34 hotels near Clayton, MO, USA

34 hotels near Clayton, MO, USA

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    • AWARD WINNER

      Comfort Suites St. Louis - Sunset Hills

      3654 S. Lindbergh Blvd.,
      Saint Louis, MO, 63127, US
      4.73 stars rating. Exceptional. 2086 reviews

      BOOK NOW AND SAVE 7%

      Strikethrough Rate:$119Discounted rate:$111USD/night
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    • Comfort Inn St. Louis Airport

      11225 Lone Eagle Dr., Building A,
      Bridgeton, MO, 63044, US
      4.06 stars rating. Very Good. 193 reviews

      BOOK NOW AND SAVE 19%

      Strikethrough Rate:$106Discounted rate:$86USD/night
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    • MainStay Suites St. Louis - Galleria

      8011 Galleria Pkwy,
      St. Louis, MO, 63117, US
      3.12 stars rating. Good. 216 reviews

      BOOK NOW AND SAVE 7%

      Strikethrough Rate:$129Discounted rate:$120USD/night
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    • Comfort Inn & Suites Hazelwood - St. Louis

      7133 Douglas Palmer Place,
      Hazelwood, MO, 63042, US
      4.09 stars rating. Very Good. 2017 reviews

      BOOK NOW AND SAVE 12%

      Strikethrough Rate:$92Discounted rate:$81USD/night
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    • Quality Inn Saint Louis Airport

      10232 Natural Bridge Rd.,
      Saint Louis, MO, 63134, US
      3.26 stars rating. Good. 3088 reviews

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      Strikethrough Rate:$94Discounted rate:$87USD/night
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    • NEW TO CHOICE

      Comfort Inn & Suites Saint Louis Lafayette Square

      2625 Lafayette Ave,
      Saint Louis, MO, 63104-2011, US
      3.81 stars rating. Good. 130 reviews

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      Strikethrough Rate:$149Discounted rate:$134USD/night
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    • Quality Inn Florissant-St. Louis

      55 Dunn Road,
      Florissant, MO, 63031, US
      3.41 stars rating. Good. 1485 reviews

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      Strikethrough Rate:$84Discounted rate:$78USD/night
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    • River City Casino & Hotel

      777 River City Casino Boulevard,
      Saint Louis, MO, 63125, US
      No Reviews Yet

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      Strikethrough Rate:$165Discounted rate:$135USD/night
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    • Comfort Suites St Charles-St Louis

      1400 S. Fifth Street,
      Saint Charles, MO, 63301, US
      4.02 stars rating. Very Good. 2124 reviews

      BOOK NOW AND SAVE 7%

      Strikethrough Rate:$127Discounted rate:$118USD/night
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    • Quality Inn & Suites near St. Louis and I-255

      1607 Pontiac Drive,
      Cahokia, IL, 62206, US
      3.52 stars rating. Good. 1362 reviews

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      Strikethrough Rate:$93Discounted rate:$86USD/night
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    • MainStay Suites St. Louis Airport

      11225 Lone Eagle Dr., Building B,
      Bridgeton, MO, 63044, US
      3.93 stars rating. Good. 245 reviews

      BOOK NOW AND SAVE 16%

      Strikethrough Rate:$116Discounted rate:$97USD/night
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    • NEW TO CHOICE

      Radisson Hotel St. Louis Downtown Convention Center

      811 N 9th St,
      St. Louis, MO, 63101, US
      1.44 stars rating. Fair. 124 reviews

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      Strikethrough Rate:$130Discounted rate:$124USD/night
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    • Hollywood Casino St Louis

      777 Casino Center Drive,
      Maryland Heights, MO, 63043, US
      No Reviews Yet

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      Strikethrough Rate:$155Discounted rate:$127USD/night
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    • AWARD WINNER

      Country Inn & Suites by Radisson, St. Charles Historic District

      1190 South Main Street,
      Saint Charles, MO, 63301, US
      4.64 stars rating. Exceptional. 693 reviews

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      Strikethrough Rate:$204Discounted rate:$189USD/night
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    • Comfort Inn & Suites Chesterfield - St. Louis

      18375 Chesterfield Arpt. Rd.,
      Chesterfield, MO, 63005, US
      3.89 stars rating. Good. 2526 reviews

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      Strikethrough Rate:$101Discounted rate:$91USD/night
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    • Econo Lodge Inn & Suites Granite City - St. Louis

      3236 W. Chain of Rocks Road,
      Granite City, IL, 62040, US
      3.46 stars rating. Good. 397 reviews

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      Strikethrough Rate:$69Discounted rate:$64USD/night
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    • Country Inn & Suites by Radisson, St. Peters, MO

      3877 Veterans Memorial Pkwy,
      Saint Peters, MO, 63376, US
      4.05 stars rating. Very Good. 241 reviews

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      Strikethrough Rate:$102Discounted rate:$95USD/night
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    • Comfort Inn Collinsville near St. Louis

      8 Commerce Dr.,
      Collinsville, IL, 62234, US
      4.2 stars rating. Excellent. 1991 reviews

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      Strikethrough Rate:$136Discounted rate:$110USD/night
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    • NEW TO CHOICE

      Radisson Hotel Fairview Heights - St. Louis

      319 Fountains Pkwy,
      Fairview Heights, IL, 62208, US
      3.52 stars rating. Good. 230 reviews

      BOOK NOW AND SAVE 5%

      Strikethrough Rate:$90Discounted rate:$86USD/night
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    • Sleep Inn & Suites O'Fallon MO - Technology Drive

      1147 Technology Drive,
      O Fallon, MO, 63368, US
      4.23 stars rating. Excellent. 1289 reviews

      BOOK NOW AND SAVE 19%

      Strikethrough Rate:$104Discounted rate:$84USD/night
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    • Quality Inn & Suites Caseyville - St. Louis

      2180 Patricia Dr.,
      Caseyville, IL, 62232, US
      2.7 stars rating. Fair. 723 reviews

      BOOK NOW AND SAVE 7%

      Strikethrough Rate:$73Discounted rate:$67USD/night
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    • Comfort Suites Fairview Heights - St Louis

      137 Ludwig Drive,
      Fairview Heights, IL, 62208, US
      3.44 stars rating. Good. 1831 reviews

      BOOK NOW AND SAVE 10%

      Strikethrough Rate:$79Discounted rate:$71USD/night
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    • Sleep Inn Saint Charles North

      150 Fountain Lakes Blvd.,
      Saint Charles, MO, 63301, US
      3.08 stars rating. Fair. 1054 reviews

      BOOK NOW AND SAVE 7%

      Strikethrough Rate:$90Discounted rate:$83USD/night
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    • Country Inn & Suites by Radisson, Fairview Heights, IL

      140 Ludwig Drive,
      Fairview Heights, IL, 62208, US
      3.17 stars rating. Good. 246 reviews

      BOOK NOW AND SAVE 10%

      Strikethrough Rate:$92Discounted rate:$83USD/night
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    • Comfort Inn Edwardsville - St. Louis

      3080 S. SR 157,
      Edwardsville, IL, 62025, US
      4.16 stars rating. Very Good. 1391 reviews

      BOOK NOW AND SAVE 10%

      Strikethrough Rate:$115Discounted rate:$104USD/night
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    • Quality Inn O'Fallon IL - St. Louis

      1409 W US 50,
      O Fallon, IL, 62269, US
      3.54 stars rating. Good. 963 reviews

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      Strikethrough Rate:$75Discounted rate:$71USD/night
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    • Comfort Inn Alton near I-255

      11 Crossroads Ct.,
      Alton, IL, 62002, US
      3.64 stars rating. Good. 872 reviews

      BOOK NOW AND SAVE 10%

      Strikethrough Rate:$105Discounted rate:$95USD/night
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    • Econo Lodge Inn & Suites Fairview Heights - St. Louis

      305 Salem Place,
      Fairview Heights, IL, 62208, US
      3.78 stars rating. Good. 333 reviews

      BOOK NOW AND SAVE 10%

      Strikethrough Rate:$75Discounted rate:$68USD/night
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    • Comfort Inn & Suites St. Louis-O'Fallon

      8170 Veterans Memorial Pkwy,
      O Fallon, MO, 63366, US
      3.67 stars rating. Good. 1940 reviews

      BOOK NOW AND SAVE 10%

      Strikethrough Rate:$105Discounted rate:$94USD/night
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    • Sleep Inn O'Fallon near I-64

      140 Venita Drive,
      O Fallon, IL, 62269, US
      3.36 stars rating. Good. 1359 reviews

      BOOK NOW AND SAVE 7%

      Strikethrough Rate:$79Discounted rate:$73USD/night
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    • Comfort Inn & Suites OFallon - St Louis Area

      116 Regency Park,
      O'Fallon, IL, 62269, US
      2.36 stars rating. Fair. 132 reviews

      BOOK NOW AND SAVE 10%

      Strikethrough Rate:$94Discounted rate:$85USD/night
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    • Quality Inn Pacific near Six Flags St. Louis

      1400 West Osage St.,
      Pacific, MO, 63069, US
      4 stars rating. Very Good. 673 reviews

      BOOK NOW AND SAVE 10%

      Strikethrough Rate:$119Discounted rate:$107USD/night
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    • Comfort Inn Near Six Flags St. Louis

      1320 Thornton St.,
      Pacific, MO, 63069, US
      4.06 stars rating. Very Good. 1795 reviews

      BOOK NOW AND SAVE 10%

      Strikethrough Rate:$135Discounted rate:$121USD/night
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    • NEW TO CHOICE

      The Great Rivers, an Ascend Collection Hotel

      3559 College Avenue,
      Alton, IL, 62002, US
      2.91 stars rating. Fair. 115 reviews

      BOOK NOW AND SAVE 5%

      Strikethrough Rate:$133Discounted rate:$127USD/night
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    Discover the Suburban Elegance of Clayton, Missouri

    Clayton, an affluent suburb of St. Louis, offers visitors sophisticated urban amenities combined with beautiful residential neighborhoods and excellent cultural attractions. The community features upscale shopping, fine dining, and well-maintained parks that provide peaceful retreats from city life. Visitors can explore the Shaw Park area, enjoy cultural events, or easily access nearby St. Louis attractions including museums, sports venues, and entertainment districts. The area's blend of suburban charm and urban convenience creates perfect destinations for both relaxation and exploration. For accommodations, Choice Hotels provides convenient access to Clayton's attractions and greater St. Louis area amenities.

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    Clayton hotels by brand

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    Number of hotels

    34 hotels in Clayton

    Highest Price

    $189

    Lowest Price

    $64

    Avg. rating

    3.6 (33864 reviews)