Book Boutique Hotels in Florence, SC

Suburban Studios Florence - Darlington
1914 West Lucas Street, I-95 & US 52,
Florence, SC, 29501, US
4.57 km from Florence, SC
2.92 stars rating. Fair. 1323 reviews2.92 stars rating. Fair. 1323 reviews
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Strikethrough Rate:~~$55~~Discounted rate:$51USD/night
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Clarion Inn & Suites
1819 West Lucas Street, Building A,
Florence, SC, 29501, US
4.43 km from Florence, SC
1.93 stars rating. Fair. 194 reviews1.93 stars rating. Fair. 194 reviews
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Strikethrough Rate:~~$69~~Discounted rate:$65USD/night
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Comfort Suites Florence I-95
2120 West Lucas Street,
Florence, SC, 29501, US
5.34 km from Florence, SC
4.27 stars rating. Excellent. 2611 reviews4.27 stars rating. Excellent. 2611 reviews
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Strikethrough Rate:~~$119~~Discounted rate:$113USD/night
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Sleep Inn Florence North
1833 Florence Park Dr., I-95 & US 52,
Florence, SC, 29501, US
5.32 km from Florence, SC
3.74 stars rating. Good. 1974 reviews3.74 stars rating. Good. 1974 reviews
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Strikethrough Rate:~~$80~~Discounted rate:$74USD/night
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Comfort Inn & Suites
527 Woody Jones Blvd.,
Florence, SC, 29501, US
6.28 km from Florence, SC
4.5 stars rating. Excellent. 1172 reviews4.5 stars rating. Excellent. 1172 reviews
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Strikethrough Rate:~~$124~~Discounted rate:$118USD/night
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Quality Inn & Suites Florence Civic Center
150 Dunbarton Drive,
Florence, SC, 29501, US
6.82 km from Florence, SC
3.95 stars rating. Good. 1742 reviews3.95 stars rating. Good. 1742 reviews
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Strikethrough Rate:~~$102~~Discounted rate:$95USD/night
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Econo Lodge
1920 West Lucas Street,
Florence, SC, 29501, US
4.6 km from Florence, SC
2.87 stars rating. Fair. 1357 reviews2.87 stars rating. Fair. 1357 reviews
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Strikethrough Rate:~~$63~~Discounted rate:$56USD/night
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MainStay Suites
1819 West Lucas Street, Building B,
Florence, SC, 29501, US
4.48 km from Florence, SC
1.95 stars rating. Fair. 57 reviews1.95 stars rating. Fair. 57 reviews
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Strikethrough Rate:~~$72~~Discounted rate:$67USD/night
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Park Inn by Radisson Florence, SC
1729 Mandeville Road,
Florence, SC, 29501, US
4.93 km from Florence, SC
4.27 stars rating. Excellent. 344 reviews4.27 stars rating. Excellent. 344 reviews
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Strikethrough Rate:~~$111~~Discounted rate:$105USD/night
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Quality Inn
903 South Fifth Street,
Hartsville, SC, 29550, US
33.19 km from Florence, SC
2.95 stars rating. Fair. 394 reviews2.95 stars rating. Fair. 394 reviews
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Strikethrough Rate:~~$78~~Discounted rate:$72USD/night
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Quality Inn & Suites
202 North Ron McNair Blvd.,
Lake City, SC, 29560, US
35.49 km from Florence, SC
3.32 stars rating. Good. 97 reviews3.32 stars rating. Good. 97 reviews
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Strikethrough Rate:~~$145~~Discounted rate:$135USD/night
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Rodeway Inn
415 S. Irby St.,
Florence, SC, 29501, US
0.75 km from Florence, SC
No Reviews YetNo Reviews Yet
Coming soonStart booking Sep 30, 2025
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Good to know

Boutique hotels

12 hotels in Florence

Highest Price

$135

Lowest Price

$51

Avg. rating

11 Boutique hotels near Florence, SC

Suburban Studios Florence - Darlington

Clarion Inn & Suites

Comfort Suites Florence I-95

Sleep Inn Florence North

Comfort Inn & Suites

Quality Inn & Suites Florence Civic Center

Econo Lodge

MainStay Suites

Park Inn by Radisson Florence, SC

Quality Inn

Quality Inn & Suites

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Rodeway Inn

Other Florence searches

Good to know

12 hotels in Florence

$135

$51

3.1 (11265 reviews)