Book Top Rated Hotels in Defiance, MO

Comfort Inn & Suites Chesterfield - St. Louis
18375 Chesterfield Arpt. Rd.,
Chesterfield, MO, 63005, US
7.35 mi from Defiance, MO, US
3.91 stars rating. Good. 2483 reviews
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Strikethrough Rate:~~$103~~Discounted rate:$84USD/night
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Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive,
O Fallon, MO, 63368, US
6.99 mi from Defiance, MO, US
4.23 stars rating. Excellent. 1258 reviews
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Strikethrough Rate:~~$120~~Discounted rate:$103USD/night
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Comfort Inn & Suites St. Louis-O'Fallon
8170 Veterans Memorial Pkwy,
O Fallon, MO, 63366, US
12.77 mi from Defiance, MO, US
3.68 stars rating. Good. 1907 reviews
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Strikethrough Rate:~~$110~~Discounted rate:$107USD/night
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Quality Inn Pacific near Six Flags St. Louis
1400 West Osage St.,
Pacific, MO, 63069, US
10.32 mi from Defiance, MO, US
4 stars rating. Very Good. 657 reviews
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Strikethrough Rate:~~$94~~Discounted rate:$85USD/night
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Comfort Inn Near Six Flags St. Louis
1320 Thornton St.,
Pacific, MO, 63069, US
10.19 mi from Defiance, MO, US
4.06 stars rating. Very Good. 1766 reviews
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Strikethrough Rate:~~$104~~Discounted rate:$99USD/night
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Quality Inn Foristell
12 Highway W,
Foristell, MO, 63348, US
15.91 mi from Defiance, MO, US
4.21 stars rating. Excellent. 926 reviews
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Strikethrough Rate:~~$99~~Discounted rate:$80USD/night
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AWARD WINNER
Comfort Suites St. Louis - Sunset Hills
3654 S. Lindbergh Blvd.,
Saint Louis, MO, 63127, US
20.86 mi from Defiance, MO, US
4.72 stars rating. Exceptional. 1954 reviews
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Strikethrough Rate:~~$124~~Discounted rate:$118USD/night
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Country Inn & Suites by Radisson, St. Peters, MO
3877 Veterans Memorial Pkwy,
Saint Peters, MO, 63376, US
16.01 mi from Defiance, MO, US
4.07 stars rating. Very Good. 225 reviews
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Strikethrough Rate:~~$144~~Discounted rate:$137USD/night
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Comfort Inn & Suites Hazelwood - St. Louis
7133 Douglas Palmer Place,
Hazelwood, MO, 63042, US
24.94 mi from Defiance, MO, US
4.11 stars rating. Very Good. 1989 reviews
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Strikethrough Rate:~~$112~~Discounted rate:$101USD/night
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Comfort Suites St Charles-St Louis
1400 S. Fifth Street,
Saint Charles, MO, 63301, US
18.1 mi from Defiance, MO, US
4.02 stars rating. Very Good. 2079 reviews
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Strikethrough Rate:~~$129~~Discounted rate:$123USD/night
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Comfort Inn St. Louis Airport
11225 Lone Eagle Dr., Building A,
Bridgeton, MO, 63044, US
21.82 mi from Defiance, MO, US
4.05 stars rating. Very Good. 183 reviews
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Strikethrough Rate:~~$132~~Discounted rate:$113USD/night
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AWARD WINNER
Country Inn & Suites by Radisson, St. Charles Historic District
1190 South Main Street,
Saint Charles, MO, 63301, US
18.51 mi from Defiance, MO, US
4.65 stars rating. Exceptional. 649 reviews
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Strikethrough Rate:~~$229~~Discounted rate:$218USD/night
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Sleep Inn Saint Charles North
150 Fountain Lakes Blvd.,
Saint Charles, MO, 63301, US
19.34 mi from Defiance, MO, US
3.09 stars rating. Fair. 1040 reviews
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Strikethrough Rate:~~$95~~Discounted rate:$90USD/night
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MainStay Suites St. Louis Airport
11225 Lone Eagle Dr., Building B,
Bridgeton, MO, 63044, US
21.82 mi from Defiance, MO, US
3.91 stars rating. Good. 240 reviews
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Strikethrough Rate:~~$127~~Discounted rate:$109USD/night
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Quality Inn Florissant-St. Louis
55 Dunn Road,
Florissant, MO, 63031, US
25.85 mi from Defiance, MO, US
3.41 stars rating. Good. 1467 reviews
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Strikethrough Rate:~~$80~~Discounted rate:$76USD/night
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Quality Inn Saint Louis Airport
10232 Natural Bridge Rd.,
Saint Louis, MO, 63134, US
23.79 mi from Defiance, MO, US
3.27 stars rating. Good. 3055 reviews
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Strikethrough Rate:~~$87~~Discounted rate:$83USD/night
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Hollywood Casino St Louis
777 Casino Center Drive,
Maryland Heights, MO, 63043, US
18.05 mi from Defiance, MO, US
No Reviews Yet
$365USD/night
Fees included
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MainStay Suites St. Louis - Galleria
8011 Galleria Pkwy,
St. Louis, MO, 63117, US
23.47 mi from Defiance, MO, US
3.2 stars rating. Good. 193 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$129~~Discounted rate:$123USD/night
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River City Casino & Hotel
777 River City Casino Boulevard,
Saint Louis, MO, 63125, US
28.67 mi from Defiance, MO, US
No Reviews Yet
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Strikethrough Rate:~~$245~~Discounted rate:$211USD/night
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Comfort Inn St. Louis - Westport Event Center
12031 Lackland Rd.,
Saint Louis, MO, 63146, US
18.61 mi from Defiance, MO, US
3.55 stars rating. Good. 3113 reviews
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Good to know

Top-Rated hotels

20 hotels in Defiance

Highest Price

$365

Lowest Price

$76

Avg. rating

19 Top Rated hotels near Defiance, MO, US

Comfort Inn & Suites Chesterfield - St. Louis

Sleep Inn & Suites O'Fallon MO - Technology Drive

Comfort Inn & Suites St. Louis-O'Fallon

Quality Inn Pacific near Six Flags St. Louis

Comfort Inn Near Six Flags St. Louis

Quality Inn Foristell

Comfort Suites St. Louis - Sunset Hills

Country Inn & Suites by Radisson, St. Peters, MO

Comfort Inn & Suites Hazelwood - St. Louis

Comfort Suites St Charles-St Louis

Comfort Inn St. Louis Airport

Country Inn & Suites by Radisson, St. Charles Historic District

Sleep Inn Saint Charles North

MainStay Suites St. Louis Airport

Quality Inn Florissant-St. Louis

Quality Inn Saint Louis Airport

Hollywood Casino St Louis

MainStay Suites St. Louis - Galleria

River City Casino & Hotel

Change your dates to book properties below.

Comfort Inn St. Louis - Westport Event Center

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Good to know

20 hotels in Defiance

$365

$76

3.5 (25184 reviews)