallon, IL, 62269, US
20.99 mi from Clayton, MO, US
3.36 stars rating. Good. 1354 reviews
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Strikethrough Rate:~~$139~~Discounted rate:$132USD/night
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The Great Rivers, an Ascend Collection Hotel
3559 College Avenue,
Alton, IL, 62002, US
21.17 mi from Clayton, MO, US
2.89 stars rating. Fair. 113 reviews
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Strikethrough Rate:~~$150~~Discounted rate:$143USD/night
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Radisson Hotel Fairview Heights - St. Louis
319 Fountains Pkwy,
Fairview Heights, IL, 62208, US
18.53 mi from Clayton, MO, US
3.51 stars rating. Good. 220 reviews
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Strikethrough Rate:~~$209~~Discounted rate:$199USD/night
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Comfort Inn Near Six Flags St. Louis
1320 Thornton St.,
Pacific, MO, 63069, US
25.62 mi from Clayton, MO, US
4.06 stars rating. Very Good. 1786 reviews
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Strikethrough Rate:~~$176~~Discounted rate:$159USD/night
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Econo Lodge Inn & Suites Fairview Heights - St. Louis
305 Salem Place,
Fairview Heights, IL, 62208, US
18.49 mi from Clayton, MO, US
3.76 stars rating. Good. 326 reviews
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Strikethrough Rate:~~$150~~Discounted rate:$135USD/night
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MainStay Suites St. Louis Airport
11225 Lone Eagle Dr., Building B,
Bridgeton, MO, 63044, US
8.29 mi from Clayton, MO, US
3.92 stars rating. Good. 244 reviews
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AWARD WINNER
Comfort Suites St. Louis - Sunset Hills
3654 S. Lindbergh Blvd.,
Saint Louis, MO, 63127, US
7.32 mi from Clayton, MO, US
4.73 stars rating. Exceptional. 2047 reviews
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Comfort Inn Alton near I-255
11 Crossroads Ct.,
Alton, IL, 62002, US
21.09 mi from Clayton, MO, US
3.64 stars rating. Good. 867 reviews
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River City Casino & Hotel
777 River City Casino Boulevard,
Saint Louis, MO, 63125, US
7.95 mi from Clayton, MO, US
No Reviews Yet
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Comfort Inn Collinsville near St. Louis
8 Commerce Dr.,
Collinsville, IL, 62234, US
17.03 mi from Clayton, MO, US
4.2 stars rating. Excellent. 1979 reviews
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Comfort Inn Edwardsville - St. Louis
3080 S. SR 157,
Edwardsville, IL, 62025, US
19.33 mi from Clayton, MO, US
4.16 stars rating. Very Good. 1384 reviews
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Discover the Suburban Elegance of Clayton, Missouri

Clayton, an affluent suburb of St. Louis, offers visitors sophisticated urban amenities combined with beautiful residential neighborhoods and excellent cultural attractions. The community features upscale shopping, fine dining, and well-maintained parks that provide peaceful retreats from city life. Visitors can explore the Shaw Park area, enjoy cultural events, or easily access nearby St. Louis attractions including museums, sports venues, and entertainment districts. The area's blend of suburban charm and urban convenience creates perfect destinations for both relaxation and exploration. For accommodations, Choice Hotels provides convenient access to Clayton's attractions and greater St. Louis area amenities.