Book Quality Hotels in Santee, SC - Choice Hotels

3 of 9 hotels near Santee, SC match your filters

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Pet friendly

Pool

Quality Inn & Suites
8929 Old Number Six Highway,
Santee, SC, 29142, US
1.08 mi from Santee, SC
2.46 stars rating. Fair. 232 reviews2.46 stars rating. Fair. 232 reviews
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Strikethrough Rate:~~$84~~Discounted rate:$80USD/night
Hotel Service Fee: $5 per room per night
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Quality Inn & Suites
3671 Saint Matthews Road, Building A,
Orangeburg, SC, 29118, US
20.37 mi from Santee, SC
3.41 stars rating. Good. 1714 reviews3.41 stars rating. Good. 1714 reviews
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Strikethrough Rate:~~$84~~Discounted rate:$80USD/night
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Quality Inn Manning I-95
3031 Paxville Highway,
Manning, SC, 29102, US
21.09 mi from Santee, SC
3.99 stars rating. Good. 117 reviews3.99 stars rating. Good. 117 reviews
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Strikethrough Rate:~~$120~~Discounted rate:$114USD/night
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Below are additional hotels in the area that do not match your exact search criteria.

Comfort Inn & Suites Santee I-95
221 Britain Street,
Santee, SC, 29142, US
0.92 mi from Santee, SC
3.92 stars rating. Good. 1702 reviews3.92 stars rating. Good. 1702 reviews
BOOK NOW AND SAVE 19%
Strikethrough Rate:~~$165~~Discounted rate:$134USD/night
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Econo Lodge
9112 Old Number 6 Hwy,
Santee, SC, 29142, US
1.32 mi from Santee, SC
3 stars rating. Fair. 164 reviews3 stars rating. Fair. 164 reviews
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Strikethrough Rate:~~$95~~Discounted rate:$91USD/night
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Econo Lodge
5971 West Jim Bilton Blvd.,
Saint George, SC, 29477, US
20.44 mi from Santee, SC
3.05 stars rating. 351 reviews3.05 stars rating. 351 reviews
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Strikethrough Rate:~~$69~~Discounted rate:$66USD/night
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Sleep Inn
3689 St. Matthews Rd,
Orangeburg, SC, 29118, US
20.36 mi from Santee, SC
3.89 stars rating. Good. 1270 reviews3.89 stars rating. Good. 1270 reviews
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Strikethrough Rate:~~$115~~Discounted rate:$98USD/night
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Suburban Studios
3671 Saint Matthews Road, Building B,
Orangeburg, SC, 29118, US
20.43 mi from Santee, SC
4.18 stars rating. Very Good. 78 reviews4.18 stars rating. Very Good. 78 reviews
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Strikethrough Rate:~~$91~~Discounted rate:$86USD/night
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Comfort Inn & Suites
746 Citadel Road,
Orangeburg, SC, 29118, US
20.26 mi from Santee, SC
3.92 stars rating. Good. 1588 reviews3.92 stars rating. Good. 1588 reviews
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Strikethrough Rate:~~$189~~Discounted rate:$180USD/night
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Palmetto Inn
6137 Alex Harvin Hwy,
Manning, SC, 29102, US
16.71 mi from Santee, SC
No Reviews YetNo Reviews Yet
Coming soonStart booking Aug 02, 2025
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Good to know

Number of hotels

3 of 10 hotels in Santee

Highest Price

$180

Lowest Price

$66

Avg. rating

3.2 (7216 reviews)