9 hotels near Santee, SC, US

9 hotels near Santee, SC, US

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    • Quality Inn & Suites Santee I-95

      8929 Old Number Six Highway,
      Santee, SC, 29142, US
      1.08 mi from Santee, SC, US
      2.42 stars rating. Fair. 305 reviews

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      Strikethrough Rate:$69Discounted rate:$65USD/night
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    • Comfort Inn & Suites Santee I-95

      221 Britain Street,
      Santee, SC, 29142, US
      0.92 mi from Santee, SC, US
      3.94 stars rating. Good. 1793 reviews

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      Strikethrough Rate:$144Discounted rate:$130USD/night
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    • Econo Lodge Santee

      9112 Old Number 6 Hwy,
      Santee, SC, 29142, US
      1.32 mi from Santee, SC, US
      2.98 stars rating. Fair. 174 reviews

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      Strikethrough Rate:$74Discounted rate:$69USD/night
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    • Quality Inn & Suites Orangeburg

      3671 Saint Matthews Road, Building A,
      Orangeburg, SC, 29118, US
      20.37 mi from Santee, SC, US
      3.48 stars rating. Good. 1860 reviews

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      Strikethrough Rate:$80Discounted rate:$76USD/night
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    • Suburban Studios Orangeburg

      3671 Saint Matthews Road, Building B,
      Orangeburg, SC, 29118, US
      20.43 mi from Santee, SC, US
      4.2 stars rating. Excellent. 169 reviews

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      Strikethrough Rate:$89Discounted rate:$85USD/night
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    • Quality Inn Manning I-95

      3031 Paxville Highway,
      Manning, SC, 29102, US
      21.09 mi from Santee, SC, US
      3.9 stars rating. Good. 165 reviews

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      Strikethrough Rate:$90Discounted rate:$84USD/night
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    • Econo Lodge St. George

      5971 West Jim Bilton Blvd.,
      Saint George, SC, 29477, US
      20.44 mi from Santee, SC, US
      3.07 stars rating. Fair. 392 reviews

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      Strikethrough Rate:$69Discounted rate:$64USD/night
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    • Sleep Inn Orangeburg

      3689 St. Matthews Rd,
      Orangeburg, SC, 29118, US
      20.36 mi from Santee, SC, US
      3.87 stars rating. Good. 1363 reviews

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      Strikethrough Rate:$129Discounted rate:$116USD/night
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    • Comfort Inn & Suites Orangeburg

      746 Citadel Road,
      Orangeburg, SC, 29118, US
      20.26 mi from Santee, SC, US
      3.93 stars rating. Good. 1743 reviews

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      Strikethrough Rate:$159Discounted rate:$143USD/night
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    Santee Travel Tips

    Santee Hotels

    Discover this small South Carolina town—popular with golfers and nature lovers— when you check out our Santee travel guide.

    Santee Hotels

    Book with Choice Hotels in Santee, SC for an adventure-filled trip any time of year. Known for its golf and fishing, the resort town of Santee, SC is a prime destination for outdoor fun. But when you're ready to head indoors, there is plenty to keep you entertained. Spend the day enjoying the town's natural beauty with a wide range of activities. Then, feast on flavorful Southern cuisine and take your pick of live music venues. After you arrive to your hotel in Santee, check out the most popular attractions, including: Wyboo Golf Club, Palmetto Trail, Clarke's Restaurant and Pub, Santee General Store, Santee Cooper Lakes System and LT's Restaurant and Nite Life.

    Golfers should waste no time getting to the links at one of Santee's 11 spectacular courses, including the prestigious Wyboo Golf Club. Frequented by golfers of varying ages and experience, this public golf course features an interesting mix of lateral water, sloping greens and well-placed bunkers. All types of outdoor enthusiasts will enjoy the adventures on Palmetto Trail. Stretching 13 miles in Santee alone, the trail, with its picturesque natural beauty, is the perfect place for biking, hiking or camping. After working up an appetite, head to Clarke's Restaurant and Pub, where your mouth will water at the sight and aroma of authentic Southern cooking. Enjoy fine food and spirits in this cozy fireside atmosphere. Top off your meal with a hand-dipped ice cream cone at the nostalgic Santee General Store, where you can also shop for souvenirs and other items. A town landmark, this charmingly quaint store stocks a good selection of jellies, preserves, ciders, dressings and much more.

    Visitors who enjoy fishing can have a great time year round in the Santee Cooper Lakes System, which consists of the vast Lake Moultrie and the cypress-dotted Lake Marion. These lakes are filled with all sorts of exciting catches—from channel catfish to striped bass to shellcracker—and currently hold several state records. When the sun goes down, dance the night away after a delectable dinner at LT's Restaurant and Nite Life. A popular spot with a casual atmosphere, LT's lounge, which offers live entertainment, is open Thursday, Friday and Saturday while the restaurant is open nightly. 

    Before your visit, be sure to reserve a room with Choice Hotels in Santee, SC, where you will be near everything the town has to offer.

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    Number of hotels

    9 hotels in Santee

    Highest Price

    $143

    Lowest Price

    $64

    Avg. rating

    3.5 (7964 reviews)