Book Boutique Hotels in Odessa, TX | Choice Hotels

Comfort Inn & Suites, Odessa I-20
801 South JBS Parkway,
Odessa, TX, 79761, US
3.04 mi from Odessa, TX, USA
3.79 stars rating. Good. 662 reviews3.79 stars rating. Good. 662 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$90~~Discounted rate:$81USD/night
Member Rate
See Availability
MainStay Suites Odessa I-20
1801 S. Highway 385,
Odessa, TX, 79766, US
1.55 mi from Odessa, TX, USA
4.43 stars rating. Excellent. 213 reviews4.43 stars rating. Excellent. 213 reviews
BOOK NOW AND SAVE 3%
Strikethrough Rate:~~$79~~Discounted rate:$77USD/night
Member Rate
See Availability
Comfort Suites Odessa near University
4801 East 50th Street,
Odessa, TX, 79762, US
4.16 mi from Odessa, TX, USA
3.88 stars rating. Good. 676 reviews3.88 stars rating. Good. 676 reviews
BOOK NOW AND SAVE 15%
Strikethrough Rate:~~$97~~Discounted rate:$83USD/night
Member Rate
See Availability
Sleep Inn & Suites Odessa near University
3101 East Business 20,
Odessa, TX, 79761, US
3.48 mi from Odessa, TX, USA
3.96 stars rating. Good. 364 reviews3.96 stars rating. Good. 364 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$85~~Discounted rate:$77USD/night
Member Rate
See Availability
AWARD WINNER
Sleep Inn & Suites Midland West
5612 Deauville Blvd,
Midland, TX, 79706, US
15.98 mi from Odessa, TX, USA
4.41 stars rating. Excellent. 705 reviews4.41 stars rating. Excellent. 705 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$109~~Discounted rate:$98USD/night
Member Rate
See Availability
Comfort Suites Midland West
5606 Westridge Blvd,
Midland, TX, 79706, US
16.13 mi from Odessa, TX, USA
4.26 stars rating. Excellent. 401 reviews4.26 stars rating. Excellent. 401 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$104~~Discounted rate:$94USD/night
Member Rate
See Availability
AWARD WINNER
Suburban Studios Midland I-20
3001 Antelope Trail,
Midland, TX, 79706, US
15.02 mi from Odessa, TX, USA
4.41 stars rating. Excellent. 193 reviews4.41 stars rating. Excellent. 193 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$85~~Discounted rate:$81USD/night
Member Rate
See Availability
Comfort Inn Midland South I-20
910 West I-20,
Midland, TX, 79701, US
19.1 mi from Odessa, TX, USA
3.69 stars rating. Good. 594 reviews3.69 stars rating. Good. 594 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$105~~Discounted rate:$95USD/night
Member Rate
See Availability
Quality Suites Midland North Loop 250
4706 North Garfield Street,
Midland, TX, 79705, US
20.1 mi from Odessa, TX, USA
4 stars rating. Very Good. 642 reviews4 stars rating. Very Good. 642 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$109~~Discounted rate:$98USD/night
Member Rate
See Availability
MainStay Suites Midland
2500 South Lamesa Road,
Midland, TX, 79701, US
20.3 mi from Odessa, TX, USA
3.7 stars rating. Good. 189 reviews3.7 stars rating. Good. 189 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$99~~Discounted rate:$94USD/night
Member Rate
See Availability
Rodeway Inn Midland South
1000 S Midkiff Rd,
Midland, TX, 79701-7132, US
17.56 mi from Odessa, TX, USA
1.35 stars rating. Fair. 17 reviews1.35 stars rating. Fair. 17 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$65~~Discounted rate:$59USD/night
Member Rate
See Availability

Change your dates to book properties below.

NEW TO CHOICE
Quality Inn
3071 E Business 20,
Odessa, TX, 79761, US
3.37 mi from Odessa, TX, USA
No Reviews YetNo Reviews Yet
Coming soonStart booking Feb 02, 2026
See Availability
Quality Inn Midland South
902 Interstate 20 West,
Midland, TX, 79701, US
19.21 mi from Odessa, TX, USA
3.89 stars rating. Good. 598 reviews3.89 stars rating. Good. 598 reviews
Sold outfor your selected dates
See Availability

Other Odessa searches

All Hotels in Odessa

Hotel Deals in Odessa

Extended Stay Hotels in Odessa

Pet Friendly Hotels in Odessa

Top Rated Hotels in Odessa

Good to know

Boutique hotels

13 hotels in Odessa

Highest Price

$98

Lowest Price

$59

Avg. rating

3.5 (5254 reviews)