Book Ascend Hotels in Santa Fe, TX

Quality Inn Texas City I-45
2320 FM 2004,
Texas City, TX, 77591, US
8.06 km from Santa Fe, TX, USA
3.51 stars rating. Good. 467 reviews3.51 stars rating. Good. 467 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$62~~Discounted rate:$58USD/night
Member Rate
See Availability
Comfort Inn & Suites Texas City I-45
10700 Emmett F. Lowry Expwy,
Texas City, TX, 77591, US
8.02 km from Santa Fe, TX, USA
2.09 stars rating. Fair. 34 reviews2.09 stars rating. Fair. 34 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$68~~Discounted rate:$63USD/night
Member Rate
See Availability
Comfort Suites near NASA - Clear Lake
16931 N. Texas Ave,
Webster, TX, 77598, US
18.44 km from Santa Fe, TX, USA
3.89 stars rating. Good. 1149 reviews3.89 stars rating. Good. 1149 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$85~~Discounted rate:$77USD/night
Member Rate
See Availability
Quality Inn & Suites Seabrook- NASA- Kemah
2720 Nasa Parkway,
Seabrook, TX, 77586, US
21.3 km from Santa Fe, TX, USA
4.39 stars rating. Excellent. 1214 reviews4.39 stars rating. Excellent. 1214 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$88~~Discounted rate:$79USD/night
Member Rate
See Availability
Seabreeze Hotel, an Ascend Collection Hotel
2311 Avenue P 1 2,
Galveston, TX, 77550, US
32.22 km from Santa Fe, TX, USA
4.48 stars rating. Excellent. 33 reviews4.48 stars rating. Excellent. 33 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$80~~Discounted rate:$72USD/night
Member Rate
See Availability
Sleep Inn & Suites Galveston Island
6628 Broadway Street,
Galveston, TX, 77554, US
27.01 km from Santa Fe, TX, USA
2.95 stars rating. Fair. 849 reviews2.95 stars rating. Fair. 849 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$59~~Discounted rate:$55USD/night
Member Rate
See Availability
Quality Inn & Suites Galveston - Beachfront
5924 Seawall Blvd.,
Galveston, TX, 77551, US
29.92 km from Santa Fe, TX, USA
4.04 stars rating. Very Good. 3167 reviews4.04 stars rating. Very Good. 3167 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$70~~Discounted rate:$63USD/night
Member Rate
See Availability
Comfort Suites Seabrook - Kemah
5755 Bayport Blvd,
Seabrook, TX, 77586, US
24.85 km from Santa Fe, TX, USA
3.26 stars rating. Good. 264 reviews3.26 stars rating. Good. 264 reviews
BOOK NOW AND SAVE 19%
Strikethrough Rate:~~$75~~Discounted rate:$61USD/night
Member Rate
See Availability
MainStay Suites Houston NASA/Clear Lake
1050 Bay Area Blvd,
Houston, TX, 77058, US
19.73 km from Santa Fe, TX, USA
3.41 stars rating. Good. 97 reviews3.41 stars rating. Good. 97 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$89~~Discounted rate:$83USD/night
Member Rate
See Availability
Econo Lodge Galveston Seawall
3008 Seawall Blvd,
Galveston, TX, 77550-7677, US
31.85 km from Santa Fe, TX, USA
2.76 stars rating. Fair. 119 reviews2.76 stars rating. Fair. 119 reviews
BOOK NOW AND SAVE 5%
Strikethrough Rate:~~$50~~Discounted rate:$48USD/night
Member Rate
See Availability
Rodeway Inn South Houston
2042 Houston Blvd.,
South Houston, TX, 77587, US
32.91 km from Santa Fe, TX, USA
2.97 stars rating. Fair. 118 reviews2.97 stars rating. Fair. 118 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$57~~Discounted rate:$53USD/night
Member Rate
See Availability
Quality Suites Houston Hobby Airport
7775 Airport Blvd,
Houston, TX, 77061, US
35.39 km from Santa Fe, TX, USA
3.95 stars rating. Good. 219 reviews3.95 stars rating. Good. 219 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$68~~Discounted rate:$61USD/night
Member Rate
See Availability
Comfort Suites
3606 89th Street,
Galveston, TX, 77554, US
28.22 km from Santa Fe, TX, USA
3.47 stars rating. Good. 1677 reviews3.47 stars rating. Good. 1677 reviews
BOOK NOW AND SAVE 12%
Strikethrough Rate:~~$98~~Discounted rate:$86USD/night
Member Rate
See Availability
Quality Inn Houston East I-10
828 Mercury Drive,
Houston, TX, 77013, US
46.14 km from Santa Fe, TX, USA
2.97 stars rating. Fair. 450 reviews2.97 stars rating. Fair. 450 reviews
BOOK NOW AND SAVE 14%
Strikethrough Rate:~~$65~~Discounted rate:$56USD/night
Member Rate
See Availability
Comfort Inn & Suites
2818 Avenue R 1 2,
Galveston, TX, 77550, US
31.92 km from Santa Fe, TX, USA
3.24 stars rating. Good. 226 reviews3.24 stars rating. Good. 226 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$73~~Discounted rate:$68USD/night
Member Rate
See Availability
Quality Inn & Suites NRG Park - Medical Center
2364 South Loop West,
Houston, TX, 77054, US
44.82 km from Santa Fe, TX, USA
3.02 stars rating. 1464 reviews3.02 stars rating. 1464 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$70~~Discounted rate:$63USD/night
Member Rate
See Availability
MainStay Suites Texas Medical Center/Reliant Park
3134 Old Spanish Trail,
Houston, TX, 77054, US
44.4 km from Santa Fe, TX, USA
3.97 stars rating. Good. 2343 reviews3.97 stars rating. Good. 2343 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$79~~Discounted rate:$73USD/night
Member Rate
See Availability
Comfort Suites
15813 2nd Street,
Channelview, TX, 77530, US
44.61 km from Santa Fe, TX, USA
3.33 stars rating. Good. 295 reviews3.33 stars rating. Good. 295 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$67~~Discounted rate:$62USD/night
Member Rate
See Availability
Econo Lodge Inn & Suites East Houston I-10
1016 Maxey Road,
Houston, TX, 77015, US
45 km from Santa Fe, TX, USA
4.05 stars rating. Very Good. 386 reviews4.05 stars rating. Very Good. 386 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$67~~Discounted rate:$60USD/night
Member Rate
See Availability
Comfort Suites La Porte - Baytown
902 South 8th Street,
La Porte, TX, 77571, US
31.56 km from Santa Fe, TX, USA
4.21 stars rating. Excellent. 680 reviews4.21 stars rating. Excellent. 680 reviews
BOOK NOW AND SAVE 19%
Strikethrough Rate:~~$110~~Discounted rate:$89USD/night
Member Rate
See Availability
Rodeway Inn & Suites Houston near Medical Center
6712 Morningside Drive,
Houston, TX, 77030, US
47.17 km from Santa Fe, TX, USA
2.54 stars rating. Fair. 397 reviews2.54 stars rating. Fair. 397 reviews
BOOK NOW AND SAVE 16%
Strikethrough Rate:~~$62~~Discounted rate:$52USD/night
Member Rate
See Availability
Sleep Inn & Suites Pearland - Houston South
1908 Country Place Parkway,
Pearland, TX, 77584, US
34.82 km from Santa Fe, TX, USA
3.97 stars rating. Good. 655 reviews3.97 stars rating. Good. 655 reviews
BOOK NOW AND SAVE 10%
Strikethrough Rate:~~$92~~Discounted rate:$83USD/night
Member Rate
See Availability
Econo Lodge Inn & Suites
16007 East Fwy,
Channelview, TX, 77530, US
44.72 km from Santa Fe, TX, USA
3.44 stars rating. Good. 16 reviews3.44 stars rating. Good. 16 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$58~~Discounted rate:$54USD/night
Member Rate
See Availability
Comfort Suites Deer Park Pasadena
1501 Center St.,
Deer Park, TX, 77536, US
35.53 km from Santa Fe, TX, USA
3.96 stars rating. Good. 574 reviews3.96 stars rating. Good. 574 reviews
BOOK NOW AND SAVE 21%
Strikethrough Rate:~~$113~~Discounted rate:$89USD/night
Member Rate
See Availability
Quality Inn Pasadena - Houston East
114 S. Richey St.,
Pasadena, TX, 77506, US
38.61 km from Santa Fe, TX, USA
3.82 stars rating. Good. 313 reviews3.82 stars rating. Good. 313 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$89~~Discounted rate:$83USD/night
Member Rate
See Availability
Comfort Suites Houston near Medical Center- NRG Stadium
1055 McNee Road, East of Main Street,
Houston, TX, 77054, US
45.84 km from Santa Fe, TX, USA
4.32 stars rating. Excellent. 1774 reviews4.32 stars rating. Excellent. 1774 reviews
BOOK NOW AND SAVE 7%
Strikethrough Rate:~~$124~~Discounted rate:$115USD/night
Member Rate
See Availability

Change your dates to book properties below.

Clarion Pointe Galveston - Beachfront
5914 Seawall Blvd,
Galveston, TX, 77551, US
29.96 km from Santa Fe, TX, USA
No Reviews YetNo Reviews Yet
Coming soonStart booking 01 Dec 2025
See Availability

Good to know

Number of hotels

27 hotels in Santa Fe

Highest Price

$115

Lowest Price

$48

Avg. rating

26 hotels near Santa Fe, TX, USA

Quality Inn Texas City I-45

Comfort Inn & Suites Texas City I-45

Comfort Suites near NASA - Clear Lake

Quality Inn & Suites Seabrook- NASA- Kemah

Seabreeze Hotel, an Ascend Collection Hotel

Sleep Inn & Suites Galveston Island

Quality Inn & Suites Galveston - Beachfront

Comfort Suites Seabrook - Kemah

MainStay Suites Houston NASA/Clear Lake

Econo Lodge Galveston Seawall

Rodeway Inn South Houston

Quality Suites Houston Hobby Airport

Comfort Suites

Quality Inn Houston East I-10

Comfort Inn & Suites

Quality Inn & Suites NRG Park - Medical Center

MainStay Suites Texas Medical Center/Reliant Park

Comfort Suites

Econo Lodge Inn & Suites East Houston I-10

Comfort Suites La Porte - Baytown

Rodeway Inn & Suites Houston near Medical Center

Sleep Inn & Suites Pearland - Houston South

Econo Lodge Inn & Suites

Comfort Suites Deer Park Pasadena

Quality Inn Pasadena - Houston East

Comfort Suites Houston near Medical Center- NRG Stadium

Change your dates to book properties below.

Clarion Pointe Galveston - Beachfront

Other Santa Fe searches

Good to know

27 hotels in Santa Fe

$115

$48

3.4 (18980 reviews)