Experience Route 66 through Missouri
Travel the heart of the Mother Road as Route 66 winds across Missouri, connecting lively cities, small-town gems, and some of the most cherished stops on the entire route.
Beginning in St. Louis and stretching through Cuba, Lebanon, Springfield, and into the Ozarks, this part of the highway blends nostalgic icons with natural beauty and historic charm. Whether you're exploring for a day or road-tripping the full route, Missouri offers memorable stops at every turn. Choice Hotels provide convenient and relaxing places to stay along Route 66 in Missouri, giving you a place to recharge between adventures.
Top Route 66 stops in Missouri
Chain of Rocks Bridge (St. Louis) — A historic crossing with a unique 22-degree bend overlooking the Mississippi River.
Meramec Caverns (Stanton) — One of Route 66’s most famous show caves, known for dramatic underground formations.
Cuba’s Route 66 Mural City — More than a dozen large outdoor murals celebrating local history and Mother Road culture.
Lebanon Route 66 Museum — Exhibits featuring vintage cars, classic road signs, and midcentury memorabilia.
Springfield — “Birthplace of Route 66” — Home to historic markers, museums, and a vibrant Route 66-themed district.
Scenic and historic highlights
Devil’s Elbow — A scenic Ozark Mountain curve once known as one of the trickiest bends on the route.
Route 66 Rocker Park (Fanning) — Famous for the massive “World’s Largest Rocking Chair.”
Historic motels, neon signs, and classic diners — Throughout the St. Louis and Springfield corridors.
Choice Hotels along Route 66 in Missouri
From St. Louis to Springfield and everywhere in between, Choice Hotels offers convenient locations, modern amenities, and reliable stays near Missouri’s top Route 66 attractions.